Biochemical correlates of illness and recovery in Reye's syndrome

Trauner, Doris A.; Sweetman, Lawrence; Holm, Janette; Kulovich, Stanko; Nyhan, William L.

doi:10.1002/ana.410020310

Cited by 70 publications

(7 citation statements)

References 12 publications

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“…In our initial search, we found a total of 10,008 articles. Removal of duplicates and use of the selection criteria reduced the number of articles to 15 12 – 26 (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

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Tranexamic acid in non-traumatic intracranial bleeding: a systematic review and meta-analysis

Bouillon‐Minois

Croizier

Baker

et al. 2021

Sci Rep

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Non-traumatic intracranial bleeding (NTIB), comprising subarachnoid hemorrhage (SAH) and intra-cranial bleeding (ICH) is a significant public health concern. Tranexamic acid (TXA) is a promising treatment with benefits yet to be fully demonstrated. We conducted a systematic review and meta-analysis on the impact of TXA on mortality in NTIB. We searched the PubMed, Cochrane Library, Google Scholar and ScienceDirect databases for studies reporting mortality data following the use of TXA in NTIB for comparisons with a control group. We computed random-effect meta-analysis on estimates of risk and sensitivity analyses. We computed meta-regression to examine the putative effects of the severity of NTIB, sociodemographic data (age, sex), and publication date. Among potentially 10,008 articles, we included 15 studies representing a total of 4883 patients: 2455 receiving TXA and 2428 controls; 1110 died (23%) during the follow-up. The meta-analysis demonstrated a potential of 22% decrease in mortality for patients treated by TXA (RR = 0.78, 95%CI 0.58–0.98, p = 0.002). Meta-regression did not demonstrate any influence of the severity of NTIB, age, sex, length of treatment or date of publication. Sensitivity analyses confirmed benefits of TXA on mortality. TXA appears to be a therapeutic option to reduce non-traumatic intracranial bleeding mortality, particularly in patients with SAH.

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“…In our initial search, we found a total of 10,008 articles. Removal of duplicates and use of the selection criteria reduced the number of articles to 15 12 – 26 (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…All participants were adults > 18 years old with a NTIB. Age was reported in thirteen studies, either as mean 14 , 16 , 20 – 23 , 25 , 26 or age class 12 , 13 , 15 , 18 , 24 . Most patients (> 90%) were under 70 years old.…”

Section: Resultsmentioning

confidence: 99%

Tranexamic acid in non-traumatic intracranial bleeding: a systematic review and meta-analysis

Bouillon‐Minois

Croizier

Baker

et al. 2021

Sci Rep

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show abstract

“…An excess of free fatty acids has been claimed [ a ] . Recently a mechanism similar to the third lesion, Reye' s syndrome [5,15,141,171], has been proposed (…”

Section: Severe Nonalcoholic Steatosismentioning

confidence: 99%

Pathology of Alcoholic Liver Diseases

Pópper¹,

Thung²,

Gerber³

1981

Semin Liver Dis

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“…The strong association between ingestion of salicylate during the antecedent viral illness and the onset of RS, and the accumulation of fatty acids in RS (15)(16)(17)(18), prompted us to examine the effect of salicylic acid on fatty acid metabolism. The salicylate concentrations used herein are similar to the serum levels observed in RS patients (1 1-14).…”

Section: Discussionmentioning

confidence: 99%

“…Because of the high levels of salicylic acid in the plasma of many RS patients, the role of aspirin in the RS disease process has received particular attention (1 1 -14). Mitochondrial defects and an accumulation of free fatty acids (15)(16)(17)(18) and dicarboxylic acids (19,20) in RS suggest an abnormality in fatty acid metabolism. Herein we report the effect of salicylic acid on mitochondrial-peroxisomal fatty acid catabolism.…”

mentioning

confidence: 99%