Biochemical Differences (O-Acetyl and Glycolyl Groups) in Erythrocyte Surface Sialic Acids of Trypanotolerant N'dama and Trypanosusceptible Zebu Cattle

Shugaba, A.; Umar, I.A.; Omage, J. J.; Ibrahim, N. D. G.; Andrews, J. J. N.; Ukoha, A. I.; Saror, D.I.; Esievo, K. A. N.

doi:10.1016/s0021-9975(08)80273-3

Cited by 17 publications

(8 citation statements)

References 13 publications

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“…In T. evansi, an isolated sialidase was found to desialate ghost RBC in the following order of efficiency: mouse, rat, camel, goat, and dog (115). This host specificity could be linked to different sialic acid compositions between hosts, as was shown to be the case between NЈDama and zebu cattle (143). Indeed, sialic acid was shown to contain less O-acetyl than glycolyl groups in zebu cattle, while the inverse situation occurred in trypanotolerant NЈDama cattle.…”

Section: New Candidatesmentioning

confidence: 88%

Host-Parasite Interactions in Trypanosomiasis: on the Way to an Antidisease Strategy

2009

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Section: New Candidatesmentioning

confidence: 88%

Host-Parasite Interactions in Trypanosomiasis: on the Way to an Antidisease Strategy

2009

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“…While for the 7: cruzi enzyme only a-2,3-but not a-2,6-linked sialic acids are donors in the transfer reaction [550], the 7: brucei trans-sialidase can also transfer a-2,6-linked sialic acids from sialyllactose to other glycans, however at an eight times lower rate than from sialyl(a2-3)lactose [755]. This may be the reason why N'dama cattle exhibiting a high degree of 0-acetylation of erythrocyte sialic acids are more trypanotolerant than Zebu cattle, whose erythrocyte sialic acids are much less 0-acetylated [703]. This may be the reason why N'dama cattle exhibiting a high degree of 0-acetylation of erythrocyte sialic acids are more trypanotolerant than Zebu cattle, whose erythrocyte sialic acids are much less 0-acetylated [703].…”

Section: Trans-sialidasesmentioning

confidence: 99%

Chemistry, biochemistry and biology of sialic acids

Schauer

Kamerling

1997

New Comprehensive Biochemistry

168

228

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“…the O-acetylated derivatives are resistant to enzymic cleavage and for such sialic acid types, higher amounts of neuraminidase are required to cleave them from the erythrocytes of infected animals to cause anaemia. [10][11][12] Some indigenous Nigerian poultry species have been reported to harbour the velogenic strain of NDV and yet remain apparently healthy, with no obvious anaemia. 13,14 The indigenous Nigerian animal species are more resistant to infectious disease agents than their exotic counterparts, [15][16][17] a feature attributed to genetic resistance.…”

Section: Introductionmentioning

confidence: 99%

Comparative studies on erythrocyte sialic acid levels in apparently healthy indigenous Nigerian poultry species

Useh

Omeiza

Nok

et al. 2006

Cell Biochem. Funct.

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The erythrocyte surface sialic acid levels of 200 apparently healthy indigenous Nigerian poultry species (pigeons, guinea fowls, ducks and chickens, n = 50 for each species) presented for slaughter at a poultry abattoir in Zaria, Nigeria was determined. Other parameters determined were packed cell volume (PCV) and plasma total protein (TP) concentration. The mean erythrocyte surface sialic acid concentration of pigeons, guinea fowls, ducks and chickens were 7.88 +/- 2.51, 14.6 +/- 2.51, 17.6 +/- 2.51 and 14.2 +/- 2.51 mg mg(-1) respectively. There was a statistically significant difference between the mean erythrocyte surface sialic acid concentration of all the species of poultry sampled (P < 0.05). The high erythrocyte surface sialic acid concentration in the indigenous Nigerian poultry species could be responsible for their resistance to infectious diseases, whose aetiologic agents produce neuraminidases. The mean PCV of the pigeons, guinea fowls, ducks and chickens were 46.22 +/- 6.91, 38.24 +/- 6.91, 36.50 +/- 6.91 and 36.46 +/- 6.91% respectively. The difference between the mean PCV values of pigeons on the one hand and guinea fowls, ducks and chickens on the other was statistically significant (P < 0.05). A negative correlation (r = -0.36, P < 0.05) between mean erythrocyte surface sialic acid concentrations and PCV was observed, i.e. the birds with the highest mean PCV values had the lowest levels of erythrocyte surface sialic acid. There was no correlation between TP concentration and either erythrocyte surface sialic acid concentration or PCV values. It is suggested, based on this study, that erythrocyte sialic acid types in these species should be determined, as the results may be vital in selective breeding.

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Biochemical Differences (O-Acetyl and Glycolyl Groups) in Erythrocyte Surface Sialic Acids of Trypanotolerant N'dama and Trypanosusceptible Zebu Cattle

Cited by 17 publications

References 13 publications

Host-Parasite Interactions in Trypanosomiasis: on the Way to an Antidisease Strategy

Host-Parasite Interactions in Trypanosomiasis: on the Way to an Antidisease Strategy

Chemistry, biochemistry and biology of sialic acids

Comparative studies on erythrocyte sialic acid levels in apparently healthy indigenous Nigerian poultry species

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