Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits

The protective effects of beta-mangostin against sodium iodate-induced retinal ROS-mediated apoptosis through MEK/ERK and p53 signaling pathways

“…34,35 BM was reported to possess several bioactivities such as cytotoxicity towards selective cancer cell lines, and anti-microbial and anti-inflammatory activities. 24,36,37 Syam et al have reported that BM is a very potent anti-inflammatory agent and suppresses LPS-induced inflammatory responses in RAW 264.7 macrophages. 38 However, the NaIO 3 -induced apoptosis through ROS-mediated mitochondrial dysfunction of BM in ARPE-19 cells remains unknown.…”

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“…It is worth noting that alternative methods, including supercritical fluid extraction, ultrasound-assisted extraction, and microwaveassisted extraction, have also been explored for the extraction of alpha-mangostin. These methods offer advantages such as shorter extraction times, reduced solvent consumption, and enhanced extraction efficiency, but their application in large-scale production and commercial settings requires further investigation [28][29][30]. The availability and abundance of mangosteen trees and the extraction yield of alpha-mangostin can vary depending on factors such as geographical location, climate, and cultivation practices.…”

“…Strategies such as nanoformulations, liposomes, or prodrug approaches may be explored to improve its solubility, stability, and targeted delivery to infected cells or tissues. Moreover, the development of suitable dosage forms, including oral, topical, or intravenous formulations, would contribute to its clinical feasibility and efficacy [29,31].…”

Therapeutic Targeting of Regulated Signaling Pathways of Non-Small Cell Lung Carcinoma

“…32 Phytochemicals possess various health-promoting functions, including cancer fight. 33 These molecules are responsible for preventing diseases. Phytochemicals, as plant constituents with distinct bioactivities toward biochemistry and metabolism, are being extensively studied for their capability to provide health benefits.…”

“…Phytochemicals have antioxidant action, antimicrobial results, modulation and detoxification enzymes, immune system incentive, reduction of platelet aggregation, neuroprotective effects, and anticancer properties . Phytochemicals possess various health-promoting functions, including cancer fight . These molecules are responsible for preventing diseases.…”