Biochemical, kinetic, and structural characterization of a Bacillus tequilensis nitroreductase
Sara Russo,
Henriette J. Rozeboom,
Hein J. Wijma
et al.
Abstract:Nitroreductases (NRs) are NAD(P)H‐dependent flavoenzymes that reduce nitro aromatic compounds to their corresponding arylamines via the nitroso and hydroxylamine intermediates. Because of their broad substrate scope and versatility, NRs have found application in multiple fields such as biocatalysis, bioremediation, cell‐imaging and prodrug activation. However, only a limited number of members of the broad NR superfamily (> 24 000 sequences) have been experimentally characterized. Within this group of enzyme… Show more
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