Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase

Urade, Yoshihiro; Hayaishi, Osamu

doi:10.1016/s0167-4838(00)00161-8

Cited by 298 publications

(251 citation statements)

References 101 publications

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“…We do not know precisely how 2-AG crosses the water-filled cleft to reach CB 1 r-containing terminals, but its amphipathic nature and/or its association with extracellular lipid-binding proteins 69,70 are likely to be important. Another element that may facilitate the transynaptic movement of 2-AG relates to the molecular structure of the CB 1 r. CB 1 r belongs to a subgroup of about 60 G-protein-coupled receptors that contain a characteristic alkyl-binding domain that is implicated in the recognition of lipid ligands 71 .…”

Section: Neurosteroidmentioning

confidence: 99%

A neuroscientist's guide to lipidomics

2007

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| Nerve cells mould the lipid fabric of their membranes to ease vesicle fusion, regulate ion fluxes and create specialized microenvironments that contribute to cellular communication. The chemical diversity of membrane lipids controls protein traffic, facilitates recognition between cells and leads to the production of hundreds of molecules that carry information both within and across cells. With so many roles, it is no wonder that lipids make up half of the human brain in dry weight. The objective of neural lipidomics is to understand how these molecules work together; this difficult task will greatly benefit from technical advances that might enable the testing of emerging hypotheses.

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Section: Neurosteroidmentioning

confidence: 99%

A neuroscientist's guide to lipidomics

2007

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“…Furthermore, members of the epididymisspecific cluster display a striking region-specific expression within the epididymis. In addition, some lipocalins function exclusively as lipophylic ligand-binding proteins, but other lipocalins such as PGDS are multifunctional with both ligand binding and enzymatic activities (Urade and Hayaishi, 2000). Therefore, it is likely that from a common ancestral gene expressed in epididymis and other tissues the epididymal lipocalin cluster on mouse chromosome 2 has evolved by subfunctionalization to include new gene functions and expression patterns.…”

Section: The Epididymal Lipocalin Cluster Was Generated By Gene Duplimentioning

confidence: 99%

Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2

Suzuki

Lareyre

Sánchez

et al. 2004

Gene

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“…La PGD2 a une structure instable et subit rapidement une déshydra-tation pour former une grande variété de métabolites : 15-désoxy-PGD2, PGJ2 ou 15-désoxy-PGJ2. La L-PGDS est le premier membre de la superfamille des lipocalines, protéines sécrétées dans les espaces extracellulaires, qui lient et transportent les petites molécules lipophiles (rétinol, β-lactoglobuline, pigments biliaires ou hormones thyroïdiennes), à exercer une activité enzymatique [3]. [5,6].…”

Section: Les Prostaglandines : Synthèse Et Transduction Du Signalunclassified

“…La PGD2 est activement produite dans de nombreux organes mais c'est le prostanoïde le plus abondant dans le système nerveux central et les voies respiratoires des mammifères [3]. Des rôles essentiels dans la perception de la douleur, le sommeil, l'asthme allergique, l'inflammation et la reproduction (cette fonction sera développée dans le paragraphe suivant), ont été définis grâce à l'analyse des souris transgéniques L-PGDS ou des souris invalidées pour le gène L-PGDS et pour les gènes codant les récepteurs DP1 et CRTH2.…”

Section: Les Rôles De La Prostaglandine D2unclassified