Biochemical study on the effect of alpha-lipoic acid on lipid metabolism of rats fed high fat diet

Hussein, S.; Abdel‐Mageid, Afaf D.; Abu-ghazalla, Ahmed

doi:10.21608/bvmj.2015.32663

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…However, α-LA demonstrated a protective effect on renal tissue and the possibility of reversing the negative effect of ROS. Previous studies have also reported similar effects by α-LA in relation to lipid peroxidation (Abdelhalim et al 2020 ; Hussein et al 2012 ).…”

Section: Discussionsupporting

confidence: 64%

Antioxidant and Anti-inflammatory Effects of α-Lipoic Acid on Lipopolysaccharide-induced Oxidative Stress in Rat Kidney

Skibska

Kochan

Stańczak

et al. 2023

Arch. Immunol. Ther. Exp.

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Abstractα-Lipoic acid (α-LA) is a naturally occurring organosulfur component. Oxidative stress plays an essential role in the pathogenesis of various diseases, such as kidney and cardiovascular diseases, diabetes, neurodegenerative disorders, cancer and aging. Kidneys are especially vulnerable to oxidative stress and damage. The aim of the study was to evaluate the effect of α-LA on lipopolysaccharide (LPS)-induced oxidative stress parameters in rat kidneys. The experimental rats were divided into four groups: I—control (0.9% NaCl i.v.); II—α-LA (60 mg/kg b.w. i.v.); III—LPS (30 mg/kg b.w. i.v.); and IV—LPS + LA (30 mg/kg b.w. i.v. and 60 mg/kg b.w. i.v., respectively). In kidney homogenates the concentration of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide (H2O2), sulfhydryl groups (−SH), total protein, superoxide dismutase (SOD), total glutathione (tGSH), reduced glutathione (GSH), glutathione disulphide (GSSG) and the GSH/GSSG ratio were determined. In addition, the levels of tumour necrosis factor (TNF)-α, and interleukin (IL)-6 were measured to assess inflammation and was estimated kidney oedema. Studies have shown that α-LA administered after LPS administration attenuated kidney oedema and significantly decreased TBARS, H2O2, TNF-α, and IL-6 levels in rat kidneys. α-LA also resulted in increase −SH group, total protein, and SOD levels and ameliorated the GSH redox status when compared to the LPS group. The results suggest that α-LA plays an important role against LPS-induced oxidative stress in kidney tissue as well as downregulating the expression of pro-inflammatory cytokines. Graphical Abstract

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Section: Discussionsupporting

confidence: 64%

Antioxidant and Anti-inflammatory Effects of α-Lipoic Acid on Lipopolysaccharide-induced Oxidative Stress in Rat Kidney

Skibska

Kochan

Stańczak

et al. 2023

Arch. Immunol. Ther. Exp.

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“…They explained that ALA, which encourages cholesterol release into bile, depletes the intrahepatic pool of cholesterol and, as a result, increases cholesterol synthesis and metabolism. Furthermore, an ALA‐rich diet helps in reduction of hepatic lipid deposition both by stimulating β oxidation and by inhibiting fatty acid synthesis (Hussein et al, 2014). An earlier study by Zhang et al (2022) also supported this study analyses as it showed significant reduction in TC (22%) and LDL‐c (24%) among hypercholesterolemic patients after 8 weeks of consuming 600 mg/day SDG derived from flaxseeds (Torkan et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

Cookies enriched with anethole and secoisolariciresinol diglucoside from flaxseed and fennel seeds improve hypercholesterolemia, lipid profile, and liver functions: A pilot study

Noreen

Tufail

et al. 2023

Food Science & Nutrition

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Over millennia, flaxseeds and fennel seeds have captured greater attention owing to the broad spectrum of bioactive compounds and their respective therapeutic potential. They are well-known therapeutic plants, frequently used in home treatments for a variety of medical conditions. The novelty of this pilot study is to assess the beneficial health effects of secoisolariciresinol diglucoside (SDG) and anethole-based enriched cookies among hyperlipidemic patients. The result of sensory evaluation revealed that cookies with anethole and SDG (500 + 500 mg/day) were significantly acceptable in terms of color, texture, taste, and overall acceptability same as that of control. This study was performed among 34 patients with hyperlipidemia in a university-affiliated hospital, Lahore, Pakistan.

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“…29 Pemberian ALA dosis kisaran 50-1800 mg memberikan hasil yang bermakna dalam menurunkan kadar kolesterol total, trigliserida, dan LDL, serta meningkatkan HDL. 30 Dosis ALA yang dapat memberi-kan efek perbaikan lipid darah ialah 300 mg. 31 Efek penurunan berat badan dari ALA disebabkan oleh hambatan pada aktivitas AMP kinase (AMPK) pada hipotalamus. 10 AMPK merupakan pengatur utama pada metabolisme glukosa dan lipid pada sel dan akan diaktivasi ketika energi seluler habis.…”

Section: Hasil Penelitian Dan Bahasanunclassified

Pemberian alpha lipoic acid per oral dan latihan fisik intensitas sedang menurunkan berat badan dan lemak abodminal lebih banyak daripada latihan fisik intensitas sedang saja pada tikus Wistar jantan dengan obesitas

Chandra¹,

Pangkahila²,

Pangkahila³

2017

JBM

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This study was aimed to prove that oral administration of ALA and moderate physical exercise decrease body weight and abdominal fat more than moderate physical exercise only in obese male Wistar rats. This was a true experimental study with a post-test only control group design. Subjects were 30 Wistar rats (Rattus norvegicus), male, healthy, aged 4-5 months, and obese with minimum weight of 250 g, divided into 3 groups, as follows: 1) P0, the control group with no treatment; 2) P1, given moderate physical exercise (swimming for 20 minutes/day, for 4 weeks); 3) P2, given moderate physical exercise and ALA per oral 15 mg/day for 4 weeks. The results showed that the average body weight after 4 weeks of treatment of P0 group was 279.10±5.84 g; of P1 group was 257.90±10.31 g; and of P2 group was 213.90±8.92 g (P < 0.01). The mean weight of subcutaneous abdominal fat of P0 group was 0.96±0.45 g; of P1 group was 0.63±0.31 g; and of P2 group was 0.40±0.23 g (P < 0.01 ). Moreover, the mean weight of visceral abdominal fat of P0 group was 1.23±0.37 g; of P1 group was 0.83±0.24 g; and of P2 group was 0.39±0.25 g (P < 0,01). Conclusion: Oral administration of ALA and moderate physical exercise decrease body weight, subcutaneous abdominal fat, and visceral abdominal fat more than moderate physical exercise only in obese male Wistar rats.Keywords: alpha lipoic acid, obesity, body weight, abdominal fatAbstrak: Penelitian ini bertujuan untuk membuktikan bahwa pemberian ALA per oral yang dikombinasi dengan latihan fisik intensitas sedang menurunkan berat badan, lemak subkutan abdominal, dan lemak viseral abdominal lebih banyak daripada latihan fisik intensitas sedang saja pada tikus Wistar jantan dengan obesitas. Jenis penelitian ialah eksperimental murni dengan post-test only control group design. Subjek penelitian ialah 30 ekor tikus putih (Rattus norvegicus) jantan, galur Wistar, sehat, usia 4-5 bulan, dan obes dengan berat badan minimal 250 g yang terbagi menjadi tiga kelompok masing-masing berjumlah 10 ekor tikus, yaitu: P0 (kelompok kontrol), tidak mendapat perlakuan apapun; P1, kelompok perlakuan 1 yang diberikan latihan fisik intensitas sedang (renang durasi 20 menit/hari selama 4 minggu); dan P2, kelompok perlakuan 2 yang diberikan latihan fisik intensitas sedang serta ALA per oral dengan dosis 15mg/hari selama 4 minggu. Hasil penelitian menunjukkan bahwa rerata berat badan setelah 4 minggu perlakuan pada kelompok P0 ialah 279,10±5,84 gr; pada kelompok P1 257,90±10,31 gr; dan pada kelompok P2 213,90±8,92 gr (P < 0,01). Rerata berat lemak subkutan abdominal pada kelompok P0 ialah 0,96±0,45 gr; pada kelompok P1 0,63±0,31 gr; dan pada kelompok P2 0,40±0,23 gr (P < 0,01). Selain itu, rerata berat lemak viseral abdominal pada kelompok P0 ialah 1,23±0,37 gr; pada kelompok P1 0,83±0,24 gr; dan pada kelompok P2 0,39±0,25 gr (P < 0,01). Simpulan: Pemberian ALA per oral dengan latihan fisik intensitas sedang dapat menurunkan berat badan, lemak subkutan abdominal, dan lemak viseral abdominal lebih banyak daripada latihan fisik intensitas sedang saja pada tikus Wistar jantan dengan obesitasKata kunci: alpha lipoic acid, obesitas, berat badan, lemak abdominal

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Biochemical study on the effect of alpha-lipoic acid on lipid metabolism of rats fed high fat diet

Cited by 6 publications

References 13 publications

Antioxidant and Anti-inflammatory Effects of α-Lipoic Acid on Lipopolysaccharide-induced Oxidative Stress in Rat Kidney

Antioxidant and Anti-inflammatory Effects of α-Lipoic Acid on Lipopolysaccharide-induced Oxidative Stress in Rat Kidney

Cookies enriched with anethole and secoisolariciresinol diglucoside from flaxseed and fennel seeds improve hypercholesterolemia, lipid profile, and liver functions: A pilot study

Pemberian alpha lipoic acid per oral dan latihan fisik intensitas sedang menurunkan berat badan dan lemak abodminal lebih banyak daripada latihan fisik intensitas sedang saja pada tikus Wistar jantan dengan obesitas

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