Biochemical study on the effect of Toxoplasma gondii on Liver function in  Women

Muhsin, Salwa S.; Jafar, Eman Hussain; Jafar, Nasser Sadaq

doi:10.30539/ijvm.v37i2.1390

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Toxoplasmosis causes severe and progressive damage to the liver (18,19), remarkable proliferations of organisms such damage in the liver metabolism (20).We found that liver enzymes activities ALP, AST, and ALT were increased in T. gondii-infected women, Serum AST and ALT activities are excellent markers of hepatocellular injury and serum ALT activity is more specific than serum AST for assessing liver injury and this results consistent with previous studies conducted on experimental animals (21,22,23). The significantly elevated serum activities of liver enzymes also agreed with (24). Increased plasma AST and ALT activities reflects impairment of the liver, where this infection can cause round cell infiltration in the portal areas, cholestasis, swollen endothelial cells and focal necrosis of liver cells (25).When the liver is impaired the liver cells release…”

Section: Discussionsupporting

confidence: 59%

Effect of Toxoplasmosis on hematological, biochemical and immunological parameters in pregnant women in Tikrit city, Iraq

Mahmood¹

2023

Tikrit J. Pure Sci.

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The aim of the present study was to detect the effect of infection with Toxoplasma gondii on hematological, biochemical and immunological parameters in pregnant women. Blood samples, 101 in the total number, were subject to serological test (ELISA test) collected between first of September 2013 to the end of March 2014 from pregnant women: 76 seroposative toxoplasmosis and (25) seronegative toxoplasmosis (control group) divided into two groups according to their ages (16-26 years and 27-46 years). Hematological parameters in whole blood samples were examined. Liver enzyme activity such as Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline Phosphatase (ALP) also urea and creatinine concentration in serum were determined. Besides, the levels of interleukins (IL-6 and IL-10) were analyzed. In infected groups WBCs counts, ALT, AST, ALP activities, urea and creatinine concentration, IL-6 and IL-10 levels were increased significantly p≤0.05, while the Hb and PCV levels decreased significantly p≤0.05 when compared to control groups

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Section: Discussionsupporting

confidence: 59%

Effect of Toxoplasmosis on hematological, biochemical and immunological parameters in pregnant women in Tikrit city, Iraq

Mahmood¹

2023

Tikrit J. Pure Sci.

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“…The results of the fatigue tester revealed the number of periods required to break the samples. The fatigue S-N curve is drawn by plotting a curve that reflects the experimental data of fatigue tests [42,43]. Figs.…”

Section: Fatigue Propertiesmentioning

confidence: 99%

Fatigue and Tensile Characteristics for Composite Materials Used in Prosthetic Socket

Salim Khamees,

Khaleel

2023

IJP

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In this research, the use of natural materials like wool and cannabis as intermediate reinforcement for prosthetic limbs due to their comfort, affordability, and local availability was discussed. As part of this study on below-the-knee (BK) prosthetic sockets, two sets of samples were made using a vacuum method. These sets were made of natural fiber-reinforced polymer composites with lamination 80:20: group (Y) had 4 perlon, 1 wool 4 perlon, and group (G) had 4 perlon, 1 cannabis 4 perlon. The two groups were compared with a socket made of polypropylene. Tensile testing was used to determine the mechanical characteristics of the socket materials. The Y group has a yield stress of 17 MPs, an ultimate strength of 18.75 MPa, and an elastic modulus of 4.021 GPa, while for the G group, these values are 12.75 MPa, 18.84 MPa, and 4.076 GPa, respectively. The fatigue test was used to evaluate the failure characteristics of the socket. An F-socket was utilized to test the interface compression between both the limb and the socket. For the Tekscan sensor, the calculated pressure in the medial region is 350 K Pa, while it is 330 KPa in the posterior region. Solid Works software was used to draw a prosthetic socket for the numerical study. The failure safety agent for the composite material for group Y was 1.26. The finite element method (ANSYS Workbench 14.5) was used to look at the fatigue characteristics to detect the maximum stress, safety factor, and total deformation.

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Seroprevalence of Toxoplasma gondii and associated alterations in hematology and serum biochemistry of one-humped camels (Camelus dromedarius) in Pakistan

et al. 2022

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Background and Aim: Toxoplasma gondii is an intracellular protozoan that infects humans and animals. This study aimed to estimate the seroprevalence of T. gondii and the associated alterations in hematology and serum biochemistry of one-humped camels (Camelus dromedarius) in Mianwali district, Pakistan. Materials and Methods: A total of 350 blood samples were obtained from male and female camels of different ages (≤3 years old, 4-6 years old, and ≥7 years old). To validate T. gondii antibodies, the collected samples were subjected to indirect enzyme-linked immunosorbent assay using purified recombinant micronemal protein 3 as an antibody catching antigen. Results: The prevalence of T. gondii was 50.2% higher in male camels than in female camels (16.5%) (p<0.001). Furthermore, the prevalence of T. gondii in camels was directly proportional to age (p<0.001). It was 63.33% (57/90) in camels of ≥7 years of age, 32.54% in 4-6 years old age group, and 23.08% in ≤3 years old age group. The hematological analysis of infected camels revealed a significant increase in the values of glucocorticoid-remediable aldosteronism, lymphocyte percentage, monocyte percentage (MONO%), corpuscular hemoglobin (MCH), and procalcitonin. Furthermore, substantially higher levels of liver enzymes alanine aminotransferase, aspartate aminotransferase, and the macro-mineral potassium were found in the serum of T. gondii-infected camels. Conclusion: The seropositivity of T. gondii is directly associated with the age and sex of camels, which may be considered as potential risk factors. Furthermore, T. gondii infection directly impacts the hemato-biochemistry of infected camels.

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Biochemical study on the effect of Toxoplasma gondii on Liver function in Women

Cited by 3 publications

References 9 publications

Effect of Toxoplasmosis on hematological, biochemical and immunological parameters in pregnant women in Tikrit city, Iraq

Effect of Toxoplasmosis on hematological, biochemical and immunological parameters in pregnant women in Tikrit city, Iraq

Fatigue and Tensile Characteristics for Composite Materials Used in Prosthetic Socket

Seroprevalence of Toxoplasma gondii and associated alterations in hematology and serum biochemistry of one-humped camels (Camelus dromedarius) in Pakistan

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