Biochemical study on the protective effect of ethanolic extract of Zygophyllum album on streptozotocin-induced oxidative stress and toxicity in mice

Ghoul, J. El; Ghanem-Boughanmi, Néziha; Ben‐Attia, Mossadok

doi:10.1016/j.bionut.2010.10.001

Cited by 17 publications

(5 citation statements)

References 34 publications

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“…The leaves, stems, and fruits of this plant are used in the Tunisian folk medicine as a drug active against rheumatism, gout, and asthma. It is also used as diuretic, local anaesthetic, antihistaminic, and antidiabetic agent [17]. Therefore, this investigation was aimed to report the therapeutic effect of Zygophyllum album against hyperlipidemia and hypertension induced with a standardized high fat-diet (HFD) in female rats along with possible mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Activities ofZygophyllum album: A Natural Weight-Lowering Plant on Key Enzymes in High-Fat Diet-Fed Rats

Mnafgui

Hamden

Salah

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Obesity is a serious health problem that increased risk for many complications, including diabetes and cardiovascular disease. The results showed EZA, which found rich in flavonoids and phenolic compounds, exhibited an inhibitory activity on pancreatic lipase in vitro with IC50 of 91.07 μg/mL. In vivo administration of this extract to HFD-rats lowered body weight and serum leptin level; and inhibited lipase activity of obese rats by 37% leading to notable decrease of T-Ch, TGs and LDL-c levels accompanied with an increase in HDL-c concentration in serum and liver of EZA treated HFD-rats. Moreover, the findings revealed that EZA helped to protect liver tissue from the appearance of fatty cysts. Interestingly, supplementation of EZA modulated key enzyme related to hypertension such as ACE by 36% in serum of HFD animals and improve some of serum electrolytes such as Na+, K+, Cl−, Ca2+ and Mg2+. Moreover, EZA significantly protected the liver-kidney function by reverted back near to normal the values of the liver-kidney dysfunction indices AST&ALT, ALP, CPK and GGT activities, decreased T-Bili, creat, urea and uric acid rates. In conclusion, these results showed a strong antihypelipidemic effect of EZA which can delay the occurrence of dislipidemia and hypertension.

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Section: Introductionmentioning

confidence: 99%

Inhibitory Activities ofZygophyllum album: A Natural Weight-Lowering Plant on Key Enzymes in High-Fat Diet-Fed Rats

Mnafgui

Hamden

Salah

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…32 Their richness in various chemicals permits different mechanisms of action to lower blood sugar's concentration such as, stimulating insulin secretion, inhibiting amylase, glucosidase and phospho-fructokinases, and facilitating glucose uptake by cells. [27][28][29][30][31][32][33][34][35] Substances contained in medicinal herbs', essentially polyphenols and flavonoids, are also known to repress oxidative stress that mediates cellular damages and forms a cross-link mechanism for developing associated health disorders. 25 Obviously, most of these herbs are considered as generally safe and can improve many types of metabolic disorders.…”

Section: Resultsmentioning

confidence: 99%

Diabetes ethnopharmacology in rural region: study of a case report and review of literature

Jamal¹,

Bouzenna²,

Abir³

et al. 2022

EMIJ

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Recently, there is an ascendant recourse for medicinal plants’ utilization as treatment of several chronic diseases, including diabetes. While effective in wound healing, some herbs might present toxic effects at certain doses or when used for long periods. In this study, the frequently used antidiabetic herbs, in a rural region, was reviewed with special focus on their possible toxicological features

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“…Other studies have reported a toxic effect of certain medicinal plants in the pathology of diabetes: Zygophyllum album [28], Nigella sativa [29], Nerium oleander [30].…”

Section: Introductionmentioning

confidence: 98%

Diabetes mellitus quality care management: The promise of herbal supplementation

Arar¹,

A²

2021

GSC Adv. Res. Rev.

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Overcoming diabetes is a major health challenge of the 21st century. WHO predicts that by 2030 it will be the seventh leading cause of death in the world and calls for global action to stop its rise and improve care. Actually, Herbal and nutritional supplementation is required in the management of diabetic patients, a finding shared unanimously by scientists. Recently diabetologists have come to the evidence that a therapeutic supplement consisting of nutrients and herbal is necessary to optimize the treatment of diabetes. The treatment of Type 2 diabetes mellitus, which is very often associated with overweight, is based on hygiene and dietetic measures and, where appropriate, on taking oral antidiabetics .This review describes the therapeutic arsenal of conventional oral antidiabetic drugs and emphasizes on innovative therapeutic option introducing herbal medicine and nutrition to the management of diabetic patients. Recent studies showed interesting potential in the reduction of blood sugar for many herbal for example Cinnamon, also berberine has been linked to the reduction of blood glucose levels, insulin levels and showed to be as effective as metformin, the most commonly prescribed drug for diabetics, at controlling blood sugar levels in diabetics. Moreover, a medicinal plant or herbal mixture can provide multi-targeted therapeutic action due to its complex chemical composition with hundreds of active ingredients such as oligosaccharides, alkaloids, polyphenols, flavonoids, tannins and at the same time ensure safety for the patients. We conclude by the fact that herbal and nutritional supplementation can bring major and promising progress in order to improve the patient care, by slowing the progression of type 2 diabetes and limiting its complications.

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Biochemical study on the protective effect of ethanolic extract of Zygophyllum album on streptozotocin-induced oxidative stress and toxicity in mice

Cited by 17 publications

References 34 publications

Inhibitory Activities ofZygophyllum album: A Natural Weight-Lowering Plant on Key Enzymes in High-Fat Diet-Fed Rats

Inhibitory Activities ofZygophyllum album: A Natural Weight-Lowering Plant on Key Enzymes in High-Fat Diet-Fed Rats

Diabetes ethnopharmacology in rural region: study of a case report and review of literature

Diabetes mellitus quality care management: The promise of herbal supplementation

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