Biocide loaded shear-thinning hydrogel with anti-biofilm efficacy cures topical infection

Abstract

The Continuous intervention of multidrug-resistant (MDR) bacterial infections worsens and sluggish the dynamicity of natural wound healing processes. Fortunately, antibiotics, metal ions, or metal nanoparticle-loaded antimicrobial hydrogel were developed to...

Hydrogel-based dressings designed to facilitate wound healing

“…To address this issue, researchers have successfully developed various novel and effective antimicrobial hydrogels. [281][282][283] Cai et al developed a eucalyptus essential oil nanoemulsion hydrogel specifically for this purpose. In vitro experiments demonstrated that the hydrogel displayed strong antimicrobial activity and inhibited biofilm formation.…”

Unveiling the potent activity of a synthetic ion transporter against multidrug-resistant Gram-positive bacteria and biofilms

“…4.9 Bacterial live/dead assay 42 1 mL of 10 8 CFU mL −1 midlog phase MRSA suspension in 1× PBS was mixed with the compound T, and the mixture was incubated at 37 °C. The bacterial suspension was centrifuged to extract the compound entirely after 6 h of incubation.…”

Stimuli-Responsive Release-Active Dressing: A Promising Solution for Eradicating Biofilm-Mediated Wound Infections

“…Release Kinetics of Small Antibacterial Molecule SAM-17. 44 This release kinetics of SAM-17 was measured through reverse phase (RP) HPLC. 2.5 cm diameter film was sealed in a 2 kDa cut-off dialysis membrane and then was immersed in 5 mL of different pH solutions (pH = 5.5 and pH = 7.2).…”

“…Zone of Inhibition. 44 Briefly, 100 μL of 1 × 10 7 CFU/mL mid-log phases grown bacterial suspension was spread over the solid agar medium. Then, 8 mm diameter and 2 mm thick films (CHF-0 and CHF-0.1) were located at the center of the contaminated agar plate after the exclusion of a same diameter circular agar portion.…”

“…LIVE/DEAD Assay of the Film Treated Bacteria. 44 500 μL of fresh 1 × 10 8 CFU/mL MRSA R3545 bacterial suspensions in saline was incubated with a 16 mm diameter film for 2 h at 37 °C. After that, the bacteria were harvested by centrifuging at 5000 rpm for 10 min at 4 °C.…”