Biocompatibility of polymer-coated oversized metallic stents implanted in normal porcine coronary arteries

Scheerder, Ivan K. De; Wilczek, Krzysztof; Verbeken, Eric; Vandorpe, Joke; Lan, Pham Ngoc; Schacht, Etienne; Geest, H De; Piessens, Jan

doi:10.1016/0021-9150(94)05472-u

Cited by 103 publications

(61 citation statements)

References 14 publications

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“…As has been observed by others, 19,20 an inflammatory response to the stent was noted (Figure 3). Based upon observation of multiple tissue sections stained with hematoxylin and eosin, inflammation appeared to be predominantly influenced by the extent of tissue damage by the stent strut, rather than the presence or absence of polymer.…”

Section: Introductionsupporting

confidence: 84%

“…Here, a DNA/polymer emulsion was used to coat stainlesssteel stents, the stents were delivered to rabbit external iliac arteries, and gene transfer was evaluated at 7 days after implantation. At this timepoint, we did not observe 20 With three different plasmid-encoded marker genes, luciferase, b-galactosidase and GFP, we defined the elution and transfection characteristics of this polymer coating.…”

Section: Discussionmentioning

confidence: 94%

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Transgene delivery of plasmid DNA to smooth muscle cells and macrophages from a biostable polymer-coated stent

Takahashi

Palmer-Opolski²,

Smith

et al. 2003

Gene Ther

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Metallic stents coated with a polyurethane emulsion containing plasmid DNA were implanted in rabbit iliac arteries to evaluate transgene delivery and expression in the vessel wall. The expression of the plasmid-encoded marker genes, b-galactosidase, luciferase and green fluorescence protein (GFP), were evaluated at 7 days after implantation. In all cases, plasmid transfer was confined to the vessel wall at the site of stent implantation, plasmid DNA was not observed in vessel segments immediately proximal or distal to the stent and dissemination of plasmid DNA to lung, liver or spleen was not observed. Expression of transgenes occurred only in vessel segments in contact with the stent and analysis of the GFP expression pattern revealed a high frequency of marker protein-positive cells occurring at or near the luminal surface. The extent of transgene expression was dependent upon the quantity of DNA loaded onto the stent and no signal was detected in vessel segments that received polymer-coated stents lacking plasmid DNA. Of significance, colocalization studies identified transgene expression not only in vascular smooth muscle cells but also in macrophages. Hence, polymer-coated stents provide a new capability for transgene delivery to immune cells that are believed to contribute to the development of in-stent restenosis.

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Section: Introductionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 94%

Transgene delivery of plasmid DNA to smooth muscle cells and macrophages from a biostable polymer-coated stent

Takahashi

Palmer-Opolski²,

Smith

et al. 2003

Gene Ther

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show abstract

“…9 An experimental animal model has shown a continuous inflammatory response (IR) in NIH and the vessel wall after DES implantation compared with BMS and, moreover, it has been demonstrated that late malapposition and the invasion of inflammatory cells occur in the peri-stent area in postmortem cases with evidence of stent thrombosis, suggesting that there is a causal relationship among stent thrombosis and late malapposition and vessel inflammation response. [10][11][12] Optical coherence tomography (OCT) is a recently developed invasive and intravascular diagnostic imaging modality that emits near infrared rays from optical fibers, which are…”

mentioning

confidence: 99%

Morphological and Quantitative Analysis of Vascular Wall and Neointimal Hyperplasia After Coronary Stenting - Comparison of Bare-Metal and Sirolimus-Eluting Stents Using Optical Coherence Tomography -

Goto

Itoh

Kimura

et al. 2011

Circ J

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he coronary bare metal stent (BMS) system decreases the incidence of restenosis in the convalescent phase, in addition to preventing the occurrence of an acute occlusion immediately following percutaneous coronary intervention (PCI). 1,2 However, 15% patients require repeat PCI due to in-stent restenosis. To resolve this issue, drug-eluting stents (DES) were developed and a sirolimus-eluting stent (SES) has started to be used in the clinical setting. Several clinical trials have shown a greater reduction in the incidence of in-stent restenosis with this system compared with a BMS, 3-7 and the use of DES has spread rapidly.However, it has been noted that, following DES implantation, there is delayed healing of the vessel wall, together with inhibition of neointimal hyperplasia (NIH) and continuation of the inflammation response; these phenomena have led to concerns about the possible increased risk of stent thrombosis during the convalescent phase. Indeed, 4 cases of very late stent thrombosis, 1 year after DES implantation, have been reported; 8 a previous study has demonstrated that the rate of stent thrombosis gradually increased by 0.2-0.6%/year. 9 An experimental animal model has shown a continuous inflammatory response (IR) in NIH and the vessel wall after DES implantation compared with BMS and, moreover, it has been demonstrated that late malapposition and the invasion of inflammatory cells occur in the peri-stent area in postmortem cases with evidence of stent thrombosis, suggesting that there is a causal relationship among stent thrombosis and late malapposition and vessel inflammation response. 10-12Optical coherence tomography (OCT) is a recently developed invasive and intravascular diagnostic imaging modality that emits near infrared rays from optical fibers, which are Background: It has been suggested that sirolimus-eluting stents (SES) provoke a more sustained inflammatory response (IR) in neointimal hyperplasia (NIH). The purpose of this study was to compare morphological vessel characteristics, including post-stent IR in NIH, between patients with SES and bare metal stents (BMS) using optical coherence tomography (OCT).

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“…These findings are in agreement with previous observations [23,24,26] showing that contact of the stent surface polymer coating with the vessel wall does not affect vascular injury or neointimal thickening. Similarly, De Scheerder et al [27] found that neither angiographic luminal diameter nor postmortem luminal stenosis differed between groups treated with polyurethane-coated and bare metallic stents. It is noteworthy, however, that a relatively modest tissue reaction toward polyurethane-coated stents as compared with polyphosphazene-coated stents was encountered in their study.…”

Section: Discussionmentioning

confidence: 93%

Biocompatibility of polyurethane-coated stents: Tissue and vascular aspects

Rechavia

Litvack

Fishbien

et al. 1998

Cathet. Cardiovasc. Diagn.

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Biocompatibility of polymer-coated oversized metallic stents implanted in normal porcine coronary arteries

Cited by 103 publications

References 14 publications

Transgene delivery of plasmid DNA to smooth muscle cells and macrophages from a biostable polymer-coated stent

Transgene delivery of plasmid DNA to smooth muscle cells and macrophages from a biostable polymer-coated stent

Morphological and Quantitative Analysis of Vascular Wall and Neointimal Hyperplasia After Coronary Stenting - Comparison of Bare-Metal and Sirolimus-Eluting Stents Using Optical Coherence Tomography -

Biocompatibility of polyurethane-coated stents: Tissue and vascular aspects

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