Biocompatibility of Resin-based Dental Materials

Moharamzadeh, Keyvan; Brook, Ian M.; Noort, Richard van

doi:10.3390/ma2020514

Cited by 87 publications

(87 citation statements)

References 189 publications

(293 reference statements)

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“…Biocompatibility is the material's ability to function in a host tissue without causing any adverse reaction [79]. Cytotoxicity describes the cascade of molecular events that causes either cellular or functional damage [80].…”

Section: Cytotoxicitymentioning

confidence: 99%

“…Fibroblasts are the most commonly used cells in testing the biocompatibility of new dental materials [88]. They can be isolated from patients easily and they can grow in regular culture media, although cell lines such as L-929 and 3T3 mouse fibroblasts are used frequently [79]. Many in vitro tests can be conducted to evaluate the cytotoxicity.…”

Section: Cytotoxicitymentioning

confidence: 99%

“…Future studies should examine their biocompatibility in vivo. Animal model for dental materials biocompatibility testing includes rats, rabbits, dogs and non-human primates [79,135]. Favorable outcomes in animal models could then lead to an application to Health Canada to undertake clinical trials in humans.…”

Section: Future Directionsmentioning

confidence: 99%

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Section: Cytotoxicitymentioning

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confidence: 99%

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“…These cells are frequently used in biological assessment of resin based materials because they are in close proximity with restorative dental materials in the oral cavity, more clinically relevant and are sensitive cells easy to isolate. [17][18][19]22] These free monomers alter cell functions in the oral cavity.…”

Section: Growth and Maintenance Of Cell Culturesmentioning

confidence: 99%

Determination of cytotoxicity of dentine bonding agents, hydroxyethyl methacrylate and bisphenol alpha

Reddy¹

2017

IDJAR

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Aim:The purpose of the study was to analyze cytotoxicity caused by dental adhesives on human gingival fibroblast (HGF) cell lines, compare the response of cultured HGFs to substances leached from a conventional total etch and self-etching adhesive system along with their individual components. Methodology: Healthy gingival tissue biopsies (explants) were used to obtain isolates of HGFs, which were cultivated in flasks till subconfluent monolayers obtained. Serial dilutions for each compound tested were made and elutes at all concentrations tested for were obtained at 48 h for each material which were then added at different concentrations to the HGF cultures, and cytotoxicity was analyzed by 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: Within the limitations of the in-vitro study, we conclude: All of the materials tested showed moderately or slightly cytotoxicity at the lower serial dilutions except bisphenol alpha and One Coat-7.0, which proved to be strongly cytotoxic among almost all the dilutions. The lowest cytotoxicity was obtained from Clearfil SE Bond at 0.3125 mg/mL and the highest from One Coat-7.0 at 5.9 mg/mL, among the three dentin bonding systems tested for cytotoxicity. Conclusions: Indicated that SE B had the lowest mean % of cell viability value and OC had the highest mean % of cell viability.

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“…Each dental material must be biocompatible or able to function in vivo without eliciting an intolerable response in the body either locally or systemically. There are only few materials for which could be said that are biologically inert since most of them contain a potentially harmful or irritating ingredients [9,21].…”

Section: Biocompatibility Of Dental Materialsmentioning

confidence: 99%

Biocompatibility of Dental Adhesives

Tadin¹,

Gavić²,

Galić³

2016

Adhesives - Applications and Properties

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The accomplishment of developing a truly adhesive bond between a restorative material and the natural tooth structures is the goal of adhesive dentistry. Dentine adhesive systems come into close contact with dental and oral tissue, especially the pulp and gingival cells. Due to this close and long-term contact, adhesives should exhibit a high degree of biocompatibility. "iocompatibility is one of the most important properties of dental materials, and adhesives are no exception. It has been long demonstrated that diferent components of adhesives can be released. Numerous in vitro investigations have shown that released monomers and other components can cause damage to cultured cells. In addition, many in vivo studies have shown that uncured components which reach the pulpal space cause inlammatory response and tissue disorganization. Only a combination of various in vitro and in vivo tests can provide an overview of the interaction of biomaterials with the host. Therefore, it is necessary on a regular basis to carry out and re-verify the biological compatibility of the increasing number of new dental materials. "dhesives should be biofunctional, protective, and preventive, with health-promoting efects that contribute to a beter prognosis for restorative treatments and its biocompatibility.

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Biocompatibility of Resin-based Dental Materials

Cited by 87 publications

References 189 publications

Reinforcement of flowable dental composites with titanium dioxide nanotubes

Reinforcement of flowable dental composites with titanium dioxide nanotubes

Determination of cytotoxicity of dentine bonding agents, hydroxyethyl methacrylate and bisphenol alpha

Biocompatibility of Dental Adhesives

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