Biocompatible and biodegradable scaffold based on polytrimethylene carbonate-tricalcium phosphate microspheres for tissue engineering

He, Jian; Lin, Ziying; Hu, Xulin; Lin, Xiaodong; Liang, Guozheng; Chen, Dongliang; An, Jun-Ling; Xiong, Chengdong; Zhang, Xiangchun; Zhang, Lifang

doi:10.1016/j.colsurfb.2021.111808

Cited by 11 publications

(5 citation statements)

References 42 publications

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“…Microspheres are ideal carrier materials due to their large surface and volume, which allow them to carry and release drugs. 151 , 152 In general, any surgical procedure has a potential risk of inflammation and bone infection, which traditionally needs to be prevented by prolonged (2–6 weeks) antibiotic treatment, 153 , 154 and the recovery of bone tissue is a long process. The sustained release of microsphere-loaded growth factors can promote osteogenesis.…”

Section: Drug-loaded Bone Scaffoldsmentioning

confidence: 99%

“…[168][169][170] Moreover, some studies have shown that the performance of microspheres (drug loading efficiency and encapsulation efficiency) is much higher than that of inorganic nanoparticles. 152,171 In addition, microspheres can be designed as a stimuliresponsive drug-release system. Different media conditions lead to different degradability and different release behavior.…”

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confidence: 99%

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Research Progress of Design Drugs and Composite Biomaterials in Bone Tissue Engineering

Guo¹,

Song²,

Lu³

et al. 2023

IJN

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Bone, like most organs, has the ability to heal naturally and can be repaired slowly when it is slightly injured. However, in the case of bone defects caused by diseases or large shocks, surgical intervention and treatment of bone substitutes are needed, and drugs are actively matched to promote osteogenesis or prevent infection. Oral administration or injection for systemic therapy is a common way of administration in clinic, although it is not suitable for the long treatment cycle of bone tissue, and the drugs cannot exert the greatest effect or even produce toxic and side effects. In order to solve this problem, the structure or carrier simulating natural bone tissue is constructed to control the loading or release of the preparation with osteogenic potential, thus accelerating the repair of bone defect. Bioactive materials provide potential advantages for bone tissue regeneration, such as physical support, cell coverage and growth factors. In this review, we discuss the application of bone scaffolds with different structural characteristics made of polymers, ceramics and other composite materials in bone regeneration engineering and drug release, and look forward to its prospect.

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Section: Drug-loaded Bone Scaffoldsmentioning

confidence: 99%

mentioning

confidence: 99%

Research Progress of Design Drugs and Composite Biomaterials in Bone Tissue Engineering

Guo¹,

Song²,

Lu³

et al. 2023

IJN

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“…Its exceptional biocompatibility and biodegradability ( Hou et al, 2020 ), coupled with the absence of acidic degradation products during breakdown, effectively prevent severe inflammatory reactions ( Yang et al, 2014 ; Yang et al, 2015 ). This versatility renders PTMC a valuable material in various biomedical applications, including drug delivery systems ( Mohajeri et al, 2020 ; Hou et al, 2023 ) and tissue engineering ( Li et al, 2020 ; Brossier et al, 2021 ; He et al, 2021 ), among others. In recent studies, researchers have explored hybrid polymers that combine PCL and PTMC as biodegradable coatings on Mg alloy stents, with promising results ( Yuan et al, 2016 ).…”

Section: Materials Used In Biodegradable Esophageal Stentsmentioning

confidence: 99%

Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents

Yang,

Hou

et al. 2023

Front. Bioeng. Biotechnol.

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Esophageal stricture (ES) results from benign and malignant conditions, such as uncontrolled gastroesophageal reflux disease (GERD) and esophageal neoplasms. Upper gastrointestinal endoscopy is the preferred diagnostic approach for ES and its underlying causes. Stent insertion using an endoscope is a prevalent method for alleviating or treating ES. Nevertheless, the widely used self-expandable metal stents (SEMS) and self-expandable plastic stents (SEPS) can result in complications such as migration and restenosis. Furthermore, they necessitate secondary extraction in cases of benign esophageal stricture (BES), rendering them unsatisfactory for clinical requirements. Over the past 3 decades, significant attention has been devoted to biodegradable materials, including synthetic polyester polymers and magnesium-based alloys, owing to their exceptional biocompatibility and biodegradability while addressing the challenges associated with recurring procedures after BES resolves. Novel esophageal stents have been developed and are undergoing experimental and clinical trials. Drug-eluting stents (DES) with drug-loading and drug-releasing capabilities are currently a research focal point, offering more efficient and precise ES treatments. Functional innovations have been investigated to optimize stent performance, including unidirectional drug-release and anti-migration features. Emerging manufacturing technologies such as three-dimensional (3D) printing and new biodegradable materials such as hydrogels have also contributed to the innovation of esophageal stents. The ultimate objective of the research and development of these materials is their clinical application in the treatment of ES and other benign conditions and the palliative treatment of malignant esophageal stricture (MES). This review aimed to offer a comprehensive overview of current biodegradable esophageal stent materials and their applications, highlight current research limitations and innovations, and offer insights into future development priorities and directions.

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“…However, the degradation mechanism depends on multiple factors related to both the material (e.g., crystallinity and molecular weight) and topological (e.g., pore size and pore shape) characteristics of scaffolds, which are not fully understood. Several papers have been published based on rectangular or cylindrical scaffolds, investigating the effect of pore size and pore architecture and material composition [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. However, a comparison of the degradation kinetics of polymer/ceramic scaffolds containing different ceramic materials (e.g., hydroxyapatite (HA), β-tricalcium phosphate (TCP) and bioglass) is still missing.…”

Section: Introductionmentioning

confidence: 99%

Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defects

et al. 2023

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This research investigates the accelerated hydrolytic degradation process of both anatomically designed bone scaffolds with a pore size gradient and a rectangular shape (biomimetically designed scaffolds or bone bricks). The effect of material composition is investigated considering poly-ε-caprolactone (PCL) as the main scaffold material, reinforced with ceramics such as hydroxyapatite (HA), β-tricalcium phosphate (TCP) and bioglass at a concentration of 20 wt%. In the case of rectangular scaffolds, the effect of pore size (200 μm, 300 μm and 500 μm) is also investigated. The degradation process (accelerated degradation) was investigated during a period of 5 days in a sodium hydroxide (NaOH) medium. Degraded bone bricks and rectangular scaffolds were measured each day to evaluate the weight loss of the samples, which were also morphologically, thermally, chemically and mechanically assessed. The results show that the PCL/bioglass bone brick scaffolds exhibited faster degradation kinetics in comparison with the PCL, PCL/HA and PCL/TCP bone bricks. Furthermore, the degradation kinetics of rectangular scaffolds increased by increasing the pore size from 500 μm to 200 μm. The results also indicate that, for the same material composition, bone bricks degrade slower compared with rectangular scaffolds. The scanning electron microscopy (SEM) images show that the degradation process was faster on the external regions of the bone brick scaffolds (600 μm pore size) compared with the internal regions (200 μm pore size). The thermal gravimetric analysis (TGA) results show that the ceramic concentration remained constant throughout the degradation process, while differential scanning calorimetry (DSC) results show that all scaffolds exhibited a reduction in crystallinity (Xc), enthalpy (Δm) and melting temperature (Tm) throughout the degradation process, while the glass transition temperature (Tg) slightly increased. Finally, the compression results show that the mechanical properties decreased during the degradation process, with PCL/bioglass bone bricks and rectangular scaffolds presenting higher mechanical properties with the same design in comparison with the other materials.

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Biocompatible and biodegradable scaffold based on polytrimethylene carbonate-tricalcium phosphate microspheres for tissue engineering

Cited by 11 publications

References 42 publications

Research Progress of Design Drugs and Composite Biomaterials in Bone Tissue Engineering

Research Progress of Design Drugs and Composite Biomaterials in Bone Tissue Engineering

Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents

Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defects

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