Biocompatible and optically stable hydrophobic fluorescent carbon dots for isolation and imaging of lipid rafts in model membrane

Chatterjee, Arunavo; Ruturaj,; Chakraborty, Manas Pratim; Nandi, Sukhendu; Purkayastha, Pradipta

doi:10.1007/s00216-022-04165-6

Cited by 4 publications

(5 citation statements)

References 95 publications

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“…Recent studies have found that embedding LW-CDs into a rigid matrix Y(OH) x F 3-x can significantly improve their photostability, thermal stability, chemical stability and temporal stability 125 . Similarly, embedding LW-CDs into the lipid bilayer of giant unilamellar vesicles can recover within 5 s after photobleaching and maintain photostability 126 . In order to probe the relevant mechanisms of fluorescence stability, Terracina et al investigated the photostability of LW-CDs by in situ observing their time-resolved fluorescence degradation or light absorption changes under equivalent experimental conditions and laser irradiation.…”

Section: General Properties Of Lw-cds For In Vivo ...mentioning

confidence: 99%

Recent progress of emitting long-wavelength carbon dots and their merits for visualization tracking, target delivery and theranostics

Li¹,

Huang²,

Yuan³

et al. 2023

Theranostics

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As a novel strategy for in vivo visualization tracking and monitoring, carbon dots (CDs) emitting long wavelengths (LW, 600-950 nm) have received tremendous attention due to their deep tissue penetration, low photon scattering, satisfactory contrast resolution and high signal-to-background ratios. Although, the mechanism of CDs emitting LW remains controversial and what properties are best for in vivo visualization have not been specifically elucidated, it is more conducive to the in vivo application of LW-CDs through rational design and ingenious synthesis based on the appreciation of the luminescence mechanism. Therefore, this review analyzes the current tracer technologies applied in vivo and their advantages and disadvantages, with emphasis on the physical mechanism of emitting LW fluorescence for in vivo imaging. Subsequently, the general properties and merits of LW-CDs for tracking and imaging are summarized. More importantly, the factors affecting the synthesis of LW-CDs and its luminescence mechanism are highlighted. Simultaneously, the application of LW-CDs for disease diagnosis, integration of diagnosis and therapy are summarized. Finally, the bottlenecks and possible future directions of LW-CDs in visualization tracking and imaging in vivo are detailly discussed.

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Section: General Properties Of Lw-cds For In Vivo ...mentioning

confidence: 99%

Recent progress of emitting long-wavelength carbon dots and their merits for visualization tracking, target delivery and theranostics

Li¹,

Huang²,

Yuan³

et al. 2023

Theranostics

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“…These are used nowadays to replace the comparatively expensive and less stable liposomes. , However, their stability allows the interfacial characteristics of niosomes to be tuned based on the requirements. The photophysical properties of the interfacial drugs bound to the niosomes have been a very important topic in present day research. − Moreover, sheltering nanomaterials in the lipid and niosomal interfaces for biomarking and energy research has recently been put into practice. − Nandi et al used carbon nanoparticles (CNPs) to analyze and probe the membrane, , and Chatterjee et al used them to mark the lipid rafts . That the niosomal interface can be utilized in CNP-driven energy-harvester generation and reactive oxygen species (ROS) detection was shown for the first time by Chatterjee et al…”

Section: Importance Of Interfacial Interactionsmentioning

confidence: 99%

“…37−40 37,38 and Chatterjee et al used them to mark the lipid rafts. 39 That the niosomal interface can be utilized in CNP-driven energy-harvester generation and reactive oxygen species (ROS) detection was shown for the first time by Chatterjee et al 40 In the discussion on interfaces, interactions between proteins, small molecules, and DNA cannot be averted. One topic of outstanding importance is the phenomena at the protein−DNA interfaces.…”

Section: Importance Of Interfacial Water In the Chemicalmentioning

confidence: 99%

Events at the Interface: How Do Interfaces Modulate the Dynamics and Functionalities of Guest Molecules?

Chatterjee

Purkayastha

2022

Langmuir

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Chemical and biological interfaces are of various types, which could be between two materials of the same and/or different states, two phases of the same material, biological substrates and the outer environment, surfactant or polymeric membranes and the bulk, and so forth. Small-molecule guests frequently interact with such interfaces that decide their functionalities. The structural and behavioral properties undergo considerable characteristic changes, which control their final course of action in the targeted application. This Perspective will discuss mainly the chemical interfaces constituted by the surfactants, polymers, lipids, and nucleic acids and their impacts on the dynamics of small-molecule guests. Some specific and interesting phenomena and future prospects will be elucidated in this Perspective.

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“…45−47 Hybrid systems consisting of phospholipids and highly fluorescent CDs have already been successfully applied to research on liposomes, e.g., to investigate the bilayer dynamics 19,48 and formation of lipid rafts. 49 A previous study on MFs formed in aqueous medium doped with latex microspheres has revealed that microparticles do not penetrate the lamellar phase; however, they can be applied as tracers to monitor the mechanism of the MFs' growth. 50 Accordingly, the use of CNDs with the above-mentioned properties may unlock new possibilities for doping and imaging of bioinspired cylindrical multilamellar structures.…”

Section: Introductionmentioning

confidence: 99%

Strongly Emitting Folic Acid-Derived Carbon Nanodots for One- and Two-Photon Imaging of Lyotropic Myelin Figures

Benkowska-Biernacka

Mucha

Firlej

et al. 2023

ACS Appl. Mater. Interfaces

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Non-invasive imaging of morphological changes in biologically relevant lipidic mesophases is essential for the understanding of membrane-mediated processes. However, its methodological aspects need to be further explored, with particular attention paid to the design of new excellent fluorescent probes. Here, we have demonstrated that bright and biocompatible folic acid-derived carbon nanodots (FA CNDs) may be successfully applied as fluorescent markers in one- and two-photon imaging of bioinspired myelin figures (MFs). Structural and optical properties of these new FA CNDs were first extensively characterized; they revealed remarkable fluorescence performance in linear and non-linear excitation regimes, justifying further applications. Then, confocal fluorescence microscopy and two-photon excited fluorescence microscopy were used to investigate a three-dimensional distribution of FA CNDs within the phospholipid-based MFs. Our results showed that FA CNDs are effective markers for imaging various forms and parts of multilamellar microstructures.

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Biocompatible and optically stable hydrophobic fluorescent carbon dots for isolation and imaging of lipid rafts in model membrane

Cited by 4 publications

References 95 publications

Recent progress of emitting long-wavelength carbon dots and their merits for visualization tracking, target delivery and theranostics

Recent progress of emitting long-wavelength carbon dots and their merits for visualization tracking, target delivery and theranostics

Events at the Interface: How Do Interfaces Modulate the Dynamics and Functionalities of Guest Molecules?

Strongly Emitting Folic Acid-Derived Carbon Nanodots for One- and Two-Photon Imaging of Lyotropic Myelin Figures

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