Biocompatible, Antifouling, and Thermosensitive Core−Shell Nanogels Synthesized by RAFT Aqueous Dispersion Polymerization

Shen, Wenqing; Chang, Ya-Wen; Liu, Guangyao; Wang, Haifang; Cao, Aoneng; An, Zesheng

doi:10.1021/ma200074n

Cited by 213 publications

(207 citation statements)

References 59 publications

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“…Nonetheless, the (RAFT) polymerization induced selfassembly and the factors which control what structure is formed have recently attracted considerable interest with studies on the phenomenon in emulsion polymerization, [354,381,400] dispersion polymerization [187,224,229,353,361,571] and non-aqueous dispersion polymerization. [394,397] Blanazs et al [187] have constructed a phase diagram for poly(288)-poly(HPMA).…”

Section: Raft Polymerization In Heterogeneous Mediamentioning

confidence: 99%

“…DMAm [348] DMAm-b-HEAm [348] 97 n ϭ 1 or 2 [349,350] DEAEMA [351] DMAEMA [350,352] PEGMA [224,[353][354][355] (412) [243] PAA [356] DMAm [326] DMAm [326] HPMAm [357] 357 [357] MAA/PEGMA [354] APMAm/DEAPMAm [358] APMAm/DMAPMAm [358] DEAEMA-bNIPAm [351] DMEAEMA-b-NIPAm [359] PEGMA/MAA-b-St [354,360] PEGMA/MAA-bBzMA [361] PEGMA/MAA-b-327 [362] PAA-bDMAm/408 [356] DMAEMA-b-(PAA/BMA/ DMAEMA) [350,352] HPMAm/450/451 [363] HPMAm-b-357 [357] 98 [364] 317 [311] 332 [365] 333 [365] DMAm [366] BA [366] 350 [311] NIPAm [366,367] MAA/ MMA [368] MAA/DFHA [369] OeMA/MMA [364] 332-b-MMA [365] 333-b-MMA [365] NIPAm-bDMAEAm [367] 99…”

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confidence: 99%

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Living Radical Polymerization by the RAFT Process – A Third Update

2012

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This paper provides a third update to the review of reversible deactivation radical polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC(¼S)SR) by a mechanism of reversible addition-fragmentation chain transfer ( Chem. 2009Chem. , 62, 1402. This review cites over 700 publications that appeared during the period mid 2009 to early 2012 covering various aspects of RAFT polymerization which include reagent synthesis and properties, kinetics and mechanism of polymerization, novel polymer syntheses, and a diverse range of applications. This period has witnessed further significant developments, particularly in the areas of novel RAFT agents, techniques for end-group transformation, the production of micro/nanoparticles and modified surfaces, and biopolymer conjugates both for therapeutic and diagnostic applications.

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Section: Raft Polymerization In Heterogeneous Mediamentioning

confidence: 99%

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confidence: 99%

Living Radical Polymerization by the RAFT Process – A Third Update

2012

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“…An et al have reported the aqueous dispersion RAFT polymerization mediated with either linear poly(ethylene glycol) or graft poly(poly(ethylene glycol) methyl ether methacrylate) macro-RAFT agent. [32][33][34][35] Recently, Armes and coworkers have studied a series of aqueous dispersion RAFT polymerizations of 2-hydroxypropyl methacrylate mediated with different macro-RAFT agents, and multimorphologies like spheres, worms, vesicles, or lumpy rods have been prepared. [36][37][38][39][40][41][42] Presumably, the lack of aqueous dispersion RAFT polymerization is ascribed to the reason that relatively few water-soluble monomers can form water-insoluble polymers, which is an essential prerequisite for aqueous dispersion RAFT polymerization.…”

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confidence: 99%

Aqueous RAFT polymerization of N‐isopropylacrylamide‐mediated with hydrophilic macro‐RAFT agent: Homogeneous or heterogeneous polymerization?

Wang¹,

Li²,

Su³

et al. 2013

J. Polym. Sci. A Polym. Chem.

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Aqueous RAFT polymerization of N-isopropylacrylamide (NIPAM) mediated with hydrophilic macro-RAFT agent is generally used to prepare poly(N-isopropylacrylamide) (PNI-PAM)-based block copolymer. Because of the phase transition temperature of the block copolymer in water being dependent on the chain length of the PNIPAM block, the aqueous RAFT polymerization is much more complex than expected. Herein, the aqueous RAFT polymerization of NIPAM in the presence of the hydrophilic macro-RAFT agent of poly(dimethylacrylamide) trithiocarbonate is studied and compared with the homogeneous solution RAFT polymerization. This aqueous RAFT polymerization leads to the well-defined poly(dimethylacrylamide)-b-poly(N-isopropylacrylamide)-b-poly(dimethylacrylamide) (PDMA-b-PNIPAM-b-PDMA) triblock copolymer. It is found, when the triblock copolymer contains a short PNIPAM block, the aqueous RAFT polymerization undergoes just like the homogeneous one; whereas when the triblock copolymer contains a long PNIPAM block, both the initial homogeneous polymerization and the subsequent dispersion polymerization are involved and the two-stage ln ([M] o /[M])-time plots are indicated. The reason that the PNIPAM chain length greatly affects the aqueous RAFT polymerization is discussed. The present study is anticipated to be helpful to understand the chain extension of thermoresponsive block copolymer during aqueous RAFT polymerization.

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“…157,176,177 Furthermore, there is increasing attention toward crosslinking polymers during amphiphilic block copolymer synthesis to lock-in morphologies and afford nano/microgels and macrohydrogels with responsive properties. [205][206][207]225 …”

Section: F Amphiphilic Block Copolymer Synthesis: Discussionmentioning

confidence: 99%

Block copolymer synthesis by controlled/living radical polymerisation in heterogeneous systems

et al. 2016

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Nanostructured soft materials open up new opportunities in material design and application, and block copolymer self-assembly is one particularly powerful phenomenon that can be exploited for their synthesis. The advent of controlled/living radical polymerisation (CLRP) has greatly simplified block copolymer synthesis, and versatility towards monomer types and polymer architectures across the different forms of CLRP has vastly expanded the range of functional materials accessible. CLRP-controlled synthesis of block copolymers has been applied in heterogeneous systems, motivated by the numerous process advantages and the position of emulsion polymerisation at the forefront of industrial latex synthesis. In addition to the inherent environmental advantages of heterogeneous routes, the incidence of block copolymer self-assembly within dispersed particles during polymerisation leads to novel nanostructured materials that offer enticing prospects for entirely new applications of block copolymers. Here, we review the range of block copolymers prepared by heterogeneous CLRP techniques, evaluate the methods applied to maximise purity of the products, and summarise the unique nanoscale morphologies resulting from in situ self-assembly, before discussing future opportunities within the field.2

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Biocompatible, Antifouling, and Thermosensitive Core−Shell Nanogels Synthesized by RAFT Aqueous Dispersion Polymerization

Cited by 213 publications

References 59 publications

Living Radical Polymerization by the RAFT Process – A Third Update

Living Radical Polymerization by the RAFT Process – A Third Update

Aqueous RAFT polymerization of N‐isopropylacrylamide‐mediated with hydrophilic macro‐RAFT agent: Homogeneous or heterogeneous polymerization?

Block copolymer synthesis by controlled/living radical polymerisation in heterogeneous systems

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