Biocompatible, bacteria-targeting resveratrol nanoparticles fabricated by Mannich molecular condensation for accelerating infected wound healing

Abstract

Excessive reactive oxygen species (ROS) and long-term inflammation can delay wound healing and cause tissue damage, while bacterial infection aggravates the wound environment further. It is impossible to resolve all...

In Vitro Anti-Inflammatory and Antioxidant Activities of pH-Responsive Resveratrol-Urocanic Acid Nano-Assemblies

“…However, RES-UA NPs exhibited increased ROS scavenging activity with decreasing pH values because RES-UA NPs could release higher amounts of RES from the NPs, as shown in Figure 3 . Additionally, RES-UA NPs displayed dose-dependent ROS scavenging activity at pH 5.0, which was associated with the amount of RES released from the NPs, consistent with the findings of previous studies [ 49 , 50 ].…”

Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

“…Resveratrol (Res), for example, has been encapsulated in NPs and functionalized by phenylboric acid to improve solubility and achieve better tissue distribution. [106] Owing to their anti-inflammatory and antioxidative activities, the in vivo results suggested that Res@NPs were capable of enhancing the formation of granulation tissues, re-epithelialization, and collagen deposition, thereby accelerating diabetic wound healing. [106] Moreover, inorganic compounds have been used in nanosystems with anti-inflammatory functions.…”

“…[106] Owing to their anti-inflammatory and antioxidative activities, the in vivo results suggested that Res@NPs were capable of enhancing the formation of granulation tissues, re-epithelialization, and collagen deposition, thereby accelerating diabetic wound healing. [106] Moreover, inorganic compounds have been used in nanosystems with anti-inflammatory functions. Prussian blue (PB), for example, features excellent anti-inflammatory and ROSscavenging properties (Figure 9).…”

“…[ 106 ] Owing to their anti‐inflammatory and antioxidative activities, the in vivo results suggested that Res@NPs were capable of enhancing the formation of granulation tissues, re‐epithelialization, and collagen deposition, thereby accelerating diabetic wound healing. [ 106 ]…”

Functional Nanoparticles Encapsulated in Resveratrol-Formaldehyde Resin for Cancer Therapy

“…Fortunately, resveratrol contains many ortho-H, which can be polymerized with formaldehyde in a straightforward and low-cost condensation reaction to produce NPs or enclose other functional NPs without compromising its bioactivities. 32 Inspired by the classical condensation polymerization between polyphenol and formaldehyde and the supramolecular interactions-involved and NPs-promoted deposition, a universal method for encapsulating functional NPs with resveratrolformaldehyde resin is demonstrated (Scheme 1). Ammonia is selected as the catalyst to facilitate the condensation and the stabilizer to prevent the aggregation of the as-prepared Res NPs via electrostatic repulsion.…”