Biocompatible, biodegradable and thermo-sensitive chitosan-g-poly (N-isopropylacrylamide) nanocarrier for curcumin drug delivery

Rejinold, N. Sanoj; Sreerekha, P.R.; Chennazhi, K.P.; Nair, Shanti V.; Jayakumar, R.

doi:10.1016/j.ijbiomac.2011.04.008

Cited by 153 publications

(63 citation statements)

References 30 publications

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“…Firstly, carboxyl-terminated PNIPAm is obtained by free radical polymerization in the presence of 3-mercaptopropionic acid as chain-transfer agent. Then, the homopolymer is grafted onto chitosan chain using a condensing agent such as EDC/ NHS [55,56].…”

Section: Synthesismentioning

confidence: 99%

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Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.

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Section: Synthesismentioning

confidence: 99%

“…The in vitro drug release was prominent at temperatures above LCST. The curcumin-loaded nanoparticles (NPs) showed specific toxicity on cancer cells and increased apoptosis on PC3 cells [55].…”

Section: Applicationsmentioning

confidence: 99%

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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show abstract

“…50 Similar observations were made with intravenous PLGA nanosuspensions, cuminosides conjugated nanoparticles, goldcuminosides nanoparticles, and a layer-by-layer self-assembly cuminosides formulation. [61][62][63][64][65] Rejinold et al demonstrated the biocompatibility nature of a thermosensitive cuminosides formulation by hemolysis assay.…”

Section: Pharmacokinetics and Bioavailabilitymentioning

confidence: 99%

A Review on Cuminosides Nanomedicine-: Pharmacognostic approach to Cancer therapeutics

Pradhan¹,

Tripathy²,

Pradhan³

et al. 2016

JYP

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“…In addition, it has been reported that the modified chitosan may be useful for both hydrophobic [88] and hydrophilic drug encapsulation [45] via a thermosensitive drug release mechanism. Also, nanoparticles produced with chitosan modified with PNIPAAm-COOH (chitosan-g-PNIPAAm) were developed for the delivery of curcumin [127]. The synthetic route for obtaining the modified chitosan is presented in Figure 7.14.…”

Section: Nanoparticles Produced With Chitosan-grafted Thermosensitivementioning

confidence: 99%

“…TPP was used as a crosslinker to obtain the nanoparticles. Interesting results were observed when using nanoparticles, namely, the specific toxicity of curcumin toward cancer cells [127].…”

Section: Nanoparticles Produced With Chitosan-grafted Thermosensitivementioning

confidence: 99%