Biocompatible chitosan based hydrogels for potential application in local tumour therapy

Olaru, Anda-Mihaela; Marin, Luminița; Morariu, Simona; Pricope, Gabriela; Pinteală, Mariana; Mititelu-Tarțău, Liliana

doi:10.1016/j.carbpol.2017.09.066

Cited by 84 publications

(48 citation statements)

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“…Chain conglutinating could be accomplished by physical interactions, for instance, the secondary forces (hydrogen and ionic bonds) or thermal‐induced entanglements . Polysaccharide hydrogels can be directly prepared from solutions via hydrogen bonding and linked networks from hydroxyl groups . Some types of solvents have been exploited to dissolve native polysaccharides, such as polar solvents, ionic liquids, and alkaline/urea …”

Section: Fabrication Of Polysaccharide‐based Hydrogelsmentioning

confidence: 99%

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Zhu

Mao

Cheng

et al. 2019

Adv Materials Inter

275

142

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Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.

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Section: Fabrication Of Polysaccharide‐based Hydrogelsmentioning

confidence: 99%

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Zhu

Mao

Cheng

et al. 2019

Adv Materials Inter

275

142

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“…Any matrix 2x2 given by (1) can be written as a linear combination with real coefficients involving two special matrices, namely unit matrix 1 and a matrix of null trace i (an involution) of the form: (2) Involution i has the properties that: (a) its square is multiple of 1 and (b) the fixed points of its homographic action are those of the matrix α . In equation (2) we have the freedom to choose a parameterization in which i square's to be right the unit matrix up to a sign.…”

Section: Theoretical Considerationsmentioning

confidence: 99%

“…Local delivery of drugs is quite a new and appealing pathway for the treatment of serious diseases such as acute inflammations, tumors, osteoarthritis, periodontitis, urinary tract or ear infections [1][2][3]. The main advantage of the local therapy over the systemic treatment resides in the targeted release of the drug, thus limiting the side effects on normal cells [4][5][6].…”

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confidence: 99%

Operational Procedures in the Theory of the Drug Release from Chitosan Hydrogels

Craciun¹,

Șerban²,

Crumpei³

et al. 2018

Mat.Plast.

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We build a theoretical model based on a generalization of harmonic applications of Misner-type. It results a sine-Gordon type fractal differential equation whose elliptical solutions can describe, through a convenient choice of fractal dynamic constants, various modes of drug release. Thus, the entire class of empirical models (Higuchi, Korsmeyer-Peppas, Peppas-Sahlin) describing the drug release processes can be dispensed with.

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“…At low temperatures (0-5ºC), PL/CS and GSH-PL/CS hydrogels had viscous behavior, whereas at higher temperatures (20 -40°C) the hydrogel had a solid-like behavior [62]. The gelling temperature (Tgel) indicated the temperature required to change the rheological property of the material, and is understood as when elastic modulus (G') becomes higher than loss modulus (G") during a temperature ramp [63]. This feature can be related to the presence of PL into the hydrogel matrix, and has attracted significant interest involving drug release applications and tissue engineering [64].…”

Section: Characterization Of Pl/cs and Gsh-pl/cs Hydrogelsmentioning

confidence: 99%

Biocompatible and Antibacterial Nitric Oxide-Releasing Pluronic F-127/Chitosan Hydrogel for Topical Applications

Pelegrino

Lima

Nascimento

et al. 2018

Preprint

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Nitric oxide (NO) is involved in physiological processes, including vasodilatation, wound healing and antibacterial activities. As NO is a free radical, designing drugs to generate therapeutic amounts of NO in controlled spatial and time manners is still a challenge. In this study, the NO donor S-nitrosoglutathione (GSNO) was incorporated into the thermoresponsive Pluronic F-127 (PL) - chitosan (CS) hydrogel, with an easy and economically feasible methodology. CS is a polysaccharide with known antimicrobial properties. Scanning electron microscopy, rheology and differential scanning calorimetry techniques were used for hydrogel characterization. The results demonstrated that the hydrogel has a smooth surface, thermoresponsive behavior and good mechanical stability. The kinetics of NO release and GSNO diffusion from GSNO-containing PL/CS hydrogel demonstrated a sustained NO/GSNO release, in concentrations suitable for biomedical applications. The GSNO-PL/CS hydrogel demonstrated a concentration-dependent toxicity to Vero cells, and antimicrobial activity to Pseudomonas aeruginosa (minimum inhibitory concentration and minimum bactericidal concentration values of 0.5 µg·mL-1 of hydrogel, which corresponds to 1 mmol·L-1 of GSNO). Interestingly, the concentration range in which the NO-releasing hydrogel demonstrated an antibacterial effect was not found to be toxic to the Vero mammalian cell. Thus, the GSNO-PL/CS hydrogel is a suitable biomaterial for topical NO delivery applications.

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Biocompatible chitosan based hydrogels for potential application in local tumour therapy

Cited by 84 publications

References 50 publications

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Operational Procedures in the Theory of the Drug Release from Chitosan Hydrogels

Biocompatible and Antibacterial Nitric Oxide-Releasing Pluronic F-127/Chitosan Hydrogel for Topical Applications

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