Biocompatible Degradable Hollow Nanoparticles from Curable Copolymers of Polylactic Acid for UV-Shielding Cosmetics

Abstract

Hollow polymeric nanoparticles have attracted vast attention as UV-shielding materials in personal care products due to their excellent light scattering characteristics and low density. In this work, a process for fabricating biocompatible/degradable poly­(lactic acid-co-glycidyl methacrylate), P­(LA-co-GMA), hollow nanoparticles via one-step phase inversion emulsification is examined, to gain insights into their formation mechanisms and optimization of the process parameters. The migration of poly­(vinyl alcohol) (PVA) (stabilizing agent) from the oil droplet to the oil/water interface while entangled with cross-linked P­(LA-co-GMA) chains and the fast evaporation rate of the chloroform solvent play an essential role in the hollow structure formation. Under optimum conditions, monodispersed hollow nanoparticles, with an average size of 500–700 nm and good colloidal stability, are obtained. The as-prepared hollow nanoparticles exhibit high UV shielding capabilities and low toxicity. The nanoparticles show high stability under UV exposure but can be completely degraded within 24 weeks under accelerated hydrolysis conditions. The materials have a high potential for use as environmental-friendly UV-shielding additives in cosmetic applications.

Fabrication of Sacha Inchi Oil-Loaded Microcapsules Employing Natural-Templated Lycopodium clavatum Spores and Their Pressure-Stimuli Release Behavior

“…As the microcapsule spores are intended for use as a protective shell for SIO from environmental factors, especially UV light in cosmetic products, the SIO-encapsulated spores (SIO@spore-0.75) were directly exposed to UV light. The sample was placed under a UV lamp (UVA and UVB) at a distance of 20 cm under accelerated conditions (UV intensity of 0.6 mW/cm 2 ). , The stability of the encapsulated microcapsule spores in avoiding possible breakage, which may affect the material’s practical use, was assessed. The shape and morphology of SIO@spore-0.75 were examined after UV treatment by SEM, as shown in Figure A.…”

“…The sample was placed under a UV lamp (UVA and UVB) at a distance of 20 cm under accelerated conditions (UV intensity of 0.6 mW/cm 2 ). 46 , 47 The stability of the encapsulated microcapsule spores in avoiding possible breakage, which may affect the material’s practical use, was assessed. The shape and morphology of SIO@spore-0.75 were examined after UV treatment by SEM, as shown in Figure 6 A.…”

Hollow Nanostructures of Ternary Ce1–xCuxO2 for Volatile Organic Compound Sensing

“…10,11 Similarly, hollow structures of polymers have also been used in various chemical industries. 12 To further add value to these types of particles, it is essential to stabilize more complex compositions and structures. In this study, we present the phase evolution in Ce 1−x Cu x O 2 hollow particles.…”

“…Therefore, mostly hollow particles of binary systems are being reported as the chemistry of such fabrication routes is simpler. For example, CuO hollow nanoparticles have been reported for catalysis and sensing applications. − Oxides of Mn, Co, Fe, Ni, etc., have led to high-performing electrode materials for Li-ion batteries and supercapacitors. , Similarly, hollow structures of polymers have also been used in various chemical industries …”

Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products

“…Hollow nanoparticles from PLA copolymers have been developed as UV-shielding materials in personal care products due to their excellent light scattering characteristics and low density [25,26]. Te material's UV shielding capabilities, toxicity, structural morphology, and formation mechanism were investigated.…”