Biocompatible electrospun CA and PHB wound dressings containing Alkannins &amp; Shikonins

Arampatzis, A; Giannakoula, Konstantina; Kontogiannopoulos, Konstantinos N.; Theodoridis, Konstantinos; Aggelidou, Eleni; Rat, Angélique; Kampasakali, Elli; Willems, Anne; Christofilos, D.; Κritis, Aristeidis; Assimopoulou, Andreana N.

doi:10.1055/s-0041-1736805

Cited by 1 publication

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“…Since then, there has been a rapid development in the structure, properties and applications of electrospinning. Nanofibrous membranes can support cell adhesion and angiogenesis [ 70 , 71 ]. Biocompatible poly(amino acid) nanofiber membranes can achieve effective hemostasis and repair of the wound [ 72 ].…”

Section: High-voltage Electrospinningmentioning

confidence: 99%

“…Nanofiber mats prepared from natural polymers and alkannin and shikonin (A/S) derivatives not only facilitate cell attachment and proliferation but also provide high antimicrobial activity [ 73 ]. It is worth mentioning that A/S derivatives promote wound healing and provide antibacterial and analgesic effects on ulcerated wounds [ 70 ]. Loading of A/S derivatives into nanofibers is ideal for topical and transdermal drug delivery [ 74 ].…”

Section: High-voltage Electrospinningmentioning

confidence: 99%

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Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

et al. 2022

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Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients. In the treatment of oral ulcers, nanofiber films can control the drug-release rate and enable long-term local administration. Compared to other drug-delivery methods, nanofiber films avoid the disadvantages of frequent administration and certain side effects. Electrospinning is a simple and effective method for preparing nanofiber films. Currently, electrospinning technology has made significant breakthroughs in energy-saving and large-scale production. This paper summarizes the polymers that enable oral mucosal adhesion and the active pharmaceutical ingredients used for oral ulcers. Moreover, the therapeutic effects of currently available electrospun nanofiber films on oral ulcers in animal experiments and clinical trials are investigated. In addition, solvent casting and cross-linking methods can be used in conjunction with electrospinning techniques. Based on the literature, more administration systems with different polymers and loading components can be inspired. These administration systems are expected to have synergistic effects and achieve better therapeutic effects. This not only provides new possibilities for drug-loaded nanofibers but also brings new hope for the treatment of oral ulcers.

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Section: High-voltage Electrospinningmentioning

confidence: 99%