Biocompatible Inorganic Nanoagent for Efficient Synergistic Tumor Treatment with Augmented Antitumor Immunity

Abstract

The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.202200897.Synergistic therapy for malignant tumors has been developed in the past. However, several disadvantages that are associated with the applied inorganic nanoagents cannot be avoided, including intrinsic systemic toxicity, immunosuppression, and low therapeutic efficiency. Herein, a biocompatible, multifunctional, inorganic nanoagent that simultaneously integrates chemodynamic, starvation, and photothermal therapies is developed. This nanoagent effectively converts endogenous H 2 O 2 into highly toxic hydroxyl radicals via the Fenton reaction. Self-reinforced cancer therapy is achieved via the scavenging of intracellular glutathione and glucose. The encapsulation of nanoagent by erythrocytes drastically reduces its immune recognition by macrophages. Thus, an augmented anti-tumor immune response is realized. Moreover, in contrast to traditional inorganic chemodynamic nanomaterials, the nanoagent has outstanding photothermal efficiency. Therefore, the present system exhibits an effective tumor therapeutic outcome. This work may facilitate a new pathway for the development of highly efficacious synergetic therapies.

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Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification

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Nanoceria-Based Artificial Nanozymes: Review of Materials and Applications

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“…(e) Schematic illustration of CuS@CeO 2 NPs as a tumor treatment platform. (f) In mice with CuS@CeO 2 NPs, tumor fluorescence disappeared after 24 h. (Panels a–d reprinted with permission from ref . Copyright 2022 Wiley-VCH GmbH.…”