Biocompatible ionic liquids and their applications in pharmaceutics

Moshikur, Rahman Md; Chowdhury, Raihan; Moniruzzaman, Muhammad; Goto, Masahiro

doi:10.1039/d0gc02387f

Cited by 171 publications

(166 citation statements)

References 198 publications

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“…During the last five years, researchers have reported promising results in developing pharmaceutically accepted O/W microemulsions as delivery systems of lipophilic drugs for oral or topical administration [ 1 , 2 , 50 ]. Such biocompatible microemulsion formulations could be extremely effective in the selective delivery of chemotherapeutics to cancer cells, a major issue in cancer research worldwide [ 2 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

“…During the last decade, a lot of efforts have focused on the design and development of novel drug delivery carriers to address drawbacks such as low solubility, stability and bioavailability in pharmaceutics and medicine [ 1 , 2 , 3 ]. A growing number of studies refer to the development of drug nanocarriers based on soft nanosized systems.…”

Section: Introductionmentioning

confidence: 99%

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Biological Evaluation of Oil-in-Water Microemulsions as Carriers of Benzothiophene Analogues for Dermal Applications

et al. 2021

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During the last decade, many studies have been reported on the design and formulation of novel drug delivery systems proposed for dermal or transdermal administration. The efforts focus on the development of biocompatible nanodispersions that can be delivered to the skin and treat severe skin disorders, including cancer. In this context, oil-in-water (O/W) microemulsions have been developed to encapsulate and deliver lipophilic bioactive molecules for dermal application. An O/W biocompatible microemulsion composed of PBS buffer, Tween 80, and triacetin was assessed for its efficacy as a drug carrier of DPS-2, a lead compound, initially designed in-house to inhibit BRAFV600E oncogenic kinase. The system was evaluated through both in vitro and ex vivo approaches. The cytotoxic effect, in the presence and absence of DPS-2, was examined through the thiazolyl blue tetrazolium bromide (MTT) cell proliferation assay using various cell lines. Further investigation through Western blotting revealed that cells died of necrosis. Porcine ear skin was used as a skin model to evaluate the degree of permeation of DPS-2 through skin and assess its retention. Through the ex vivo experiments, it was clarified that encapsulated DPS-2 was distributed within the full thickness of the stratum corneum (SC) and had a high affinity to hair follicles.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biological Evaluation of Oil-in-Water Microemulsions as Carriers of Benzothiophene Analogues for Dermal Applications

et al. 2021

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“…The advantages of using ILs in the pharmaceutical industry are associated with their use as solvents to solubilize poorly soluble drugs, thus improving delivery, and with their potential in reducing typical problems affecting solid-state drugs such as polymorphism and bioavailability (Md Moshikur et al 2020 ). The use of biocompatible ILs such as ChAAILs, in this context, has obvious advantages because they allow one to circumvent the toxicity issue of other ILs.…”

Section: Toxicity and Biodegradabilitymentioning

confidence: 99%

Cholinium amino acid-based ionic liquids

Donne

Bodo

2021

Biophys Rev

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Boosted by the simplicity of their synthesis and low toxicity, cholinium and amino acid-based ionic liquids have attracted the attention of researchers in many different fields ranging from computational chemistry to electrochemistry and medicine. Among the uncountable IL variations, these substances occupy a space on their own due to their exceptional biocompatibility that stems from being entirely made by metabolic molecular components. These substances have undergone a rather intensive research activity because of the possibility of using them as greener replacements for traditional ionic liquids. We present here a short review in the attempt to provide a compendium of the state-of-the-art scientific research about this special class of ionic liquids based on the combination of amino acid anions and cholinium cations.

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“…The latter strategy is what we want to highlight in this review. Irrespective, many of them are used in pharmaceutical products [ 12 ].…”

Section: Biocompatible Rms Formulated With Sailsmentioning

confidence: 99%

“…The conventional non-polar solvents used are mainly toxic and/or non-environmentally friendly. One strategy to overcome this is the use of the proper ionic liquids (ILs) [ 12 , 13 ]. ILs are compounds that are composed entirely of ions and, because of the large size of the anion or cation or both, the melting point is low in comparison with traditional salts.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Solvents and Ionic Liquid-Based Surfactants as Sustainable Components to Formulate Environmentally Friendly Organized Systems

et al. 2021

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In this review, we deal with the formation and application of biocompatible water-in-oil microemulsions commonly known as reverse micelles (RMs). These RMs are extremely important to facilitate the dissolution of hydrophilic and hydrophobic compounds for biocompatibility in applications in drug delivery, food science, and nanomedicine. The combination of two wisely chosen types of compounds such as biocompatible non-polar solvents and ionic liquids (ILs) with amphiphilic character (surface-active ionic liquids, SAILs) can be used to generate organized systems that perfectly align with the Green Chemistry concepts. Thus, we describe the current state of SAILs (protic and aprotic) to prepare RMs using non-polar but safe solvents such as esters derived from fatty acids, among others. Moreover, the use of the biocompatible solvents as the external phase in RMs and microemulsions/nanoemulsions with the other commonly used biocompatible surfactants is detailed showing the diversity of preparations and important applications. As shown by multiple examples, the properties of the RMs can be modified by changes in the type of surfactant and/or external solvents but a key fact to note is that all these modifications generate novel systems with dissimilar properties. These interesting properties cannot be anticipated or extrapolated, and deep analysis is always required. Finally, the works presented provide valuable information about the use of biocompatible RMs, making them a green and promising alternative toward efficient and sustainable chemistry.

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Biocompatible ionic liquids and their applications in pharmaceutics

Abstract: Ionic liquids (ILs) have been used as solvents or materials, or both, in many applications, including pharmaceutics and medicine due to their exceptional properties consisting of the combination of “green”...

Cited by 171 publications

References 198 publications

Biological Evaluation of Oil-in-Water Microemulsions as Carriers of Benzothiophene Analogues for Dermal Applications

Biological Evaluation of Oil-in-Water Microemulsions as Carriers of Benzothiophene Analogues for Dermal Applications

Cholinium amino acid-based ionic liquids

Biocompatible Solvents and Ionic Liquid-Based Surfactants as Sustainable Components to Formulate Environmentally Friendly Organized Systems

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