Biocompatible, pH-responsive, and biodegradable polyurethanes as smart anti-cancer drug delivery carriers

To reduce cost and increase environmental friendliness, waterborne polyurethane (WPU) is a tempting choice in the field of green chemistry. Biodegradable WPU was synthesized using lysine as an internal emulsifier. WPU was further modified using methylate methacrylate (MMA) as an acrylic monomer. Unsaturated pre‐PU was synthesized by using unsaturated end‐capping agent 2‐hydroxyethyl methacrylate and further extended by MMA to form acrylate modified WPU. A permanent covalent linkage was established between WPU and PMMA as confirmed by FTIR spectroscopy. The focus of this research work was to study the dependence of drug delivery, mechanical, thermal, surface, and structural properties of WPU, on the MMA repeating unit content (10%–40%). For drug release studies mitomycin c was taken as a model anticancer drug. Furthermore, these materials were subjected to in vitro and in vivo cytotoxicity evaluation, which shows that synthesized acrylate modified WPU are biocompatible. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47253.

Section: Resultsmentioning

confidence: 90%

Section: Chemical Resistancementioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

“…For in vivo tissue histopathology, balb c mice were used and PUA were subcutaneously implanted. The detailed procedure has been given in our previous work …”

Section: Methodsmentioning

confidence: 99%

Section: Mtt Assay and In Vivo Tissue Histopathologymentioning

confidence: 99%

See 3 more Smart Citations

Modulating the burst drug release effect of waterborne polyurethane matrix by modifying with polymethylmethacrylate

Bahadur

Saeed

Shoaib

et al. 2018

pH and magnetic field responsive protein‐inorganic nanohybrid conjugated with biotin: A biocompatible carrier system targeting lung cancer cells

Purushothaman

2020

Multi-stimuli responsive carrier systems, specifically targeting tumor cells are of high significance to improve the efficacy of cancer chemotherapy. In the present study, we have developed, characterized, and biologically evaluated magnetic casein-calcium ferrite hybrid biopolymeric carrier conjugated with biotin for targeted delivery of cinnamaldehyde to lung carcinoma. The dual stimuli-responsive carrier was successfully synthesized with small size, good stability, and high drug encapsulation efficiency. Natural drug cinnamaldehyde was encapsulated in the hybrid carrier, on which biotin was conjugated to facilitate selective cellular uptake. The prepared drug-carrier system exhibited pH-responsive drug release behavior with a higher release rate under acidic conditions, which can be effectively applied in targeted cancer chemotherapy. The superparamagnetic nature of calcium ferrite enabled magnetically-modulated drug delivery with faster drug release, reaching 85.5% within 4 h, in response to magnetic field stimulus. Kinetic modeling of drug release projected the diffusion-controlled release mechanism. Cell viability assay performed on L929 fibroblast and A549 lung cancer cells verified the biocompatibility and cytotoxicity of the developed formulation, respectively. The nanohybrid carrier significantly increased the anticancer potential of cinnamaldehyde with an 18-fold reduction in the IC 50 value, signifying the biotinfunctionalized protein-inorganic nanohybrid as an efficient multifunctional platform for targeted drug delivery.

pH‐responsive polyurethane‐acrylate from palm olein and sunflower oil: Sustainable synthesis, enhanced lovastatin solubility, and potential drug carrier for targeted delivery

Tan,

Lee,

Pichika

et al. 2024

A pH responsive non‐isocyanate polyurethane‐acrylate (NIPUA) is synthesized through utilizing palm olein and sunflower oil as feedstock. The unsaturated acyl chains of both vegetable oils are converted into epoxy rings through epoxidation and subjected to carbonation with binary catalytic system under a solventless and mild condition to produce the cyclic carbonates. The cyclic carbonates were reacted with 1,4‐butanediamine and itaconic acid to produce the NIPUA. The intermediates and product were characterized by FTIR spectroscopy, NMR spectroscopy and gel permeation chromatography. The NIPUA was incorporated with poly(vinyl pyrrolidone) (PVP) to form a polymer carrier system loaded with a hydrophobic model drug, lovastatin (LOV). All NIPUA/PVP preformulations demonstrated pH responsiveness, with 1 to 2‐folds enhanced solubility at pH 7.4 compared to pH 2.0. NIPUA/PVP exhibited solubility enhancer effect by significantly enhanced solubility (2–4 times) compared to pure LOV, LOV‐loaded PVP, and Medostatin tablets at both pH levels. LOV‐loaded NIPUA/PVP exhibited lower enthalpy energy in DSC thermogram than LOV‐loaded PVP, indicating disruption of LOV's crystalline structure. In MTT assay, IC50 values were 30.76 μg mL−1 for pure LOV and 273.53 μg mL−1 for NIPUA/PVP, demonstrating the potential of NIPUA as an environmentally friendly, pH responsive drug carrier for controlled release of poorly water‐soluble drugs.