Biocompatible waterborne polyurethane-urea elastomer as intelligent anticancer drug release matrix: A sustained drug release study

Bahadur, Ali; Saeed, Aamer; Iqbal, Shahid; Shoaib, Muhammad; Rahman, Muhammad Saif Ur; Bashir, Muhammad Imran; Asghar, M.; Ali, Muhammad Asif; Mahmood, Tahir

doi:10.1016/j.reactfunctpolym.2017.08.001

Cited by 43 publications

(25 citation statements)

References 48 publications

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“…The addition of CNCs reduced the crystallinity of HS and T m,HS reduced to 158.2 C for HS1.0 because CNCs created disturbing at HS hydrogen bonding. 50,54 The bond strength of Si O bond is higher than C C bond 40 ; therefore, degradation temperature of PDMS is significantly higher than of polymer containing C C bond. In this case, the polyol chains could not prevent the chain regularity in the HS and consequently, the HS chains could be ordered in the crystalline cells.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of in vitro cytotoxicity and properties of polydimethylsiloxane‐based polyurethane/crystalline nanocellulose bionanocomposites

Khadivi

Salami‐Kalajahi

Roghani‐Mamaqani

2019

J Biomedical Materials Res

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Polydimethylsiloxane‐based polyurethane (PU)/crystalline nanocellulose (CNC) bionanocomposites were produced via in situ prepolymer approach. Also, hexamethylene diisocyanate as aliphatic diisocyanate monomer and 1,4‐butanediol as aliphatic chain extender were used. CNC was incorporated into PU matrix to prepare different PU/CNC bionanocomposites. Effect of CNC content on the properties of the bionanocomposites such as thermal, thermophysical, microstructure, and in vitro cytotoxicity was investigated. According to the results, incorporating CNCs into PU matrix significantly affected the hydrogen bonding between different microstructures of matrix. Adding different amounts of CNCs affected the thermal and thermophysical properties of bionanocomposites. Also, higher amounts of CNCs resulted in lower crystallization of hard segment. Neat PU matrix showed a moderate cytotoxicity behavior against human fibroblast cells. However, incorporating CNCs significantly improved the cytotoxicity behavior of bionanocomposites where by addition of 2 wt % of CNCs, cell viability increased to 90–100%. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1771–1778, 2019.

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Section: Resultsmentioning

confidence: 99%

Evaluation of in vitro cytotoxicity and properties of polydimethylsiloxane‐based polyurethane/crystalline nanocellulose bionanocomposites

Khadivi

Salami‐Kalajahi

Roghani‐Mamaqani

2019

J Biomedical Materials Res

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“…Average of the triplicate experiment was reported. Detail method for drug loading and release studies has been given in our previous work …”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, biodegradable PU is generally used as implants for tissue regeneration and drug delivery . Although non‐degradable PUs can also be used for drug delivery, they are to be removed from the body once their function is accomplished . Therefore, the use of biodegradable PU is the viable solution which can be used in the form of nanocapsules, pellets, micelles, nanoparticles, microspheres, foams, films, and scaffolds .…”

Section: Introductionmentioning

confidence: 99%

“…The other factors such as temperature, enzymes, and pH also influence the drug release kinetics . But the main drawbacks associated with the PUs is that most of these are solvent‐based systems and pose a threat to the environment . Furthermore, generally biodegradable PUs has greater swelling, and higher drug release at the very start, causing a burst release effect .…”

Section: Introductionmentioning

confidence: 99%

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Modulating the burst drug release effect of waterborne polyurethane matrix by modifying with polymethylmethacrylate

Bahadur

Saeed

Shoaib

et al. 2018

J of Applied Polymer Sci

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To reduce cost and increase environmental friendliness, waterborne polyurethane (WPU) is a tempting choice in the field of green chemistry. Biodegradable WPU was synthesized using lysine as an internal emulsifier. WPU was further modified using methylate methacrylate (MMA) as an acrylic monomer. Unsaturated pre‐PU was synthesized by using unsaturated end‐capping agent 2‐hydroxyethyl methacrylate and further extended by MMA to form acrylate modified WPU. A permanent covalent linkage was established between WPU and PMMA as confirmed by FTIR spectroscopy. The focus of this research work was to study the dependence of drug delivery, mechanical, thermal, surface, and structural properties of WPU, on the MMA repeating unit content (10%–40%). For drug release studies mitomycin c was taken as a model anticancer drug. Furthermore, these materials were subjected to in vitro and in vivo cytotoxicity evaluation, which shows that synthesized acrylate modified WPU are biocompatible. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47253.

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“…In order to restrain thermal quenching of triplet excitons, luminogens have to be prepared as crystals or incorporated in polymers . Waterborne polyurethane (WPU) is a kind of polymer with tunable soft and hard segments, which has a satisfactory film‐forming property and has been widely used as coatings, leathers, textiles, and matrices for functional materials . Compared to terminal‐functional polymers, like polylactides (PLAs), luminogens covalently incorporated in WPU main chain via polyaddition reaction suffer less aggregation of luminogens in that luminogens in the main chains have smaller free volumes.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Thermally Activated Delayed Fluorescence in Waterborne Polyurethanes via Charge‐Transfer Effect

Wang

et al. 2019

Chemistry An Asian Journal

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Here, we designed several waterborne polyurethanes (WPUs) with efficient thermally activated delayed fluorescence (TADF) via serving charge‐transfer (CT) states as a mediate bridge between singlet and triplet states to boost reverse intersystem crossing (RISC). By tuning substituents of diphenyl sulfone (DS), we found that O,O′‐ and S,S′‐substituted DS covalently incorporated in WPUs solely show typical fluorescence emission with lifetimes in the nanosecond range. Interestingly, TADF appears by replacing the substituent with the nitrogen atom, of which lifetimes are up to ≈10 microseconds and ≈1 millisecond in air and vacuum, respectively, even though the energy gap between singlet and triplet states (ΔEST) is still large for generating TADF. To explain this phenomenon, an energy level mode based on CT states and an 3(n‐π*) receiver state was proposed. By the rational modulation of CT states, it is possible to tune the ΔEST to render TADF‐based materials suitable for versatile applications.

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Biocompatible waterborne polyurethane-urea elastomer as intelligent anticancer drug release matrix: A sustained drug release study

Cited by 43 publications

References 48 publications

Evaluation of in vitro cytotoxicity and properties of polydimethylsiloxane‐based polyurethane/crystalline nanocellulose bionanocomposites

Evaluation of in vitro cytotoxicity and properties of polydimethylsiloxane‐based polyurethane/crystalline nanocellulose bionanocomposites

Modulating the burst drug release effect of waterborne polyurethane matrix by modifying with polymethylmethacrylate

Modulation of Thermally Activated Delayed Fluorescence in Waterborne Polyurethanes via Charge‐Transfer Effect

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