Biocomposite films based on chitosan and cerium oxide nanoparticles with promising regenerative potential

Петрова, В. А.; Dubashynskaya, Natallia V.; Гофман, И. В.; Головкин, А. С.; Mishanin, Alexander I.; Aquino, Arthur D.; Mukhametdinova, Daria; Nikolaeva, Alexandra L.; Иванькова, Е. М.; Баранчиков, А. Е.; Yakimansky, А. V.; Иванов, В. К.; Skorik, Yury A.

doi:10.1016/j.ijbiomac.2022.12.305

Cited by 8 publications

(10 citation statements)

References 38 publications

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“…Moreover, changes in the 1090 cm −1 and 934 cm −1 regions would result in vibrations in the CC, COC, and OH groups in the CRG structure. There will also be demonstrations of the formation of hydrogen bonds between CeO 2 NPs and CRG, as well as GA crosslinking [ 43 ]. In accordance with previous studies, the band at 848 cm −1 is associated with a metal–oxygen bond.…”

Section: Resultsmentioning

confidence: 99%

Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO2 NPs) for Hemostatic Applications

Alizadeh,

Dezvare,

Kamyab

et al. 2023

Biomimetics

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In this study, a novel absorbable hemostatic agent was developed using carrageenan (CRG) as a natural polymer and cerium oxide nanoparticles (CeO2 NPs). CRG-CeO2-0.5 and CRG-CeO2-1 composites were prepared by compositing CeO2 to CRG + CeO2 at a weight ratio of 0.5:100 and 1:100, respectively. The physicochemical and structural properties of these compounds were studied and compared with pristine CRG. Upon incorporation of CeO2 nanoparticles into the CRG matrix, significant reductions in hydrogel degradation were observed. In addition, it was noted that CRG-CeO2 exhibited better antibacterial and hemostatic properties than CRG hydrogel without CeO2 NPs. The biocompatibility of the materials was tested using the NIH 3T3 cell line, and all samples were found to be nontoxic. Particularly, CRG-CeO2-1 demonstrated superior hemostatic effects, biocompatibility, and a lower degradation rate since more CeO2 NPs were present in the CRG matrix. Therefore, CRG-CeO2-1 has the potential to be used as a hemostatic agent and wound dressing.

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Section: Resultsmentioning

confidence: 99%

Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO2 NPs) for Hemostatic Applications

Alizadeh,

Dezvare,

Kamyab

et al. 2023

Biomimetics

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“…CS-stabilized CeONPs were prepared according to the procedure described elsewhere [ 32 ]. CS-coated CeONPs had a ζ-potential of +20.3 mV and a D h of 244 nm.…”

Section: Methodsmentioning

confidence: 99%

“…In our previous studies, we obtained BC-based composites by impregnating the squeezed BC gel film with polysaccharide solutions containing citrate-stabilized ceria nanoparticles (CeONPs) [ 12 ] and CS-based composites containing CeONPs [ 32 ]. These studies have demonstrated the beneficial effects of CeONPs on the culture of human mesenchymal stem cells (MSCs), as evidenced by changes in stem cell behavior such as their migration, proliferation, and differentiation [ 12 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Composites with Bacterial Cellulose Nanofibers Doped with Nanosized Cerium Oxide: Characterization and Cytocompatibility Evaluation

Петрова

Gofman

Dubashynskaya

et al. 2023

IJMS

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In this work, new composite films were prepared by incorporating the disintegrated bacterial cellulose (BCd) nanofibers and cerium oxide nanoparticles into chitosan (CS) matrices. The influence of the amount of nanofillers on the structure and properties of the polymer composites and the specific features of the intermolecular interactions in the materials were determined. An increase in film stiffness was observed as a result of reinforcing the CS matrix with BCd nanofibers: the Young’s modulus increased from 4.55 to 6.3 GPa with the introduction of 5% BCd. A further increase in Young’s modulus of 6.7 GPa and a significant increase in film strength (22% increase in yield stress compared to the CS film) were observed when the BCd concentration was increased to 20%. The amount of nanosized ceria affected the structure of the composite, followed by a change in the hydrophilic properties and texture of the composite films. Increasing the amount of nanoceria to 8% significantly improved the biocompatibility of the films and their adhesion to the culture of mesenchymal stem cells. The obtained nanocomposite films combine a number of favorable properties (good mechanical strength in dry and swollen states, improved biocompatibility in relation to the culture of mesenchymal stem cells), which allows us to recommend them for use as a matrix material for the culture of mesenchymal stem cells and wound dressings.

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“…Previously, in a series of works on composites containing CeONPs, we have established the effect of CeONPs on the physicochemical properties of polymer composites, as well as the effect of the polymer component on the activity of CeONPs against mesenchymal stem cells. The optimal compositions for obtaining polymer composites with improved bioactivity were also determined [14][15][16]. The introduction of CeONPs was found to alter the structural organization of CS films [14] and CS-bacterial cellulose composites [15,16], affecting their morphology and increasing swelling.…”

Section: Introductionmentioning

confidence: 99%

“…The optimal compositions for obtaining polymer composites with improved bioactivity were also determined [14][15][16]. The introduction of CeONPs was found to alter the structural organization of CS films [14] and CS-bacterial cellulose composites [15,16], affecting their morphology and increasing swelling. The nanocomposites showed increased Young's modulus and good strength properties, indicating strong intermolecular interactions between matrix and nanofiller.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Composites of Chitosan with Cerium Oxide Nanoparticles for Wound Healing Applications: Characterization and Biocompatibility Evaluation In Vitro and In Vivo

Petrova,

Poshina,

Golovkin

et al. 2024

Polymers

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Cerium oxide nanoparticles (CeONPs), as part of tissue regeneration matrices, can protect cells from reactive oxygen species and oxidative stress. In addition, they can influence the properties of the scaffold, including its electrospinnability and mechanical strength. In this work, we prepared electrospun fiber mats from a chitosan and polyethylene oxide blend (CS-PEO) with the addition of ceria nanoparticles (CS-PEO-CeONP). The addition of CeONPs resulted in a smaller fiber diameter and higher swelling compared to CS-PEO fiber mats. CeONP-modified fiber mats also had a higher Young’s modulus due to the reinforcing effect of the nanoparticles. Both mats had comparable adhesion and cytocompatibility to mesenchymal stem cells, which had a more rounded morphology on CS-PEO-CeONP compared to elongated cells on the CS-PEO mats. Biocompatibility in an in vivo rat model showed no acute toxicity, no septic or allergic inflammation, and no rough scar tissue formation. The degradation of both mats passed the stage of matrix swelling. CS-PEO-CeONP showed significantly slower biodegradation, with most of the matrix remaining in the tissue after 90 days. The reactive inflammation was aseptic in nature with the involvement of multinucleated foreign-body type giant cells and was significantly reduced by day 90. CeONPs induced the formation of the implant’s connective tissue capsule. Thus, the introduction of CeONPs influenced the physicochemical properties and biological activity of CS-PEO nanofiber mats.

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Biocomposite films based on chitosan and cerium oxide nanoparticles with promising regenerative potential

Cited by 8 publications

References 38 publications

Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO2 NPs) for Hemostatic Applications

Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO2 NPs) for Hemostatic Applications

Chitosan Composites with Bacterial Cellulose Nanofibers Doped with Nanosized Cerium Oxide: Characterization and Cytocompatibility Evaluation

Electrospun Composites of Chitosan with Cerium Oxide Nanoparticles for Wound Healing Applications: Characterization and Biocompatibility Evaluation In Vitro and In Vivo

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