Biodegradable anionic acrylic resin based hollow microspheres of moderately water soluble drug Rosiglitazone Maleate: preparation and<i>in vitro</i>characterization

Rane, Bhushan R.; Gujarathi, Nayan A.; Patel, Jayvadan

doi:10.3109/03639045.2011.653811

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…The microspheres were then well packed and leveled. The density was calculated as the following equation:

ρ = \frac{m}{V}

where V is the volume of crucible.…”

Section: Methodsmentioning

confidence: 99%

Fabrication and structural regulation of PLLA porous microspheres via phase inversion emulsion and thermally induced phase separation techniques

Nie

et al. 2017

J of Applied Polymer Sci

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In this work, a facile, scalable technique was developed to produce biodegradable porous microspheres by combining an oil‐in‐oil (O/O) surfactant‐free phase inversion emulsion technique with thermally induced phase separation (TIPS) method. The effects of PLLA concentration, stirring speed, macromolecule weight, and organic solvents on the size and microstructure of microspheres were investigated by scanning electron microscopy (SEM). The results revealed a highly porous structured microsphere with controllable sizes and morphologies by tuning the synthesis conditions. The typical resulting PLLA microspheres consist of nanoscale topographic structured surface and highly microporous interior. The coarse nanotopography and microcellular inner structure lead to a high drug loading capacity up to 60% for the PLLA microspheres from THF. The cumulative release percentage of the ibuprofen could reach 80% for drug‐loaded microspheres with different microstructures. The fabricated PLLA microspheres would have potential applications in the field of drug delivery and tissue engineering. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44885.

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“…The microspheres were then well packed and leveled. The density was calculated as the following equation:

ρ = \frac{m}{V}

where V is the volume of crucible.…”

Section: Methodsmentioning

confidence: 99%

Fabrication and structural regulation of PLLA porous microspheres via phase inversion emulsion and thermally induced phase separation techniques

Nie

et al. 2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…The obtained blood samples were taken in heparinized tube and are subjected to centrifugation; the resulted plasma fraction was transferred by micropipette into the Eppendorf tubes to be frozen immediately at-20 °C until further analysis. WinNonlin version 3.0 software (P Corporation, USA) was used for the measurement of the concentration of drug in plasma overtime [21]. Analysis was done by using non-compartmental method, data were desired from dose administered and statistical moments of the plasma concentration-time profile All the plasma drug concentration were computed based on trapezoid area calculation.…”

Section: Pharmacokinetic Studymentioning

confidence: 99%

Eplerenone Floating Microspheres: Radiographic and Pharmacokinetic Studies in Rabbits

BOORUGU,

G.V.

2024

Int J App Pharm

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Objective: The objective of the present investigation was to evaluate gastro-retentive performance and pharmacokinetic parameters of Eplerenone-optimized floating microspheres compared with formulated floating tablets. Methods: Microsphere contains antihypertensive drug Eplerenone as a core material encapsulated with the polymeric membrane for sustained drug release were prepared by solvent diffusion-evaporation technique. The prepared microspheres were evaluated for qualitative and quantitative parameters. The optimized formulation showed favorable in vitro floating and drug release profile. The gamma scintigraphy of the formulation was carried out in rabbit in order to determine the floating ability of the final formulation with barium sulfate. Prolonged gastric residence time of over 12 h was achieved in all the animals. Eplerenone-loaded optimized formulation was orally administered to rabbit and blood samples were used to determine pharmacokinetic parameter by using WinNonlin software 3.0 version. Results: Eplerenone floating microsphere, which are compared with pharmacokinetic parameters of the Floating tablet showed improved parameters of Cmax; similarly, time to reach peak plasma concentration (t-max) for Eplerenone Floating microspheres was 4 times increased against Floating tablet formulation. The area under the curve (AUC) for formulated floating tablet was found to be 9.69 µg/ml, whereas for floating microspheres it was 16.28 µg/ml, for formulated floated tablet absorption rate constant Ka was 1.61 h, elimination rate constant was 0.112 h and elimination half-life 6.2 h. The comparison of these data undoubtedly shows that the Cmax was not much valid, but AUC was increased to about 1.68 times in case of floating microspheres, absorption rate constant was found to be decrease 3.22 times when related to the floating microspheres, whereas Ke was found to be decrease 2.11 times when equated to floating microspheres, elimination half-life was increased by almost about two times. Conclusion: Eplerenone floating microsphere, which are compared with pharmacokinetic parameters of the floating tablets showed enhanced parameters of the formulated due to floating nature of the present designed formulation.

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“…They provided evidence that a modification of external aqueous phase with salt (CaCl2 and NaCl) improved the drug entrapment efficiency for moderately soluble drug by 45-50% as a result of salting out effect. Predominantly, the release mechanism for formulations was diffusion controlled and followed the first order kinetics [Rane et al, 2012]. …”

Section: Hollow Microspheres / Microballoonsmentioning

confidence: 99%

Novel Drug Delivery Systems for Modulation of Gastrointestinal Transit Time

Javadzadeh¹,

Hamedeyazdan²

2012

Recent Advances in Novel Drug Carrier Systems

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Biodegradable anionic acrylic resin based hollow microspheres of moderately water soluble drug Rosiglitazone Maleate: preparation andin vitrocharacterization

Cited by 3 publications

References 18 publications

Fabrication and structural regulation of PLLA porous microspheres via phase inversion emulsion and thermally induced phase separation techniques

Fabrication and structural regulation of PLLA porous microspheres via phase inversion emulsion and thermally induced phase separation techniques

Eplerenone Floating Microspheres: Radiographic and Pharmacokinetic Studies in Rabbits

Novel Drug Delivery Systems for Modulation of Gastrointestinal Transit Time

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