Biodegradable/biocompatible coated metal implants for orthopedic applications

Abstract

Biocompatible metals have been suggested as revolutionary biomaterials for bone-grafting therapies. Although metals and their alloys are widely and successfully used in producing biomedical implants due to their good mechanical properties and corrosion resistance, they have a lack in bioactivity. Therefore coating of the metal surface with calcium phosphates (CaP) is a benign way to achieve well bioactivity and get controlled corrosion properties. The biocompatibility and bioactivity calcium phosphates (CaP) in bone growth were guided them to biomedical treatment of bone defects and fractures. Many techniques have been used for fabrication of CaP coatings on metal substrates such as magnesium and titanium. The present review will focus on the synthesis of CaP and their relative forms using different techniques especially electrochemical techniques. The latter has always been known of its unique way of optimizing the process parameters that led to a control in the structure and characteristics of the produced materials.

Novel Bio-functional Magnesium Coating on Porous Ti6Al4V Orthopaedic Implants: In vitro and In vivo Study

“…With exposure to high chloride concentrations such as in a physiological environment, Mg(OH) 2 reacts with chloride ions to produce MgCl 2 , which is highly soluble53. This promotes the rapid dissolution of the Mg coating, with the subsequent production of hydrogen gas and hydroxide ions.…”

Phosphorus Science-Oriented Design and Synthesis of Multifunctional Nanomaterials for Biomedical Applications

“…98,99 These metal phosphate nanomaterials also present excellent biocompatibility and biodegradability. For example, CaPs are widely used in the field of bone regeneration due to their superior biocompatibility 100 and their unique role in human bone. Compared with other types nanomaterial, metal phosphate nanomaterials are mainly generated via the hydrothermal method, 101 which is relatively simple.…”

Bio-Functional Design, Application and Trends in Metallic Biomaterials

“…Thus, fractured bone fixtures stimulate BMs to become a huge potential market in orthopedic applications [ 142 ]. Many Mg-based alloys such as ZEK 100, LAE442 and MgCa0.8 have been fabricated into screws for animal models and clinical trials [ 13 , 85 , 143 , 144 ]. A twelve months in vivo animal model confirmed that the Mg-based alloys showed positive osteogenetic effects after implantation.…”