Biodegradable blends of high molecular weight poly(ethylene oxide) with poly(3-hydroxypropionic acid) and poly(3-hydroxybutyric acid): a miscibility study by DSC, DMTA and NMR spectroscopy

He, Yong; Asakawa, Naoki; Inoue, Yoshio

doi:10.1002/1097-0126(200006)49:6<609::aid-pi426>3.0.co;2-6

Cited by 31 publications

(24 citation statements)

References 30 publications

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“…Solvents used to fabricate blends have a significant effect on their miscibility and morphology as reported extensively in the recent literatures [33][34][35][36]. For example, Wu et al [33] characterized the poly(vinyl acetate)-poly(ethylene oxide) (PVAc-PEO) blends and for their study they used chloroform and benzene as solvents.…”

Section: Discussionmentioning

confidence: 99%

Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid)

et al. 2008

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Previously we demonstrated the ability of ethyl glycinato substituted polyphosphazenes to neutralize the acidic degradation products and control the degradation rate of poly(lactic acid-glycolic acid) by blending. In this study, blends of high strength poly[(50% ethyl alanato) (50% p-phenyl phenoxy) phosphazene] (PNEA 50 PhPh 50 ) and 85:15 poly(lactic acid-glycolic acid) (PLAGA) were prepared using a mutual solvent approach. Three different solvents, methylene chloride (MC), chloroform (CF) and tetrahydrofuran (THF) were studied to investigate solvent effects on blend miscibility. Three different blends were then fabricated at various weight ratios namely 25:75 (BLEND25), 50:50 (BLEND50), and 75:25 (BLEND75) using THF as the mutual solvent. The miscibility of the blends was evaluated by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Among these, BLEND25 was miscible while BLEND50 and BLEND75 were partially miscible. Furthermore, BLEND25 formed apatite layers on its surface as evidenced in a biomimetic study performed. These novel blends showed cell adhesion and proliferation comparable to PLAGA. However, the PNEA 50 PhPh 50 component in the blends was able to increase the phenotypic expression and mineralized matrix synthesis of the primary rat osteoblasts (PRO) in vitro. Blends of high strength poly[(50% ethyl alanato) (50% p-phenyl phenoxy) phosphazene] (PNEA 50 PhPh 50 ) and 85:15 poly(lactic acid-glycolic acid) (PLAGA) are promising biomaterials for a variety of musculoskeletal applications.

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Section: Discussionmentioning

confidence: 99%

Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid)

et al. 2008

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“…[13][14][15][16] Therefore, is has been the aim of some researchers to prepare PHB/ polymer blends to overcome some of these weaknesses. Previous attempts to obtain improved biodegradable PHB materials have been performed by blending PHB with poly(ethylene oxide) (PEO), [17][18][19][20] poly(L-lactide), poly(L-lactic acid) (PLLA), poly(D-lactide), PDLA, [21] or poly(e-caprolactone) (PCL). [15,22,23] PCL is a synthetic semicrystalline linear polyester that has also proven to be biocompatible and biodegradable; [24] it can be degraded by some enzymes from several microorganisms.…”

Section: Full Papermentioning

confidence: 99%

Crystallization, Morphology, and Enzymatic Degradation of Polyhydroxybutyrate/Polycaprolactone (PHB/PCL) Blends

Lovera

Márquez

Balsamo

et al. 2007

Macro Chemistry & Physics

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Two types of mixtures were prepared by solution blending: high molecular weight polyhydroxybutyrate (PHB)/poly(ε‐caprolactone) (PCL) and PHB/low molecular weight chemically modified PCLs (mPCL). The morphology, crystallization, and enzymatic degradation of the blends were studied by differential scanning calorimetry, polarized light optical microscopy, scanning electron microscopy, 1H NMR, and weight loss measurements. In addition, enzymatic degradation studies were performed by an exposure to Aspergillus flavus. High molecular weight PHB/PCL blends were found to be immiscible in the entire composition range. Phenomena such as PCL fractionated crystallization and a decrease in PHB nucleation density were detected. When PHB was blended with mPCLs, the blends were partially miscible; two phases were formed, but the PHB‐rich phase exhibited clear signs of miscibility through a depression of both the Tm and the Tg of the PHB component (which was stronger with lower molecular weight mPCL), and an increase in the growth rate of PHB spherulites in the blends as compared to neat PHB or to the PHB component in the PHB/PCL blends. The biodegradation by a exposure to A. flavus showed that the blends are synergistically attacked in comparison to the homopolymers. Two factors may influence the improved degradation rate of the blends: the dispersion of the components and their crystallinity that was reduced in view of the fractionated crystallization and impurities transfer. In the case of the PHB/mPCL blends, the increased miscibility between the components caused a reduction in the degradation rate.magnified image

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“…Blending of PHB with another kind of polymer may improve its properties and processability. PHB has been reported to be miscible with a few chemically synthesized polymers, such as poly(ethylene oxide)(PEO) [4][5][6][7][8][9][10]. PEO is semi-crystalline, biocompatible, biodegradable, non-ionic and water-soluble polymer of considerable industrial significance which finds applications in many different branches of industry [11].…”

Section: Introductionmentioning

confidence: 99%

Thermal degradation of poly(3-hydroxybutyrate)/poly(ethylene oxide) blends: Thermogravimetric and kinetic analysis

Jakić

Vrandečić

2016

European Polymer Journal

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Biodegradable blends of high molecular weight poly(ethylene oxide) with poly(3-hydroxypropionic acid) and poly(3-hydroxybutyric acid): a miscibility study by DSC, DMTA and NMR spectroscopy

Cited by 31 publications

References 30 publications

Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid)

Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid)

Crystallization, Morphology, and Enzymatic Degradation of Polyhydroxybutyrate/Polycaprolactone (PHB/PCL) Blends

Thermal degradation of poly(3-hydroxybutyrate)/poly(ethylene oxide) blends: Thermogravimetric and kinetic analysis

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