Biodegradable magnesium implants for orthopedic applications

Waizy, Hazibullah; Seitz, Jan‐Marten; Reifenrath, Janin; Weizbauer, Andreas; Bach, Friedrich‐Wilhelm; Meyer‐Lindenberg, Andrea; Denkena, Berend; Windhagen, Henning

doi:10.1007/s10853-012-6572-2

Cited by 262 publications

(159 citation statements)

References 108 publications

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“…This result was supported by the results of Ma et al [67] who conducted a primarily electrochemical study of the biocorrosion of CP-Mg and also concluded that the presence of HCO 3 − initially increased the corrosion rate but eventually promoted the deposition of a protective corrosion layer which reduced the corrosion rate. However, these results [59,67] only provide a binary comparison between solutions with and without HCO 3 − . As previously discussed, HCO 3 − are an essential component to the buffer system shown in Equation (3).…”

supporting

confidence: 63%

“…These are different to traditional metallic biomaterials, which are dominated by corrosion resistant metals such as titanium, cobalt-chromium alloys and stainless steel [2]. The key application for biodegradable metals is for temporary medical implants and devices [3][4][5][6][7]. Biodegradable metals corrode and disappear after implantation.…”

Section: Medical Magnesium and Biocorrosionmentioning

confidence: 99%

“…Five immersion solutions were tested, and are presented in Table 3 with a comparison to blood plasma [51]. To maintain pH within physiological levels, they used the same buffer system as that by Abidin et al [24] between CO 2 gas and the dissolved NaHCO 3 . This system is covered in detail in the following section on carbonates, as well as in Section "pH and buffer systems".…”

Section: Mg(oh) + 2clmentioning

confidence: 99%

“…Another well-studied anion common to most SBFs and biological solutions is HCO 3 − . This is important predominately because of the role it plays in the respiratory buffer system [68].…”

mentioning

confidence: 99%

“…The presence of HCO 3 − appeared to initially stimulate corrosion, before aiding passivation due to the precipitation of MgCO 3 and CaCO 3 , which slightly lowered the corrosion rate and completely supressed any incidence of localised corrosion. This result was supported by the results of Ma et al [67] who conducted a primarily electrochemical study of the biocorrosion of CP-Mg and also concluded that the presence of HCO 3 − initially increased the corrosion rate but eventually promoted the deposition of a protective corrosion layer which reduced the corrosion rate. However, these results [59,67] only provide a binary comparison between solutions with and without HCO 3 − .…”

mentioning

confidence: 99%

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Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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supporting

confidence: 63%

Section: Medical Magnesium and Biocorrosionmentioning

confidence: 99%

Section: Mg(oh) + 2clmentioning

confidence: 99%

“…Another well-studied anion common to most SBFs and biological solutions is HCO 3 − . This is important predominately because of the role it plays in the respiratory buffer system [68].…”

mentioning

confidence: 99%