Biodegradable membrane‐covered stent from chitosan‐based polymers

Abstract

Membrane-covered devices could help treat disease of the vasculature such as aneurysm, rupture, and fistulas. They are also investigated to reduce embolic complication associated with revascularization of saphenous vein graft. The aim of this study is to design a clinically applicable biodegradable membrane-covered stent based on the natural polysaccharide chitosan, which has been developed. The mechanical properties of the membrane is optimized through blending with polyethylene oxide (70:30% Wt CH:PEO). The membrane was able to sustain the mechanical deformation of the supporting self-expandable metallic stents during its deployment. The membrane was demonstrated to resist physiological transmural pressure (burst pressure resistance >500 mm Hg) and presented a high-water permeation resistance (1 mL/cm(2) min(-1) at 120 mmHg). The CH-PEO membrane showed a good hemocompatibility in an ex vivo assay. Heparin and hyaluronan surface complexation with the membrane further reduced platelet adhesion by 50.1 and 63% (p = 0.05). The ability of the membrane-covered devices to be used as a drug reservoir was investigated using the nitric oxide donor sodium nitroprusside (SNP). SNP-loaded membranes displayed significantly reduced platelet adhesion.

The Application of Electrostatic Dry Powder Deposition Technology to Coat Drug-Eluting Stents

“…The results demonstrated that EDPDT has reduced platelet adhesion compared to the control uncoated stents and similar levels to the Cypher® stent. These findings are in good agreement with similar studies (33,34) suggesting that EDPDT can be effectively used for stent coating studies.…”

Surface Modification of Nickel/Titanium Alloy and Titanium Surfaces via a Polyelectrolyte Multilayer/Calcium Phosphate Hybrid Coating

“…[7,33,37] Moreover, calcium phosphate has been deposited on several LbL coatings and in all cases a reduced thrombogenicity has been observed. [34,38,70] As a result, we combine the advantages of (antibacterial) chitosan, (anticoagulant) heparin, and calcium phosphate with sizes below 100 nm in our coatings.…”

“…[2,4,6,10,17,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] Functional polymer coatings, including biofilms and plasma polymers, have attracted increasing interest in the recent past. [10,32,39,[41][42][43][44][45][46] This is because the polymer composition can be adapted for a special requirement like antibacterial activity.…”

Electrophoretic deposition of composite hydroxyapatite–chitosan–heparin coatings

“…Improved blood compatibility was achieved using chitosan-heparin complexes Kweon and Lim, 2003;Zhu et al, 2005) instead of pure chitosan. The complexes were utilized for the surface modification of various biomaterials (Thierry et al, 2005;Zhu et al, 2002;Wang et al, 2005;Yang and Lin, 2003;Yu et al, 2005;Fu et al, 2005; Lin et al, 2004) and fabrication of advanced implant materials with controlled release of heparin (Vasudev et al, 1997;Liao et al, 2005;He et al, 2007;Huang et al, 2007).…”