Biodegradable Mg–Zn–Ca-Based Metallic Glasses

Chao, Jin; Liu, Zhiyuan; Yu, Wei; Qin, Chunling; Yu, Hui; Wang, Zhifeng

doi:10.3390/ma15062172

Cited by 22 publications

(19 citation statements)

References 122 publications

(249 reference statements)

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“…Such an approach enforces the use of only completely bio-friendly components, such as Mg, which is the essential ingredient in the human body and can be absorbed and removed by the organism without causing adverse effects. Recently, the very dynamic development of this material group can be observed with many very similar compositions [ 167 ].…”

Section: Other Metallic Glassesmentioning

confidence: 99%

“…They are also characterized by a very good elastic strain of 1 to 2% (typical for metallic glasses) and lack of plasticity in compression [ 169 , 170 ] what is also connected with brittleness [ 171 ]. Typically, they are characterized by GFA allowing to produce diameters up to 5 mm [ 167 ]. These parameters can be further improved by the addition of alloying elements [ 169 , 172 ] or solid particles [ 170 ], however, usually by one at a time and in quantities of a few at.% as GFA of Mg-based is very susceptible to even minor compositional changes.…”

Section: Other Metallic Glassesmentioning

confidence: 99%

“…The corrosion resistance of Mg-based metallic glasses is low, typically measured in corrosion rates of about 0.15 to 1.7 mm per year in physiological solutions [ 168 , 169 ] what is although their desirable property. The corrosion resistance is still higher than for crystalline Mg-based alloys [ 167 ] what allows for their longer biodegradation times leading to full recovery. The second factor is lower hydrogen accumulation during slower resorption.…”

Section: Other Metallic Glassesmentioning

confidence: 99%

See 2 more Smart Citations

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Biały

Hasiak

Łaszcz

2022

JFB

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The continuous development of novel materials for biomedical applications is resulting in an increasingly better prognosis for patients. The application of more advanced materials relates to fewer complications and a desirable higher percentage of successful treatments. New, innovative materials being considered for biomedical applications are metallic alloys with an amorphous internal structure called metallic glasses. They are currently in a dynamic phase of development both in terms of formulating new chemical compositions and testing their properties in terms of intended biocompatibility. This review article intends to synthesize the latest research results in the field of biocompatible metallic glasses to create a more coherent picture of these materials. It summarizes and discusses the most recent findings in the areas of mechanical properties, corrosion resistance, in vitro cellular studies, antibacterial properties, and in vivo animal studies. Results are collected mainly for the most popular metallic glasses manufactured as thin films, coatings, and in bulk form. Considered materials include alloys based on zirconium and titanium, as well as new promising ones based on magnesium, tantalum, and palladium. From the properties of the examined metallic glasses, possible areas of application and further research directions to fill existing gaps are proposed.

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Section: Other Metallic Glassesmentioning

confidence: 99%

Section: Other Metallic Glassesmentioning

confidence: 99%

Section: Other Metallic Glassesmentioning

confidence: 99%

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Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Biały

Hasiak

Łaszcz

2022

JFB

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“…In vitro and in vivo tests have also validated the advantages of Mg–Ca-based alloys with other chemical elements with high cell viability and good osteogenesis activity. However, efforts are still required to overcome the existing challenges before final successful clinical applications [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Examination of Degradation and In Vivo Biocompatibility of Some Mg-0.5Ca-xY Alloys in Sprague Dawley Rats

et al. 2022

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The medical field has undergone constant development in recent years, and a segment of this development is occupied by biodegradable alloys. The most common alloys in this field are those based on Mg, their main advantage being the ability to degrade gradually, without affecting the patient, and also their ability to be fully absorbed by the human body. One of their most important conditions is the regeneration and replacement of human tissue. Tissue can be engineered in different ways, one being tissue regeneration in vivo, which can serve as a template. In vivo remodeling aims to restore tissue or organs. The key processes of tissue formation and maturation are: proliferation (sorting and differentiation of cells), proliferation and organization of the extracellular matrix, biodegradation of the scaffold-remodeling, and potential tissue growth. In the present paper, the design of the alloys in the Mg-Ca-Y system is formed from the beginning using high-purity components, Mg-98.5%, master-alloys: Mg-Y (70 wt.%–30 wt.%) and Mg-Ca (85 wt.%–15 wt.%). After 8 weeks of implantation, the degradation of the implanted material is observed, and only small remaining fragments are found. At the site of implantation, no inflammatory reaction is observed, but it is observed that the process of integration and reabsorption, over time, accentuates the prosaic surface of the material. The aim of the work is to test the biocompatibility of magnesium-based alloys on laboratory rats in order to use these alloys in medical applications. The innovative parts of these analyses are the chemical composition of the alloys used and the tests performed on laboratory animals.

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“…Bulk metallic glasses (BMGs) are a relatively new class of metallic materials developed over the past couple of decades with the first BMG being developed during the 80s . Unlike conventional crystalline materials, BMGs exhibit no long-range atomic order and have shown a promising potential for biomedical applications. − A combination of high strength, excellent corrosion and wear resistance, and relatively low Young’s modulus (80–100 GPa), arising from the unique disordering of the atomic structure, make BMGs potential candidates for orthopedic applications and particularly for load-bearing implants . Despite advancements in the development of biomedical BMGs made during the past decade, the production of BMGs in larger dimensions and complex geometries has remained challenging.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of a Zr-Based Metallic Glass Enabled by Additive Manufacturing

Larsson

Marattukalam

Paschalidou

et al. 2022

ACS Appl. Bio Mater.

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The present work explored the use of the selective laser melting (SLM) technique to develop a Zr-based bulk metallic glass (BMG) and investigate the influence of the process parameters on obtaining different levels of surface roughness. Moreover, the potential of the additively manufactured BMG Zr59.3Cu28.8Al10.4Nb1.5 (trade name AMLOY-ZR01) as an implant material was studied by evaluating the osteoblastic cell response to the alloy and its stability under simulated biological environments. The materials were characterized in terms of degree of crystallinity, surface roughness, and morphology, followed by a systematic investigation of the response of the MC3T3-E1 preosteoblastic cell line to the as-printed samples. The materials supported cell proliferation and differentiation of the preosteoblastic cells, with results comparable to the reference material Ti-6Al-4V. The surface microroughness and surface morphology (porous or groove-type laser tracks) investigated in this study did not have a significant effect on modulating the cell response. Ion release experiments showed a large increase in ion release under inflammatory conditions as compared to regular physiological conditions, which could be attributed to the increased local corrosion under inflammatory conditions. The findings in this work showed that the surface roughness of the additively manufactured BMG AMLOY-ZR01 can be tailored by controlling the laser power applied during the SLM process. The favorable cell response to the as-printed AMLOY-ZR01 represents of a significant advancement of the investigation of additively manufactured BMGs for orthopedic applications, while the results of the ion release study highlights the effect that inflammatory conditions could have on the degradation of the alloy.

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Biodegradable Mg–Zn–Ca-Based Metallic Glasses

Cited by 22 publications

References 122 publications

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Long-Term Examination of Degradation and In Vivo Biocompatibility of Some Mg-0.5Ca-xY Alloys in Sprague Dawley Rats

Biocompatibility of a Zr-Based Metallic Glass Enabled by Additive Manufacturing

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