Biodegradable microspheres containing poly(ɛ-caprolactone)–Pluronic block copolymers for temperature-responsive release of proteins

Lee, Jung Im; Yoo, Hyuk Sang

doi:10.1016/j.colsurfb.2007.07.008

Cited by 21 publications

(10 citation statements)

References 19 publications

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“…The obtained results can be compared to previously report performed on PCL and Pluronic F-127 combination, where the appearance of pores on the surface was observed due to the presence of the Pluronic F-127, which also resulted in the increase of the hydrophilicity of the PCL ( Figure 4K) 32,[53][54][55] To probe the changes in hydrophobicity, the CA was measured by forming a film of PCL-M, PCL-CPO-M, and PCL-CPO-F-M deposited by electrospray on glass substrate. Each CA value represents an average of 20 measurements.…”

Section: Resultssupporting

confidence: 69%

<p>Electrospraying Oxygen-Generating Microparticles for Tissue Engineering Applications</p>

Morais¹,

Wang²,

Vieira³

et al. 2020

IJN

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Background: The facile preparation of oxygen-generating microparticles (M) consisting of Polycaprolactone (PCL), Pluronic F-127, and calcium peroxide (CPO) (PCL-F-CPO-M) fabricated through an electrospraying process is disclosed. The biological study confirmed the positive impact from the oxygen-generating microparticles on the cell growth with high viability. The presented technology could work as a prominent tool for various tissue engineering and biomedical applications. Methods: The oxygen-generated microparticles fabricated through electrospraying processes were thoroughly characterization through various methods such as X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) analysis, and scanning electron microscopy (SEM)/SEM-Energy Dispersive Spectroscopy (EDS) analysis. Results: The analyses confirmed the presence of the various components and the porous structure of the microparticles. Spherical shape with spongy characteristic microparticles were obtained with negative charge surface (ζ =-16.9) and a size of 17.00 ± 0.34 μm. Furthermore, the biological study performed on rat chondrocytes demonstrated good cell viability and the positive impact of increasing the amount of CPO in the PCL-F-CPO-M. Conclusion: This technological platform could work as an important tool for tissue engineering due to the ability of the microparticles to release oxygen in a sustained manner for up to 7 days with high cell viability.

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Section: Resultssupporting

confidence: 69%

<p>Electrospraying Oxygen-Generating Microparticles for Tissue Engineering Applications</p>

Morais¹,

Wang²,

Vieira³

et al. 2020

IJN

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“…To date, a number of novel antibiotic analogs and nanomate-Synthetic polymers are the second category of materials appealing for the design of polymeric nanoparticles and include polylactides (PLA), polyglycolides (PGA), poly(ethylene glycol) (PEG), polycaprolactone (PCL), poly(acrylic acid) derivatives (PAA) and copolymers such as poly(lactide co-glycolides) (PLGA), poly(ε-caprolactone)-Pluronic, and poly(ethylene glycol)-poly(2-methyl-2-carboxyl-propylene carbonate) (MPEG-PMBC), etc. [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

Michalak¹,

Głuszek²,

Piktel³

et al. 2016

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The increased prevalence of antibiotic-resistant pathogens requires additional efforts to develop new antimicrobial agents and alternative methods to prevent and treat infections. In response to this challenge, a variety of nanotechnology-based tools are currently being designed and thoroughly investigated. To date, a considerable number of studies have reported increased activity of antibiotic-conjugated polymeric nanoparticles against bacteria and fungi associated with various infections, including those caused by drug-resistant pathogens. Importantly, high biocompatibility of these structures coupled with enhanced biological activity and improved pharmacokinetic properties supports the potential of these nanosystems as new tools to treat infections. In this review, we summarize the synthesis of polymer-based nanoparticles and describe their mechanism of action. We also highlight the recent advances in the application of antibiotic-conjugated polymeric nanoparticles as novel antimicrobial agents. StreszczenieStale narastająca lekooporność drobnoustrojów wymusza konieczność rozwoju alternatywnych metod profilaktyki i terapii zakażeń, a także uzasadnia prace nad nowymi lekami o aktywności przeciwdrobnoustrojowej. Realizacja tego celu jest moż-liwa dzięki zastosowaniu osiągnięć z zakresu nanotechnologii. Zwiększająca się liczba doniesień literaturowych potwierdza znaczną aktywność przeciwdrobnoustrojową nanocząstek polimerowych skoniugowanych z klasycznymi antybiotykami, co może zostać wykorzystane w terapii infekcji o charakterze bakteryjnym i grzybiczym, również tych wywoływanych przez patogeny lekooporne. Wysoka biokompatybilność nanocząstek polimerowych, a także możliwość zwiększania aktywności przeciwdrobnoustrojowej i poprawy parametrów farmakokinetycznych stosowanych obecnie chemioterapeutyków, wskazuje na możliwość zastosowania nanostruktur w nowoczesnej terapii chorób infekcyjnych. W niniejszej pracy podsumowano metody syntezy nanosystemów opartych na nanocząstkach polimerowych, a także opisano mechanizm ich działania. Przedstawione zostały również najnowsze osiągnięcia w syntezie nanocząstek skoniugowanych z antybiotykami, pozwalające na ich zastosowanie w terapii infekcji o charakterze bakteryjnym i grzybiczym.

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“…However, on a few practical application fields of these composite particles, it is strongly desired that the composite particles are prepared by using biodegradable materials [3]- [6]. For an example, it has been tried to prepare microcapsules or composite particles, which contain agricultural medicine or pheromone for noxious insects, by biodegradable materials based on natural elemental materials, because it may be expected that the biodegradable shell materials should vanish after complete release of core material and environmental pollution could be prevented [7]- [9].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Composite Particles Made of Biodegradable Polymer and a Few Additives with Phase Separation Followed by Drying-in-Liquid

Kutsuwada¹,

Taguchi²

2015

JEAS

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It was tried to prepare the biodegradable composite particles by the phase separation method followed by the drying-in-liquid method. The composite particles were made of poly-ε-caprolactone, quaternary ammonium, carbon black and wax. In the experiment, acetone and water were selected as a good solvent and a poor solvent for poly-ε-caprolactone, quaternary ammonium and wax, respectively. The composite particles were prepared by changing the surfactant species and their concentration, the feeding velocity of water and the weight ratio of poly-ε-caprolactone with larger molecular weight to one with smaller molecular weight. The composite particles with the inner structure in which carbon black, quaternary ammonium and wax were coated well with poly-ε-caprolactone could be prepared by the preparation method presented in this study. The structure and the mean diameter of composite particles were strongly affected by the feeding velocity of water. The higher the feeding velocity of water, the larger the mean diameter of composite particles. The mean diameter was drastically decreased with the surfactant concentration and increased with the added amount of poly-ε-caprolactant with larger molecular weight.

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Biodegradable microspheres containing poly(ɛ-caprolactone)–Pluronic block copolymers for temperature-responsive release of proteins

Cited by 21 publications

References 19 publications

<p>Electrospraying Oxygen-Generating Microparticles for Tissue Engineering Applications</p>

<p>Electrospraying Oxygen-Generating Microparticles for Tissue Engineering Applications</p>

Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

Preparation of Composite Particles Made of Biodegradable Polymer and a Few Additives with Phase Separation Followed by Drying-in-Liquid

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