Biodegradable MnFe-hydroxide nanocapsules to enable multi-therapeutics delivery and hypoxia-modulated tumor treatment

Liao, Linhua; Cen, Dong; Fu, Yongjian; Liu, Bin; Fang, Chao; Wang, Yifan; Cai, Xiujun; Li, Xiang; Wu, Hao Bin; Han, Gaorong

doi:10.1039/d0tb00243g

Cited by 10 publications

(4 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The H‐CF was prepared by growing a cobalt‐iron hydroxide layer on the surface of silica particles synthesized according to the Stöber method, followed by the removal of the SiO 2 template via alkaline etching referring to our previous work. [ 48 ] The SiO 2 particle size was ≈60 nm, while the sizes of both SiO 2 @CoFe(OH) x and H‐CF were ≈00 nm (Figure S3, Supporting Information). The hollow structure of H‐CF was displayed by the lower density inside the nanoparticle.…”

Section: Resultsmentioning

confidence: 99%

Hollow CoFe Nanozymes Integrated with Oncolytic Peptides Designed via Machine‐Learning for Tumor Therapy

Li,

Xu,

et al. 2024

Small

Self Cite

View full text Add to dashboard Cite

Developing novel substances to synergize with nanozymes is a challenging yet indispensable task to enable the nanozyme‐based therapeutics to tackle individual variations in tumor physicochemical properties. The advancement of machine learning (ML) has provided a useful tool to enhance the accuracy and efficiency in developing synergistic substances. In this study, ML models to mine low‐cytotoxicity oncolytic peptides are applied. The filtering Pipeline is constructed using a traversal design and the Autogluon framework. Through the Pipeline, 37 novel peptides with high oncolytic activity against cancer cells and low cytotoxicity to normal cells are identified from a library of 25,740 sequences. Combining dataset testing with cytotoxicity experiments, an 80% accuracy rate is achieved, verifying the reliability of ML predictions. Peptide C2 is proven to possess membranolytic functions specifically for tumor cells as targeted by Pipeline. Then Peptide C2 with CoFe hollow hydroxide nanozyme (H‐CF) to form the peptide/H‐CF composite is integrated. The new composite exhibited acid‐triggered membranolytic function and potent peroxidase‐like (POD‐like) activity, which induce ferroptosis to tumor cells and inhibits tumor growth. The study suggests that this novel ML‐assisted design approach can offer an accurate and efficient paradigm for developing both oncolytic peptides and synergistic peptides for catalytic materials.

show abstract

Section: Resultsmentioning

confidence: 99%

Hollow CoFe Nanozymes Integrated with Oncolytic Peptides Designed via Machine‐Learning for Tumor Therapy

Li,

Xu,

et al. 2024

Small

Self Cite

View full text Add to dashboard Cite

show abstract

“…After co-loading hydrophilic DOX and hydrophobic paclitaxel (PTX), the nanosystem showed an effective combination of chemotherapy against liver cancer. Liao et al 88 synthesized a Mn hydroxide nanocapsule with a high loading capacity and strong catalytic activity, which could effectively relieve hypoxia in tumor tissues and improve the synergistic anticancer effect. Yan et al 89 synthesized CoMn-LDH nanosheets using a bottom-up approach and surface modification with photosensitizer chloride e6 (Ce6).…”

Section: Mn-based Mri Nanoprobe-mediated Targeted Cancer Theranosticsmentioning

confidence: 99%

Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management

Du,

Zhao,

Cui

et al. 2023

IJN

View full text Add to dashboard Cite

Manganese (Mn)-based magnetic resonance imaging (MRI) has become a competitive imaging modality for cancer diagnosis due to its advantages of non-invasiveness, high resolution and excellent biocompatibility. In recent years, a variety of Mn contrast agents based on different material systems have been synthesized, and a series of multi-purpose Mn nanocomposites have also emerged, showing satisfactory relaxation efficiency and MRI performance thus possess the transformation and application value in MRI-synergized cancer diagnosis and treatment. This tutorial review starts from the classification and properties of Mn-based nanomaterials, and then summarizes various preparation and functionalization strategies of nanosized Mn contrast agents, especially focuses on the latest progress of Mn contrast agents in MRI-synergized precise cancer theranostics. In addition, present review also discusses the current clinical transformation obstacles such as unclear molecular mechanisms, potential nanotoxicity, and scale production constraints. This paper provides evidence-based recommendations about the future prospects of multifunctional nanoplatforms, as well as technical guidance and panoramic expectations for the design of clinically meaningful cancer management programs.

show abstract

“…318,319 For example, Liao et al developed H-MnFe(OH)x nanocapsules with hollow structures of about 90 nm in size by selecting silica NPs as hard templates for the in situ growth of MnFe(OH)x, which could accommodate a variety of therapeutic drugs. 320 In vivo experiments showed that Mn 2+ /Fe 3+ released from nanocapsule could effectively catalyze the breakdown of H 2 O 2 to O 2 in the tumor microenvironment, thus significantly improving the efficacy of PDT/chemotherapy synergistic treatment. It is well known that nanorods have a significant advantage over dotted NPs in terms of tumor enrichment and cellular endocytosis.…”

Section: Light-responsive Npsmentioning

confidence: 99%

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

Xing

Zhou

et al. 2023

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Biodegradable MnFe-hydroxide nanocapsules to enable multi-therapeutics delivery and hypoxia-modulated tumor treatment

Abstract: Fine nanocapsules based on MnFe hydroxides, showing high loading capacity, O2 induction and biodegradation, were synthesized for effective synergistic therapies.

Cited by 10 publications

References 66 publications

Hollow CoFe Nanozymes Integrated with Oncolytic Peptides Designed via Machine‐Learning for Tumor Therapy

Hollow CoFe Nanozymes Integrated with Oncolytic Peptides Designed via Machine‐Learning for Tumor Therapy

Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

Contact Info

Product

Resources

About