Biodegradable Nanospheres - Current Status

Abstract

Nanospheres are polymeric matrix of spherical shape that ranges in size between 10- 200 nm in diameter. The drug is dissolved, entrapped, encapsulated or attached to the matrix of polymer. The nature of nanospheres can be amorphous or crystalline, and they potentiate to protect the drug from chemical and enzymatic degradation. In the matrix of this polymer, a drug will evenly distribute as well as physically and uniformly disperse and can enclose a variety of drugs, enzymes and, genes, providing a long circulation time. Nanospheres have the capability to convert poorly soluble, poorly absorbed and labile biologically active substance into promising deliverable drugs. This review focuses on the mechanism for synthesis of nano-based drug delivery systems, characterization, and application of biodegradable nanospheres and mainly on successful formulations based on biodegradable nanospheres.

Dehydroacetic acid a privileged medicinal scaffold: A concise review

“…Rao et al synthesized some important oxovanadium(IV), Mn(II), Fe(II), Cu(II), Co(II), and Ni(II) metal complexes with a novel quadridentate ligand prepared from DHA and carbohydrazide. [ 93 ] The synthesized complexes were assayed in vitro for fungicidal activities against A. niger . All the tested compounds exhibited about 70.5 % to 100 % inhibition which is much better with than the ligand.…”

“…DHA is also an effective chelating ligand that serves as a flexible precursor for synthesizing several metal complexes with significant pharmacological properties. [ 16,17 ] It was also noticed in most of the cases, the complexation of DHA derivatives with a metal atom led to significant enhancement in the activity. Several reports available in the literature showed that small structural changes in DHA can lead to more bioactive molecules with improved potency, decreased toxicity, more excellent metabolic stability, and bioavailability.…”