Biodegradable Natural Polymers for Biomedical Applications

Parveen, Israt; Mahmud, Md. Iqbal; Khan, Ruhul A.

doi:10.32861/sr.53.67.80

Cited by 8 publications

(7 citation statements)

References 1 publication

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“…Various natural polymers such as chitosan, collagen, alginate, cellulose, and gelatin and those from synthetic polymers like poly-lactic acid (PLA), polyethylene glycol (PEG), polycaprolactone (PCL), and poly lactic-co-glycolic acid (PLGA) have been studied for their valuable applications as biosensors, gene delivery vectors, drug delivery systems, and in tissue engineering [80]. The most widely used natural polymers in the field of biomedical applications are bacterial polyesters [81,82] (e.g., bacterial cellulose [83,84]), proteins (e.g., collagen, silk [83,85], gelatin [84], and fibrin), and polysaccharides (e.g., alginate [80], hyaluronic acid [81], and chitosan [82]), which stand out as extensively employed natural polymers in the realm of biomedical applications [86]. These polymers find utility in diverse formats, such as 3D porous scaffolds, hydrogels, nanoparticles, composites, and absorbent sponges [87].…”

Section: Important Properties Of Polymers Used For Biomedical Applica...mentioning

confidence: 99%

Hybrid and Single-Component Flexible Aerogels for Biomedical Applications: A Review

Fijalkowski,

Ali,

Qamer

et al. 2023

Gels

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The inherent disadvantages of traditional non-flexible aerogels, such as high fragility and moisture sensitivity, severely restrict their applications. To address these issues and make the aerogels efficient, especially for advanced medical applications, different techniques have been used to incorporate flexibility in aerogel materials. In recent years, a great boom in flexible aerogels has been observed, which has enabled them to be used in high-tech biomedical applications. The current study comprises a comprehensive review of the preparation techniques of pure polymeric-based hybrid and single-component aerogels and their use in biomedical applications. The biomedical applications of these hybrid aerogels will also be reviewed and discussed, where the flexible polymeric components in the aerogels provide the main contribution. The combination of highly controlled porosity, large internal surfaces, flexibility, and the ability to conform into 3D interconnected structures support versatile properties, which are required for numerous potential medical applications such as tissue engineering; drug delivery reservoir systems; biomedical implants like heart stents, pacemakers, and artificial heart valves; disease diagnosis; and the development of antibacterial materials. The present review also explores the different mechanical, chemical, and physical properties in numerical values, which are most wanted for the fabrication of different materials used in the biomedical fields.

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Section: Important Properties Of Polymers Used For Biomedical Applica...mentioning

confidence: 99%

Hybrid and Single-Component Flexible Aerogels for Biomedical Applications: A Review

Fijalkowski,

Ali,

Qamer

et al. 2023

Gels

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“…Chitosan: 18,19,20 Chitin is a white, hard, inelastic mucopolysaccharide that is the supporting material of crustaceans and insects. It is a homopolymer consisting of N-acetyl glucosamine units linked through a β (1-4) linkage and has a 3D α-helical configuration, which is stabilized by hydrogen bonding.…”

Section: Fig 2: Chemical Structure Of Pectin 16 17mentioning

confidence: 99%

“…Pectin: 16,17,18 Pectin is a naturally occurring biopolymer that is finding increasing applications in the pharmaceutical and biotechnology industry. Pectin has been widely studied and published but is difficult to characterize as a model system due to the heterogeneous nature of the polymer.…”

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confidence: 99%

Untitled

2021

IJPSR

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“…Naturally sourced polymers have been used for biomedical applications [ 11 , 12 , 13 ]. Among these, chitosan (CS) is a polysaccharide with abundant amino functionality derived from the deacetylation of chitin sourced from natural marine crab shells.…”

Section: Introductionmentioning

confidence: 99%

Fungal Carboxymethyl Chitosan-Impregnated Bacterial Cellulose Hydrogel as Wound-Dressing Agent

Suneetha

Won

et al. 2023

Gels

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Bacterial cellulose (BC) produced by Gluconoacetobacter hansenii is a suitable polymeric fiber network for wound-dressing purposes, but its lack of antibacterial properties limits it from healing bacterial wounds. We developed hydrogels by impregnating fungal-derived carboxymethyl chitosan to BC fiber networks using a simple solution immersion method. The CMCS–BC hydrogels were characterized using various characterization techniques such as XRD, FTIR, water contact angle measurements, TGA, and SEM to know the physiochemical properties. The results show that the impregnation of CMCS into BC fiber networks greatly influences BC’s improving hydrophilic nature, which is crucial for wound healing applications. Furthermore, the CMCS–BC hydrogels were studied for biocompatibility analysis with skin fibroblast cells. The results revealed that by increasing the CMCS content in the BC, biocompatibility, cell attachment, and spreading capacity also increase. The antibacterial activity of CMCS–BC hydrogels is shown using the CFU method against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). As a result, the CMCS–BC hydrogels exhibit more suitable antibacterial properties than those without BC due to the CMCS having amino groups that enhance antibacterial properties. Therefore, CMCS–BC hydrogels can be considered suitable for antibacterial wound dressing applications.

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Biodegradable Natural Polymers for Biomedical Applications

Cited by 8 publications

References 1 publication

Hybrid and Single-Component Flexible Aerogels for Biomedical Applications: A Review

Hybrid and Single-Component Flexible Aerogels for Biomedical Applications: A Review

Untitled

Fungal Carboxymethyl Chitosan-Impregnated Bacterial Cellulose Hydrogel as Wound-Dressing Agent

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