Biodegradable polymer needle with various tip angles and consideration on insertion mechanism of mosquito's proboscis

Aoyagi, Shigeaki; Izumi, Hayato; Fukuda, Mitsuo

doi:10.1016/j.sna.2007.06.007

Cited by 147 publications

(133 citation statements)

References 2 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…Aoyagi 14 found that a more pointed tip had lower penetration force. They examined 4 angles: 15, 30, 45 1nd 75 degrees.…”

Section: Improve the Penetration Toolsmentioning

confidence: 99%

“…It is a delicate mechanism consisting of 7 elements 13,14 as illustrated in figure 1. Outermost is the labium, which like a sheath covers the other 6 elements that together forms the fascicle to be inserted into the skin.…”

Section: Skin Penetration In Mosquitoesmentioning

confidence: 99%

“…Aoyagi et al describes how the labium bends as the facile penetrates the skin and they observed a higher frequency of 30 Hz during insertion. They also noticed that as the labrum bended the tip of the labrum opened and closed giving tension to the skin 14 . Choumet measured the duration of the stinging process for a Anopheles gambiae mosquito and found median probing time to be 142 s and median feeding time to be 240s 16 .…”

Section: Skin Penetration In Mosquitoesmentioning

confidence: 99%

“…The tip of the labium of the mosquito splits as the proboscis is pressed towards the skin 14 . The labium therefore stretches the skin increasing the skin tension in the penetration area.…”

Section: Reducing Skin Resistancementioning

confidence: 99%

See 3 more Smart Citations

Mosquito inspired medical needles

et al. 2017

View full text Add to dashboard Cite

The stinging proboscis in mosquitos have diameters of only 40-100 µm which is much less than the thinnest medical needles and the mechanics of these natural stinging mechanisms have therefore attracted attention amongst developers of injection devises. The mosquito use a range of different strategies to lower the required penetration force hence allowing a thinner and less stiff proboscis structure. Earlier studies of the mosquito proboscis insertion strategies have shown how each of the single strategies reduces the required penetration force. The present paper gives an overview of the advanced set of mechanisms that allow the mosquito to penetrate human skin and also presents other biological mechanisms that facilitate skin penetration. Results from experiments in a skin mimic using biomimetic equivalents to the natural mechanisms are presented. This includes skin stretching, insertion speed and vibration. Combining slow insertion speed with skin tension and slow vibration reduces the penetration force with 40%.

show abstract

“…Aoyagi 14 found that a more pointed tip had lower penetration force. They examined 4 angles: 15, 30, 45 1nd 75 degrees.…”

Section: Improve the Penetration Toolsmentioning

confidence: 99%

Section: Skin Penetration In Mosquitoesmentioning

confidence: 99%

Section: Skin Penetration In Mosquitoesmentioning

confidence: 99%

“…The tip of the labium of the mosquito splits as the proboscis is pressed towards the skin 14 . The labium therefore stretches the skin increasing the skin tension in the penetration area.…”

Section: Reducing Skin Resistancementioning

confidence: 99%

See 2 more Smart Citations

Mosquito inspired medical needles

et al. 2017

View full text Add to dashboard Cite

show abstract

“…4,5) Although the first silicon MNs were of being too brittle and possessing non-biocompatible nature, 6,7) intensive research since then has yielded many pharmaceutical, polymer-based MN systems as alternatives. 2,[8][9][10][11][12][13][14][15][16] Micro manufacturing techniques, 17,18) deduction of suitable polymers for MNs and optimization of the formulation parameters to produce MNs that possess characteristics like solubility, swelling, and biodegradability were previously published. 8) Polymeric MNs have great potential to start a million dollar market up by revolutionizing not only the drug delivery systems (conventional transdermal patches and hypodermic needles), but also drug monitoring devices (both bench top and portable systems).…”

mentioning

confidence: 99%

Novel Use of Pectin as a Microneedle Base

Demir

Kerımoğlu

2015

Chem. Pharm. Bull.

View full text Add to dashboard Cite

4D Printing of a Bioinspired Microneedle Array with Backward‐Facing Barbs for Enhanced Tissue Adhesion

Han

Morde

Mariani

et al. 2020

Adv Funct Materials

234

146

View full text Add to dashboard Cite

Microneedle (MN), a miniaturized needle with a length‐scale of hundreds of micrometers, has received a great deal of attention because of its minimally invasive, pain‐free, and easy‐to‐use nature. However, a major challenge for controlled long‐term drug delivery or biosensing using MN is its low tissue adhesion. Although microscopic structures with high tissue adhesion are found from living creatures in nature (e.g., microhooks of parasites, barbed stingers of honeybees, quills of porcupines), creating MNs with such complex microscopic features is still challenging with traditional fabrication methods. Here, a MN with bioinspired backward‐facing curved barbs for enhanced tissue adhesion, manufactured by a digital light processing 3D printing technique, is presented. Backward‐facing barbs on a MN are created by desolvation‐induced deformation utilizing cross‐linking density gradient in a photocurable polymer. Barb thickness and bending curvature are controlled by printing parameters and material composition. It is demonstrated that tissue adhesion of a backward‐facing barbed MN is 18 times stronger than that of barbless MN. Also demonstrated is sustained drug release with barbed MNs in tissue. Improved tissue adhesion of the bioinspired MN allows for more stable and robust performance for drug delivery, biofluid collection, and biosensing.

show abstract

Biodegradable polymer needle with various tip angles and consideration on insertion mechanism of mosquito's proboscis

Cited by 147 publications

References 2 publications

Mosquito inspired medical needles

Mosquito inspired medical needles

Novel Use of Pectin as a Microneedle Base

4D Printing of a Bioinspired Microneedle Array with Backward‐Facing Barbs for Enhanced Tissue Adhesion

Contact Info

Product

Resources

About