2017
DOI: 10.1016/s1878-6480(17)30431-7
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Biodegradable polymeric nanocapsules prevent cardiotoxicity of antitrypanosomal lychnopholide

Abstract: Chagas disease is a neglected parasitic disease caused by the protozoan Trypanosoma cruzi. New antitrypanosomal options are desirable to prevent complications, including a high rate of cardiomyopathy. Recently, a natural substance, lychnopholide, has shown therapeutic potential, especially when encapsulated in biodegradable polymeric nanocapsules. However, little is known regarding possible adverse effects of lychnopholide. Here we show that repeated-dose intravenous administration of free lychnopholide (2.0 m… Show more

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