Biodegradable Polymeric Nanoparticles as Templates for Biomimetic Mineralization of Calcium Phosphate

Ethirajan, Anitha; Musyanovych, Anna; Landfester, Katharina

doi:10.1002/macp.201000694

Cited by 15 publications

(8 citation statements)

References 46 publications

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“…[50][51][52][53] It is noteworthy that the technique described here can be easily adapted to other microparticle platforms, such as polyester microspheres, alginate beads, and chitosan microspheres. [ 54,55 ] For some of these substrates (e.g., alginate, [ 56 ] mineral coatings similar to those described here can be formed in an identical manner to our current study. In other cases (e.g., polyester microspheres, [ 21,57 ] a one-step surface modifi cation such as alkaline treatment allows for surface functionalization, which in turn enables mineral coating nucleation and growth.…”

Section: Discussionsupporting

confidence: 54%

“…[54,55] For some of these substrates (e.g., alginate, [56] mineral coatings similar to those described here can be formed in an identical manner to our current study. In other cases (e.g., polyester microspheres, [21,57] a one-step surface modification such as alkaline treatment allows for surface functionalization, which in turn enables mineral coating nucleation and growth.…”

Section: Discussionmentioning

confidence: 65%

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Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery

Khalil

Dang

et al. 2014

Adv Funct Materials

118

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There is an increasing need to control the type, quantity, and timing of growth factors released during tissue healing. Sophisticated delivery systems offering the ability to deliver multiple growth factors with independently tunable kinetics are highly desirable. Here, a multilayered, mineral coated micro-particle (MCMs) platform that can serve as an adaptable dual growth factor delivery system is developed. Bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) are bound to the mineral coatings with high binding efficiencies of up to 80%. BMP-2 is firstly bound onto a 1st mineral coating layer; then VEGF is bound onto a 2nd mineral coating layer. The release of BMP-2 is sustained over a period of 50 days while the release of VEGF is a typical two-phase release with rapid release in the first 14 days and more sustained release for the following 36 days. Notably, the release behaviors of both growth factors can be independently tailored by changing the intrinsic properties of the mineral coatings. Furthermore, the release of BMP-2 can be tuned by changing the thickness of the 2nd layer. This injectable microparticle based delivery platform with tunable growth factor release has immense potential for applications in tissue engineering and regenerative medicine.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 65%

Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery

Khalil

Dang

et al. 2014

Adv Funct Materials

118

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“…[76] The hybrid particles could be applied for bone-repair applications, as coatings on implants, or as a building block for the scaffold fabrication that might be able to nucleate and grow new bone material. Although, such encapsulation within the polymeric matrix has already been reported in the form of microspheres, [66] encapsulation in the form of nanoparticles possess added advantages as they offer several possibilities for final applications owing to their large surface area and homogeneity.…”

Section: Synthetic Biodegradable Polymer-based Nanoparticlesmentioning

confidence: 99%

“…The hybrid particles can be formed by encapsulating the preformed nano-hydroxyapatite into the biodegradable polyA C H T U N G T R E N N U N G (lactic acid) matrix by slightly optimizing the miniemulsion technique. [74,76] As the nanoapatite crystals are relatively hydrophilic and the polymer hydrophobic, the encapsulation in aqueous phase is difficult. The polymer-inorganic interface compatibility plays a crucial role in the encapsulation efficiency.…”

Section: Synthetic Biodegradable Polymer-based Nanoparticlesmentioning

confidence: 99%

“…Thus, the degradation caused by random hydrolytic cleavage of ester bonds due to the alkali treatment (providing increased density of anionic functional group) as well as the intrinsic degradation that was present in the nanoparticles prior to any treatment (due to the ultrasonication step) were taken for granted and these particles were exploited as templates for the calcium phosphate (CaP) mineralization. [76] The hydrolysis treatment was performed at 37 8C for a prolonged time by the addition of alkaline NaOH. The increase in the amount of carboxylic and hydroxyl groups, due to the scission of polyester chains, serves to bind the calcium ions to the polymeric template particle, promoting heterogeneous mineral growth.…”

Section: Synthetic Biodegradable Polymer-based Nanoparticlesmentioning

confidence: 99%

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Functional Hybrid Materials with Polymer Nanoparticles as Templates

Ethirajan

Landfester

2010

Chemistry A European J

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The use of polymeric nanoparticles as templates for producing inorganic materials is an intriguing approach as it offers the feasibility of synthesizing hybrid organic-inorganic functional materials for a broad spectrum of applications ranging from optoelectronics to biomedicine. The concept of using polymer nanoparticles as templates to produce hybrid materials has several advantages. On the one hand, the entire geometry of the nanoparticle can be used as a confined nano-environment to let the inorganic material grow inside the particle. On the other hand, the high surface area of nanoparticle can be exploited to let the inorganic material grow on the outside surface of the particles. One such application is presented here, in which polymer nanoparticles were used as biomimetic template to produce composite nanoparticles made of the bone mineral hydroxyapatite (HAP). The synthesized hybrid particle has a great potential to be used as regenerative filler or as scaffold for nucleation and growth of new bone material. In addition to be applied as coatings on implants, these nanoparticles also offer the feasibility of being injected directly into the damaged part or administered intravenously with functionalization. Within this overview, we will mainly focus on different polymer nanoparticles obtained by the miniemulsion technique and the different possibilities for them to be used as templates for the biomimetic mineralization of calcium phosphate in the aqueous phase.

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Mussel‐Inspired Tough Hydrogel with In Situ Nanohydroxyapatite Mineralization for Osteochondral Defect Repair

Gan

Wang

Xie

et al. 2019

Adv Healthcare Materials

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Repairing osteochondral defects is a considerable challenge because it involves the breakdown of articular cartilage and underlying bone. Traditional hydrogels with a homogenized single‐layer structure cannot fully restore the function of osteochondral cartilage tissue. In this study, a mussel‐inspired hydrogel with a bilayer structure is developed to repair osteochondral defects. The hydrogel is synthesized by simultaneously polymerizing two layers using a one‐pot method. The resulting upper and lower gelatin methacryloyl‐polydopamine hydrogel layers are used as cartilage and subchondral bone repair layers, respectively. Polydopamine‐induced hydroxyapatite in situ mineralization takes place in the lower layer to mimic the structure of subchondral bone. The bilayer hydrogel exhibits good mechanical properties for the synergistic effect of covalent and noncovalent bonds, as well as nanoreinforcement of mineralized hydroxyapatite. To improve the tissue‐inducibility of hydrogels, transforming growth factor β3 is immobilized in the upper layer to induce cartilage regeneration, while bone morphogenetic protein 2 is immobilized in the lower layer to induce bone regeneration. Bone and cartilage repair performance of the hydrogel is examined by implantation into a full‐thickness cartilage defect of a rabbit knee joint. The bilayer‐structure hydrogel promotes regeneration of osteochondral tissue, thus providing a new option for repair of osteochondral defects.

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Biodegradable Polymeric Nanoparticles as Templates for Biomimetic Mineralization of Calcium Phosphate

Cited by 15 publications

References 46 publications

Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery

Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery

Functional Hybrid Materials with Polymer Nanoparticles as Templates

Mussel‐Inspired Tough Hydrogel with In Situ Nanohydroxyapatite Mineralization for Osteochondral Defect Repair

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