Biodegradable Polymeric Nanoparticles for Brain-Targeted Drug Delivery

Kempe, Kristian; Nicolazzo, Joseph A.

doi:10.1007/978-1-0716-0838-8_1

Cited by 6 publications

(8 citation statements)

References 141 publications

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“…In the case of EDV, the drug regimen requires an infusion for 14 days, and kidney impairment is a common side effect in adults with ischemic stroke adult cases being treated with 6 mg/kg EDV. In order to solve this problem, smart and targeted drug delivery was utilized, using a ligand that would deliver the cargo to the targeted tissue, which would increase concentration of the drug in intended site of action and enhance the therapeutic outcome [ 28 ]. TGI is one of the validated methods to investigate stroke-like behavior and biochemical response of rodents to pharmaceutical compounds [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…TGI is one of the validated methods to investigate stroke-like behavior and biochemical response of rodents to pharmaceutical compounds [15]. Several free radical scavengers and natural antioxidants have been proven to be effective in neurodegenerative and neural damaging diseases [28][29][30]. GSH, a peptide composed of amino acids (cysteine, glycine, and glutamic acid), was utilized as a ligand for brain drug delivery which itself could slightly ameliorate oxidative stress in brain tissue.…”

Section: Discussionmentioning

confidence: 99%

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Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Mozafari

Rashidzadeh

Bijani

et al. 2023

Oxidative Medicine and Cellular Longevity

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Ischemic stroke is the most common among various stroke types and the second leading cause of death, worldwide. Edaravone (EDV) is one of the cardinal antioxidants that is capable of scavenging reactive oxygen species, especially hydroxyl molecules, and has been already used for ischemic stroke treatment. However, poor water solubility, low stability, and bioavailability in aqueous media are major EDV drawbacks. Thus, to overcome the aforementioned drawbacks, nanogel was exploited as a drug carrier of EDV. Furthermore, decorating the nanogel surface with glutathione as targeting ligands would potentiate the therapeutic efficacy. Nanovehicle characterization was assessed with various analytical techniques. Size (199 nm, hydrodynamic diameter) and zeta potential (-25 mV) of optimum formulation were assessed. The outcome demonstrated a diameter of around 100 nm, sphere shape, and homogenous morphology. Encapsulation efficiency and drug loading were determined to be 99.9% and 37.5%, respectively. In vitro drug release profile depicted a sustained release process. EDV and glutathione presence in one vehicle simultaneously made the possibility of antioxidant effects on the brain in specific doses, which resulted in elevated spatial memory and learning along with cognitive function in Wistar rats. In addition, significantly lower MDA and PCO and higher levels of neural GSH and antioxidant levels were observed, while histopathological improvement was approved. The developed nanogel can be a suited vehicle for drug delivery of EDV to the brain and improve ischemia-induced oxidative stress cell damage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Mozafari

Rashidzadeh

Bijani

et al. 2023

Oxidative Medicine and Cellular Longevity

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“…Nanoparticles of biodegradable polymers are unique systems for the delivery of various drugs into the human body [ 80 , 81 ]. The small size and easy possibility of functionalization of nanoparticles allow them to be used as a universal system for the delivery of various drugs [ 82 , 83 ].…”

Section: Main Applications Of Biodegradable Polymeric Nanoparticlesmentioning

confidence: 99%

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

et al. 2022

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Nanotechnology plays an important role in biological research, especially in the development of delivery systems with lower toxicity and greater efficiency. These include not only metallic nanoparticles, but also biopolymeric nanoparticles. Biopolymeric nanoparticles (BPNs) are mainly developed for their provision of several advantages, such as biocompatibility, biodegradability, and minimal toxicity, in addition to the general advantages of nanoparticles. Therefore, given that biopolymers are biodegradable, natural, and environmentally friendly, they have attracted great attention due to their multiple applications in biomedicine, such as drug delivery, antibacterial activity, etc. This review on biopolymeric nanoparticles highlights their various synthesis methods, such as the ionic gelation method, nanoprecipitation method, and microemulsion method. In addition, the review also covers the applications of biodegradable polymeric nanoparticles in different areas—especially in the pharmaceutical, biomedical, and agricultural domains. In conclusion, the present review highlights recent advances in the synthesis and applications of biopolymeric nanoparticles and presents both fundamental and applied aspects that can be used for further development in the field of biopolymeric nanoparticles.

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“…In addition, being coated in micelles or polyethylene glycol allows efficient targeting and transportation of the nanoparticles 44 , 45 . These nanoparticles are stable, an advantage that allows for detailed control of the carrier properties such as size and charge 46 . Preclinical studies have investigated lipid-based nanoparticles in combination with various agents, but with limited efficacy in brain cancer.…”

Section: Nanoparticle Drug Carriers To Cross the Bbbmentioning

confidence: 99%

Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy

Upton¹,

Ung²,

George³

et al. 2022

Theranostics

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Despite significant advances in research, the prognosis for both primary and secondary brain cancers remains poor. The blood-brain barrier (BBB) is a complex and unique semi-permeable membrane that serves as a protective structure to maintain homeostasis within the brain. However, it presents a significant challenge for the delivery of therapeutics into the brain and tumor. Some brain tumors are known to compromise BBB integrity, producing a highly heterogeneous vasculature known as the blood-tumor-barrier (BTB). Identifying strategies to bypass these obstacles to improve the penetrability of anticancer therapeutics has been the focus of research in this area. In this review, we discuss the strategies that have been investigated to evade or alter the cellular and molecular barriers of both the BBB and the BTB and detail the methods currently under preclinical or clinical investigation, including molecular, biological, and physical processes to overcome the BBB or BTB. Increased understanding of the BBB and BTB and the current methods of overcoming these barriers will enable the development of new and more effective treatment strategies for brain tumors.

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Biodegradable Polymeric Nanoparticles for Brain-Targeted Drug Delivery

Cited by 6 publications

References 141 publications

Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy

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