Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Gagliardi, Agnese; Giuliano, Elena; Venkateswararao, Eeda; Fresta, Massimo; Bulotta, Stefania; Awasthi, Vibhudutta; Cosco, Donato

doi:10.3389/fphar.2021.601626

Cited by 359 publications

(194 citation statements)

References 297 publications

(374 reference statements)

Supporting

Mentioning

159

Contrasting

Unclassified

Order By: Relevance

“…Also, the release of the therapeutic can be modified [ 75 ]. Gagliardi et al recently discussed the role of surfactants for the construction of polymeric NPs [ 25 ].…”

Section: Mechanism Of Action Of Polymeric Npsmentioning

confidence: 99%

“…Nevertheless, their clinical application is limited by their low solubility and toxicity [ 24 ]. Amongst the many materials used in nanomedicine, with promising properties as therapeutic carriers, the following one stands out: biodegradable and biocompatible polymers [ 25 , 26 ]. Polymeric NPs are ideal candidates for drug delivery, given the versatility of the raw materials used for their production.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment

Niza

Ocaña

Castro‐Osma

et al. 2021

Cancers

View full text Add to dashboard Cite

Many therapeutic agents have failed in their clinical development, due to the toxic effects associated with non-transformed tissues. In this context, nanotechnology has been exploited to overcome such limitations, and also improve navigation across biological barriers. Amongst the many materials used in nanomedicine, with promising properties as therapeutic carriers, the following one stands out: biodegradable and biocompatible polymers. Polymeric nanoparticles are ideal candidates for drug delivery, given the versatility of raw materials and their feasibility in large-scale production. Furthermore, polymeric nanoparticles show great potential for easy surface modifications to optimize pharmacokinetics, including the half-life in circulation and targeted tissue delivery. Herein, we provide an overview of the current applications of polymeric nanoparticles as platforms in the development of novel nanomedicines for cancer treatment. In particular, we will focus on the raw materials that are widely used for polymeric nanoparticle generation, current methods for formulation, mechanism of action, and clinical investigations.

show abstract

“…Also, the release of the therapeutic can be modified [ 75 ]. Gagliardi et al recently discussed the role of surfactants for the construction of polymeric NPs [ 25 ].…”

Section: Mechanism Of Action Of Polymeric Npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment

Niza

Ocaña

Castro‐Osma

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…PLGA-poly (D, L-lactide-co-glycolide) are the copolymers of glycolic and lactic acid (Essa et al, 2020). They are biodegradable and biocompatible NPs with target-specific delivery potentials inside cells or organs (Soppimath et al, 2001;Gagliardi et al, 2021). Modification of these NP's surfaces can offer stimuli-sensitive responses or target specific features-which may modulate their biodistribution and sitespecific target and concomitant uptake pathways in bacteria.…”

Section: Polymericmentioning

confidence: 99%

Nanoantibiotics: Functions and Properties at the Nanoscale to Combat Antibiotic Resistance

et al. 2021

View full text Add to dashboard Cite

One primary mechanism for bacteria developing resistance is frequent exposure to antibiotics. Nanoantibiotics (nAbts) is one of the strategies being explored to counteract the surge of antibiotic resistant bacteria. nAbts are antibiotic molecules encapsulated with engineered nanoparticles (NPs) or artificially synthesized pure antibiotics with a size range of ≤100 nm in at least one dimension. NPs may restore drug efficacy because of their nanoscale functionalities. As carriers and delivery agents, nAbts can reach target sites inside a bacterium by crossing the cell membrane, interfering with cellular components, and damaging metabolic machinery. Nanoscale systems deliver antibiotics at enormous particle number concentrations. The unique size-, shape-, and composition-related properties of nAbts pose multiple simultaneous assaults on bacteria. Resistance of bacteria toward diverse nanoscale conjugates is considerably slower because NPs generate non-biological adverse effects. NPs physically break down bacteria and interfere with critical molecules used in bacterial processes. Genetic mutations from abiotic assault exerted by nAbts are less probable. This paper discusses how to exploit the fundamental physical and chemical properties of NPs to restore the efficacy of conventional antibiotics. We first described the concept of nAbts and explained their importance. We then summarized the critical physicochemical properties of nAbts that can be utilized in manufacturing and designing various nAbts types. nAbts epitomize a potential Trojan horse strategy to circumvent antibiotic resistance mechanisms. The availability of diverse types and multiple targets of nAbts is increasing due to advances in nanotechnology. Studying nanoscale functions and properties may provide an understanding in preventing future outbreaks caused by antibiotic resistance and in developing successful nAbts.

show abstract

“…Biodegradable polysaccharides or biopolymer-based nanomaterials disintegrate during their intended function in physiological settings [51]. These polymers degrade in situ to generate the natural by-products such as water, carbon dioxide, and small organic molecules [52]. The backbone of these polysaccharides include functional groups of ester, amide, and ether that undergo enzymatic degradation in physiological environment [53].…”

Section: Physicochemical Factorsmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

View full text Add to dashboard Cite

The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

show abstract

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Cited by 359 publications

References 297 publications

Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment

Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment

Nanoantibiotics: Functions and Properties at the Nanoscale to Combat Antibiotic Resistance

Current-status and applications of polysaccharides in drug delivery systems

Contact Info

Product

Resources

About