Biodegradable Polymers for Focal Delivery Systems

Khan, Wahid; Challa, Venu Gopala Swami; Langer, Robert; Domb, Abraham J.

doi:10.1007/978-1-4614-9434-8_1

Cited by 9 publications

(2 citation statements)

References 139 publications

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“…They now have a successful record of accomplishment of ß50 years with applications branching off in diverse fields. A few successful applications include (6,68,(166)(167)(168)(169)(170)(171) surgical sutures, wound dressing, tissue regeneration, enzyme immobilization, controlled drug delivery and gene delivery, tissue engineering scaffold, cryopreservation, nanotechnology, medical implants and devices, prosthetics, augmentation, cosmetics, sanitation products, coatings, adhesives, and many more.…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Biodegradable Polymers: Medical Applications

Kunduru

Basu

Domb

2016

Encyclopedia of Polymer Science and Technology

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Biodegradable polymers are the “green materials” of the future. They break down into smaller chemical fragments and are finally eliminated from the body. Biodegradable polymers have been used for more than 50 years with diverse applications such as surgical sutures, wound dressings, tissue regeneration, enzyme immobilization, controlled drug delivery and gene delivery, tissue engineering scaffold, cryopreservation, nanotechnology, medical implants and devices, prosthetics, augmentation, cosmetics, sanitation products, coatings, adhesives, and many more. This article reviews synthetic (esters, amides, ethers, urethanes) and natural (polysaccharides and proteins) biodegradable polymers, highlighting their biomedical applications.

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Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Biodegradable Polymers: Medical Applications

Kunduru

Basu

Domb

2016

Encyclopedia of Polymer Science and Technology

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“…PLGA is approved by the US Food and Drug Administration (FDA) for clinical use and forms biodegradable metabolites (lactic and glycolic acid) when hydrolyzed at tricarboxylic acid (TCA) cycle in the biological system [4,10,11]. Multifunctional nanoparticles carrying more than one active ingredient at the same time may promote the drug synergism.…”

Section: Introductionmentioning

confidence: 99%

Enhanced antibacterial and antiparasitic activity of multifunctional polymeric nanoparticles

et al. 2020

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Due to the resistance to drugs, studies involving the combination and controlled release of different agents are gradually increasing. In this study, two different active ingredients, known to have antibacterial and antiparasitic activities, were encapsulated into single polymeric nanoparticles. After co-encapsulation their antibacterial and antileishmanial activity was enhanced approximately 5 and 250 times, respectively. Antibacterial and antileishmanial activities of caffeic acid phenethyl ester and juglone loaded, multifunctional nanoformulations (CJ4-CJ6-CJ8) were also evaluated for the first time in the literature comparatively with their combined free formulations. The antibacterial activity of the multifunctional nanoformulation (CJ8) were found to have a much higher activity (MIC values 6.25 and 12.5 μg ml −1 for S. aureus and E. coli, respectively) than all other formulations. Similar efficacy for CJ8 was obtained in the antiparasitic study against the Leishmania promastigotes and the IC 50 was reduced to 0.1263 μg ml −1 . The high activity of multifunctional nanoparticles is not only due to the synergistic effect of the active molecules but also by the encapsulation into polymeric nanoparticles. Therefore, it has been shown in the literature for the first time that the biological activity of molecules whose activity is increased by the synergistic effect can be improved with nanosystems.

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