Biodegradable Zwitterionic Cream Gel for Effective Prevention of Postoperative Adhesion

Abstract

Postoperative peritoneal adhesions are frequent complications for almost any type of abdominal and pelvic surgery. This leads to numerous medical problems and a huge financial burden to the patients. Current anti‐adhesion strategies focus mostly on physical barriers including films and hydrogels. However, they can only alleviate or reduce adhesions to a certain level and their applying processes are far from ideal. This work reported the development of a biodegradable zwitterionic cream gel presenting a series of characters for an ideal anti‐adhesion material, including unique injectable yet malleable and self‐supporting properties, which enables an instant topical application, no curing, waiting, or suturing, no hemostasis requirement, protein/cell resistance, and biodegradability. The cream gel shows a major advancement in anti‐adhesion efficacy by completely and reliably preventing a primary and more severe recurrent adhesion in rat models.

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

“…Zwitterionic hydrogel showed both much faster recovery rate and better hair growth ( Figure 21 a). For inside wound or potential postoperative adhesion, Zhang et al [ 171 ] prepared pCBAA cream-gel with a biodegradable BAC crosslinker to further improve resistant peritoneal adhesion ( Figure 21 b).…”

“…On days 7 and 14 post-surgery, adhesions were observed in the untreated control and intercede film groups, while no adhesion was observed in rats treated with cream-gel. Reproduced with permission from [ 171 ]. Copyright 2020 Wiley-VCH GmbH.…”

Facile preparation of a thermosensitive and antibiofouling physically crosslinked hydrogel/powder for wound healing

“…anti-adhesion, 36,37 antibacterial wound dressing, 38 etc. Chitosanbased hydrogels also have been widely used in the biomedical field due to their excellent biocompatibility, biodegradability, and good ability to kill bacteria.…”

An Injectable Asymmetric‐Adhesive Hydrogel as a GATA6+ Cavity Macrophage Trap to Prevent the Formation of Postoperative Adhesions after Minimally Invasive Surgery

“…Injectable zwitterionic hydrogels have been developed to prevent adhesions; however, the controllability of the gelation process in situ is a challenge that must be overcome [ 13 ] (Figure 1a; Table S1, Supporting Information). Furthermore, it has been recently reported that the uncontrolled recruitment of GATA6 + cavity macrophages leads to collagen deposition and postsurgical adhesion formation.…”