Biodentine and MTA modulate immunoinflammatory response favoring bone formation in sealing of furcation perforations in rat molars

Abstract

Biodentine and MTA exhibit potential as repair material in the treatment of furcation perforations.

Analysis of the Activity and Expression of Cyclooxygenases COX1 and COX2 in THP-1 Monocytes and Macrophages Cultured with BiodentineTM Silicate Cement

“…Biodentine TM (Septodont, Saint Maur des Fsses, France) is an example of a material based on hydrated calcium silicate. It shows odontotropic properties, that is, it stimulates the formation of reactive and reparative dentin and helps maintain proper sensitivity of the dental pulp [6][7][8][9]. The efficacy of the biological treatment of the pulp is higher in the younger patients as compared to the older patients [8].…”

“…The efficacy of the biological treatment of the pulp is higher in the younger patients as compared to the older patients [8]. This material is also used for sealing root perforation [9,10]. The teeth with perforations treated with Biodentine TM show regression of the inflammatory process and reduction in the bone resorption over time [1].…”

“…The teeth with perforations treated with Biodentine TM show regression of the inflammatory process and reduction in the bone resorption over time [1]. Moreover, it may also stimulate the expression of cell differentiation factors (including the osterix) and promote osteoblast differentiation and, consequently, bone neoformation [9,11]. Furthermore, it promotes fibroblast and osteoblast differentiation, stimulating the formation of collagen bundles of periodontal ligament and bone matrix of the alveolar process, respectively, favoring periodontal tissue repair [9,11].…”

“…Moreover, it may also stimulate the expression of cell differentiation factors (including the osterix) and promote osteoblast differentiation and, consequently, bone neoformation [9,11]. Furthermore, it promotes fibroblast and osteoblast differentiation, stimulating the formation of collagen bundles of periodontal ligament and bone matrix of the alveolar process, respectively, favoring periodontal tissue repair [9,11]. In vivo studies have reported that Biodentine TM exhibits low cytotoxicity in cultures of osteoblasts [12,13].…”

“…Under physiological conditions, macrophages are present in the pulp in a dormant state. Only during the development of the inflammatory process, do they show mobility and move to the site of inflammation [3][4][5]9].…”