Bioengineering, characterization, and biological activities of C@CuO@Cu nanocomposite based-mediated the Vicia faba seeds aqueous extract

Al-Hakkani, Mostafa F.; Hassan, Sedky H.A.; Saddik, Mohammed S.; El‐Mokhtar, Mohamed A.; Al-Shelkamy, Samah A.

doi:10.1016/j.jmrt.2021.07.076

Cited by 33 publications

(39 citation statements)

References 99 publications

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“…Al-Hakkani et al . 7 , 52 reported that the suspended particles had good stability if their charged surface passed the critical value ± 25 mV. The high negativity of the charged surface may be attributed to the polyphenolic constituents that act as stabilizing/capping agents.…”

Section: Results and Dissectionmentioning

confidence: 98%

Environmentally azithromycin pharmaceutical wastewater management and synergetic biocompatible approaches of loaded azithromycin@hematite nanoparticles

Al-Hakkani

Gouda

Hassan

et al. 2022

Sci Rep

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Pharmaceutical wastewater contamination via azithromycin antibiotic and the continuous emergence of some strains of bacteria, cancer, and the Covid-19 virus. Azithromycin wastewater treatment using the biosynthesized Hematite nanoparticles (α-HNPs) and the biocompatible activities of the resulted nanosystem were reported. Biofabrication of α-HNPs using Echinaceapurpurea liquid extract as a previously reported approach was implemented. An evaluation of the adsorption technique via the biofabricated α-HNPs for the removal of the Azr drug contaminant from the pharmaceutical wastewater was conducted. Adsorption isotherm, kinetics, and thermodynamic parameters of the Azr on the α-HNPs surface have been investigated as a batch mode of equilibrium experiments. Antibacterial, anticancer, and antiviral activities were conducted as Azr@α-HNPs. The optimum conditions for the adsorption study were conducted as solution pH = 10, 150 mg dose of α-HNPs, and Azr concentration 400 mg/L at 293 K. The most fitted isothermal model was described according to the Langmuir model at adsorption capacity 114.05 mg/g in a pseudo-second-order kinetic mechanistic at R2 0.9999. Thermodynamic study manifested that the adsorption behavior is a spontaneous endothermic chemisorption process. Subsequently, studying the biocompatible applications of the Azr@α-HNPs. Azr@α-HNPs antibacterial activity revealed a synergistic effect in the case of Gram-positive more than Gram-negative bacteria. IC50 of Azr@α-HNPs cytotoxicity against MCF7, HepG2, and HCT116 cell lines was investigated and it was found to be 78.1, 81.7, and 93.4 µg/mL respectively. As the first investigation of the antiviral use of Azr@α-HNPs against SARS-CoV-2, it was achieved a safety therapeutic index equal to 25.4 revealing a promising antiviral activity. An admirable impact of the use of the biosynthesized α-HNPs and its removal nanosystem product Azr@α-HNPs was manifested and it may be used soon as a platform of the drug delivery nanosystem for the biomedical applications.

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Section: Results and Dissectionmentioning

confidence: 98%

Environmentally azithromycin pharmaceutical wastewater management and synergetic biocompatible approaches of loaded azithromycin@hematite nanoparticles

Al-Hakkani

Gouda

Hassan

et al. 2022

Sci Rep

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“…Also, the other XRD parameters could be estimated as the strain of the lattice (ℇ), placing distance (d), dislocation density (δ) and stacking fault (α), crystallinity (%), and crystallinity index (CI) as manifested in the supplementary material file; Eqs. ( 1 – 7 ) 3 , 36 , 37 . FT-IR analysis was recorded on a Thermo Fisher [Nicolet iS10 FT-IR spectrometer] in a wavenumber range of 4000–400 cm −1 using an ATR module.…”

Section: Methodsmentioning

confidence: 99%

“…Water containing organic pollutants such as industrial pharmaceutical waste and chemicals generated by textile industries has an impact on the biological cycle, specifically the photosynthesis process in plants, which has a direct impact on marine species and an indirect impact on human life 2 . Furthermore, polluted water has a significant influence on the life of birds, animals, and humans who are impacted by contaminated flowing water 3 .…”

Section: Introductionmentioning

confidence: 99%

“…These issues can be overcome by immobilizing the solid support PCD , which has an outstanding capacity to isolate Nano-sized materials and is cost-effective 32 . There is considerable interest in the wastewater treatment approach development that inevitably involves photocatalysts based on semiconductor nanomaterials especially transition metal oxides like BiVO 4 , WO 3 , ZrO 2 , TiO 2 , MnO 2 , Fe 2 O 3 , CuO, Cu/TiO 2 , ZnO, ZnO/Sb 2 MoO 6 , and C@Cu 2 O@Cu nanocomposite 1 , 3 , 33 – 39 .…”

Section: Introductionmentioning

confidence: 99%

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Cefotaxime removal enhancement via bio-nanophotocatalyst α-Fe2O3 using photocatalytic degradation technique and its echo-biomedical applications

Al-Hakkani

Gouda

Hassan

et al. 2022

Sci Rep

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The present paper evaluates the photocatalytic degradation (PCD) performance of the biofabricated hematite nanoparticles (α-HNPs) for the degradation approach of the Cefotaxime (Cfm). The optimum pH of the solution to achieve the best PCD was found to be 10.5. The kinetics study for the PCD of the Cfm via α-HNPs has been investigated and the reaction was found to be fellow pseudo-first-order at R2 = 0.992. The mass loading impact of α-HNPs was investigated and estimated for the maximum degradation of Cfm 0.4 mg/mL. UV–Vis confirmed that α-HNPs had a direct transition bandgap at 3.78 eV at a maximum absorption wavelength of 362 nm with suspension stability for 7 days. The probable mechanism of the Cfm PCD via α-HNPs and the degradation pathway was conducted. The validation of the suspension stability of the α-HNPs (−68.6 ± 11.8 mV) was determined using the zeta potential investigation test. XRD investigation was conducted after Cfm PCD showing an average crystallite size of 27.0 nm. XRD, TEM, SEM, EDX, and FT-IR analyses have been conducted for the α-HNPs before and after Cfm PCD confirming the high efficiency for the reusability of the current biocatalyst α-HNPs for further use. TEM results of the particle sizes of α-HNPs were found at 19.2 ± 4.4 and 20.6 ± 7.4 nm respectively before and after Cfm PCD. The efficiency of the Cfm PCD was found to be 99.1% after 6 h. High potent as an antibacterial agent of α-HNPs was investigated either α-HNPs alone or after its PCD activity against Cfm. The antibacterial activity revealed high sensitivity, especially toward Gram-positive species indicating its promising ability against pathogenic issues. Interestingly, Cfm@α-HNPs showed superior anti-proliferative activity as tested by MTT assay and were able to induce apoptosis in MCF7 and HepG2 cell lines using the flow cytometry technique at 20.7% and 17% respectively. Also, The IC50 of hydrogen peroxide scavenging was estimated and it was manifested that 635.8 and 665.6 μg/mL of α-HNPs before and after the PCD process of Cfm respectively.

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“…Various AZM characteristic bands could be identified in the spectra acquired straight from the solid standard, as shown in Figure 1A. The main bands identified were (i) bands associated with the axial stretching and bending of C-H of the methyl groups, which were found in the ranges of 2966-2985 cm −1 and 1367-1374 cm −1 , respectively [57,58]; (ii) the sharp and powerful band at 1710-1722 cm −1 , which could be attributed to the axial stretching of the lactone's C=O group; and (iii) other notable bands in the spectra, including those found in the 1130-1225 cm −1 region, which emerged due to absorption related to C-O axial stretching [59].…”

Section: Ft-ir Analysismentioning

confidence: 99%

Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing

et al. 2022

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Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications that usually include colonization by pathogenic bacteria, leading to fever and sepsis, which further impairs and complicates the healing process. So, there is an urgent need to develop a novel pharmaceutical material that promotes the healing of infected wounds. The present work aimed to prepare and evaluate the efficacy of novel azithromycin-loaded zinc oxide nanoparticles (AZM-ZnONPs) in the treatment of infected wounds. The Box–Behnken design and response surface methodology were used to evaluate loading efficiency and release characteristics of the prepared NPs. The minimum inhibitory concentration (MIC) of the formulations was determined against Staphylococcus aureus and Escherichia coli. Moreover, the anti-bacterial and wound-healing activities of the AZM-loaded ZnONPs impregnated into hydroxyl propyl methylcellulose (HPMC) gel were evaluated in an excisional wound model in rats. The prepared ZnONPs were loaded with AZM by adsorption. The prepared ZnONPs were fully characterized by XRD, EDAX, SEM, TEM, and FT-IR analysis. Particle size distribution for the prepared ZnO and AZM-ZnONPs were determined and found to be 34 and 39 nm, respectively. The mechanism by which AZM adsorbed on the surface of ZnONPs was the best fit by the Freundlich model with a maximum load capacity of 160.4 mg/g. Anti-microbial studies showed that AZM-ZnONPs were more effective than other controls. Using an experimental infection model in rats, AZM-ZnONPs impregnated into HPMC gel enhanced bacterial clearance and epidermal regeneration, and stimulated tissue formation. In conclusion, AZM -loaded ZnONPs are a promising platform for effective and rapid healing of infected wounds.

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Bioengineering, characterization, and biological activities of C@CuO@Cu nanocomposite based-mediated the Vicia faba seeds aqueous extract

Cited by 33 publications

References 99 publications

Environmentally azithromycin pharmaceutical wastewater management and synergetic biocompatible approaches of loaded azithromycin@hematite nanoparticles

Environmentally azithromycin pharmaceutical wastewater management and synergetic biocompatible approaches of loaded azithromycin@hematite nanoparticles

Cefotaxime removal enhancement via bio-nanophotocatalyst α-Fe2O3 using photocatalytic degradation technique and its echo-biomedical applications

Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing

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