Biofabricating the Vascular Tree in Engineered Bone Tissue

Silva, Leanne de; Bernal, Paulina Núñez; Rosenberg, Antoine J.W.P.; Malda, Jos; Levato, Riccardo; Gawlitta, Debby

doi:10.2139/ssrn.4097607

Cited by 2 publications

(2 citation statements)

References 150 publications

(203 reference statements)

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“…The formation of blood vessels is orchestrated mainly by two different mechanisms: vasculogenesis and angiogenesis, the first occurs in the early stages of embryonic development, from hemangioblasts that will form the primitive vascular plexus and the heart (Dumitrescu et al, 2021), while angiogenesis is the formation of blood vessels from islets of blood by endothelial progenitor cells with the ability to differentiate into vascular cells (Chambers et al, 2021). However, although angiogenesis is the formation of postnatal blood vessels, it has a primary function of vascular remodeling to achieve vascular fusion, that is, the larger blood vessels are reduced and segmented to form primary and secondary vascular plexuses allowing their interconnection and circulation of the blood and its products (Yin et al, 2021;Nitzsche et al, 2022;Ribatti, 2022), inducing the formation of a hierarchical network known as the "Vascular Tree", which includes capillaries, venules, arterioles, veins and arteries (de Silva et al, 2022;Ghanem, 2022).…”

Section: Importance Of Vascular Network In Tissue Regenerationmentioning

confidence: 99%

Biofunctionalization of hydrogel-based scaffolds for vascular tissue regeneration

López-Gutierrez¹,

Ramos‐Payán²,

Ayala-Ham³

et al. 2023

Front. Mater.

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Congenital and acquired tissular losses due to disease or trauma are a major world health problem. Regenerative therapy aims to fix damaged tissues by directing the natural capacity of a host organism to use biofunctionalized artificial tissue scaffolds. These three-dimensional (3D) scaffolds can be customized with cells and/or bioactive molecules to induce cellular homing and angiogenesis, essential to ensure successful tissue regeneration. Hydrogels (HGs) scaffolds are networks of hydrophilic homopolymers, copolymers, and/or macromers with chemical and biological activities that enhance their cell colonization. The use of HGs in regenerative medicine has shown to be advantageous since HGs can be prepared under clinical-grade conditions and tailored to the specific needs of the replaced tissue. They can be made to emulate native extracellular matrices (ECMs) including physical, mechanical, and chemical cues and resilience properties. These customized HGs can reproduce the natural hygroscopic capacity of the original tissue which improves cellular anchoring, nutrition, and waste disposal. They can enable host molecular and cellular modification conducive to a natural cellular microenvironment, modifying the properties of the scaffold, and improving chemotaxis, cell adhesion, migration, proliferation, differentiation, and angiogenesis; HGs can be created and biofunctionalized with linked growth factors and synthetic peptides tailored to positively influence scaffold colonization and functional biocompatibility. This review aims to collect the most relevant information regarding biofunctionalization of HGs used for vascular tissue regeneration, their biological effects, and their clinical implications. While most biofunctionalized HGs are still under investigation, some of them have been studied in vitro, ex vivo, and in vivo with promising results. In this regard, in vivo studies have shown that biofunctionalized scaffolds with peptides such as chitosan hydrogel with LL-37 promotes angiogenesis and healing of pressure ulcers. Also, the GHK tripeptide is widely used in trials focused on guided tissue remodeling.

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Section: Importance Of Vascular Network In Tissue Regenerationmentioning

confidence: 99%

Biofunctionalization of hydrogel-based scaffolds for vascular tissue regeneration

López-Gutierrez¹,

Ramos‐Payán²,

Ayala-Ham³

et al. 2023

Front. Mater.

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“…Bone tissue is a vascular-rich tissue, and the oxygen and various nutrients needed by bone tissue cells come from the vascular system, which provides a transport channel for metabolites [1][2] . A clinically rich vascular system ensures the nutritional supply of the transplanted bone mass and improves its survival rate [3] .…”

Section: Introductionmentioning

confidence: 99%

Research progress on the angiogenic-osteogenic coupling signaling molecules of bone tissue engineering

2023

FMSR

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Angiogenesis and osteogenesis are integral to the process of bone growth, development, and repair and reconstruction. The close spatial and temporal association between osteogenesis and angiogenesis is known as "angiogenesis-osteogenesis coupling". Vascular invasion is a prerequisite for bone formation, and their mutual coupling is a key factor in bone formation. Vessels not only provide nutrients, transport oxygen, growth factors and metabolic wastes to bone tissue, but also regulate the various stages of angiogenesis and bone formation through vascular endothelial growth factor and angiopoietin. With the extensive research on tissue engineering in recent years, the role of signaling molecules related to angiogenesis-osteogenesis coupling in bone tissue engineering has been broadened. In this paper, we intend to review the relevant research results in order to provide ideas for tissue engineering bone vascularization.

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Biofabricating the Vascular Tree in Engineered Bone Tissue

Cited by 2 publications

References 150 publications

Biofunctionalization of hydrogel-based scaffolds for vascular tissue regeneration

Biofunctionalization of hydrogel-based scaffolds for vascular tissue regeneration

Research progress on the angiogenic-osteogenic coupling signaling molecules of bone tissue engineering

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