Biofilm application in the microbial biochemicals production process

Jiang, Yujia; Zhang, Xiaoyu; Gao, Hao; Mou, Lu; Wu, Mengdi; Zhang, Wenming; Xin, Fengxue; Jiang, Min

doi:10.1016/j.biotechadv.2021.107724

Cited by 42 publications

(28 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 B) [ 23 , 50 ]. For instance, QS regulates biofilm synthesis, which can be utilized to improve lignocellulose conversion [ 52 , 53 ]. On one hand, the concentration of cell-associated hydrolytic enzymes at the biofilm-substrate interface can be increased to improve saccharification [ 53 , 54 ].…”

Section: Microbial Interaction Modes and Molecular Mechanismsmentioning

confidence: 99%

“…For instance, QS regulates biofilm synthesis, which can be utilized to improve lignocellulose conversion [ 52 , 53 ]. On one hand, the concentration of cell-associated hydrolytic enzymes at the biofilm-substrate interface can be increased to improve saccharification [ 53 , 54 ]. On the other hand, symbiotic biofilms, which consists of aerobic fungi (e.g., T. reesei ) and anaerobic bacteria (e.g., L. pentosus ), is an ideal strategy for simultaneous (hemi) cellulose hydrolysis and products (e.g., lactic acid) generation [ 55 , 56 ].…”

Section: Microbial Interaction Modes and Molecular Mechanismsmentioning

confidence: 99%

“…Various microbial spatial and temporal segregations exist in nature. For example, aerobic and anaerobic microbial populations are separated by oxic/anoxic niches [ 22 ], whereas biofilms provide structured microenvironments [ 53 , 56 , 79 , 80 ]. Such spatial organization of microbes generates locally heterogeneous subpopulations, which can acquire different resources, and further enhance local interactions.…”

Section: Synthetic Ecology Provides An Opportunity To “Bottom-up” Design Synthetic Microbial Consortia For Efficient Lignocellulose Biocomentioning

confidence: 99%

“…Biofilm-based separation shed light on enhancement of lignocellulosic bioconversion. For a cellulose degrader, biofilms can not only strengthen physical contact between microbial cells and cellulose substrate, but also enhance concentration of cellulases at the biofilm-substrate interface to promote hydrolysis rates, e.g., 70% higher cellulase activity by Aspergillus niger biofilm, compared to suspended A. niger culture [ 53 , 81 ]. For a product producer, biofilm also increased biochemical production, due to the increment of surface area for mass transfer and cell resistance against adverse environment [ 53 , 56 ].…”

Section: Synthetic Ecology Provides An Opportunity To “Bottom-up” Design Synthetic Microbial Consortia For Efficient Lignocellulose Biocomentioning

confidence: 99%

See 3 more Smart Citations

Bottom-up synthetic ecology study of microbial consortia to enhance lignocellulose bioconversion

Lin

2022

Biotechnol Biofuels

View full text Add to dashboard Cite

Lignocellulose is the most abundant organic carbon polymer on the earth. Its decomposition and conversion greatly impact the global carbon cycle. Furthermore, it provides feedstock for sustainable fuel and other value-added products. However, it continues to be underutilized, due to its highly recalcitrant and heterogeneric structure. Microorganisms, which have evolved versatile pathways to convert lignocellulose, undoubtedly are at the heart of lignocellulose conversion. Numerous studies that have reported successful metabolic engineering of individual strains to improve biological lignin valorization. Meanwhile, the bottleneck of single strain modification is becoming increasingly urgent in the conversion of complex substrates. Alternatively, increased attention has been paid to microbial consortia, as they show advantages over pure cultures, e.g., high efficiency and robustness. Here, we first review recent developments in microbial communities for lignocellulose bioconversion. Furthermore, the emerging area of synthetic ecology, which is an integration of synthetic biology, ecology, and computational biology, provides an opportunity for the bottom-up construction of microbial consortia. Then, we review different modes of microbial interaction and their molecular mechanisms, and discuss considerations of how to employ these interactions to construct synthetic consortia via synthetic ecology, as well as highlight emerging trends in engineering microbial communities for lignocellulose bioconversion.

show abstract

Section: Microbial Interaction Modes and Molecular Mechanismsmentioning

confidence: 99%

Section: Microbial Interaction Modes and Molecular Mechanismsmentioning

confidence: 99%

Section: Synthetic Ecology Provides An Opportunity To “Bottom-up” Design Synthetic Microbial Consortia For Efficient Lignocellulose Biocomentioning

confidence: 99%

Section: Synthetic Ecology Provides An Opportunity To “Bottom-up” Design Synthetic Microbial Consortia For Efficient Lignocellulose Biocomentioning

confidence: 99%

See 2 more Smart Citations

Bottom-up synthetic ecology study of microbial consortia to enhance lignocellulose bioconversion

Lin

2022

Biotechnol Biofuels

View full text Add to dashboard Cite

show abstract

“…Meanwhile, some scholars have also studied how to develop and take advantage of microbial biofilms. Due to the strong viability and high density, biofilm cells can well accumulate the secreted enzymes and fermentation products such as acid and alcohol, thus be used to continuously and efficiently produce biochemicals [ 20 ]. Besides, factories also utilize biofilm reactors to treat sewage.…”

Section: Microbial Biofilms In Various Applicationsmentioning

confidence: 99%

Regulatory network controls microbial biofilm development, with Candida albicans as a representative: from adhesion to dispersal

Huang

et al. 2022

Bioengineered

View full text Add to dashboard Cite

Microorganisms mainly exist in the form of biofilm in nature. Biofilm can contaminate food and drinking water system, as well as cause chronic wound infections, thereby posing a potential threat to public health safety. In the last two decades, researchers have made efforts to investigate the genetic contributors control different stages of biofilm development (adherence, initiation, maturation, and dispersal). As an opportunistic pathogen, C. albicans causes severe superficial or systemic infections with high morbidity and mortality under conditions of immune dysfunction. It has been reported that 80% of C. albicans infections are directly or indirectly associated with biofilm formation on host or abiotic surfaces including indwelling medical devices, resulting in high morbidity and mortality. Significantly, the outcome of C. albicans biofilm development includes enhanced invasion, exacerbated inflammatory responses and intrinsic resistance to antimicrobial chemotherapy. Thus, this review aimed at providing a comprehensive overview of the regulatory network controls microbial biofilm development, with C. albicans as a representative, served as reference for therapeutic targets.

show abstract

Climate Change, Its Effects on Soil Health, and Role of Bioinoculants in Mitigating Climate Change

Velmourougane

Prasanna

2023

Bioinoculants: Biological Option for Mitigating Global Climate Change

View full text Add to dashboard Cite

Biofilm application in the microbial biochemicals production process

Cited by 42 publications

References 74 publications

Bottom-up synthetic ecology study of microbial consortia to enhance lignocellulose bioconversion

Bottom-up synthetic ecology study of microbial consortia to enhance lignocellulose bioconversion

Regulatory network controls microbial biofilm development, with Candida albicans as a representative: from adhesion to dispersal

Climate Change, Its Effects on Soil Health, and Role of Bioinoculants in Mitigating Climate Change

Contact Info

Product

Resources

About