Biofilms and Apical Periodontitis: Study of Prevalence and Association with Clinical and Histopathologic Findings

Ricucci, Domenico; Siqueira, José F.

doi:10.1016/j.joen.2010.04.007

Cited by 613 publications

(563 citation statements)

References 36 publications

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“…14 While the immune response pattern associated with a clear disease outcome seems to vary significantly, the common point among progressive lesions (in both periodontitis and periapical lesions) seems to be the presence of recognized pathogens. [40][41][42][43] Therefore, the data presented herein demonstrates a disproportionate large effect of the presence/absence of red complex bacteria with the disease status and the periodontitis subrogate variable PD. Even though the T-allele carriers were enriched in the diseased group, and the TT and CT genotypes were overrepresented in the CP patients group (indicating an association of the SNP with the disease status); the environmental microbiological covariate obscures this association in the logistic regression model.…”

Section: Discussionmentioning

confidence: 64%

TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic bacterial infection

et al. 2015

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Section: Discussionmentioning

confidence: 64%

TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic bacterial infection

et al. 2015

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“…According to Ricucci and Siqueira Jr, 25 most cases of periradicular infections are caused by intraradicular bacterial biofilms. They found biofilm structures in 80% and 74% cases of primary and secondary infections, respectively.…”

Section: Discussionmentioning

confidence: 99%

Ex vivo evaluation of three instrumentation techniques on E. faecalis biofilm within oval shaped root canals

et al. 2015

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Ex vivo evaluation of three instrumentation techniques on E. faecalis biofilm within oval shaped root canals Abstract: The objective of the present study was to assess the effectiveness of reciprocating instrumentation in disinfecting oval-shaped root canals infected with Enterococcus faecalis. Forty-five human lower premolars were infected with a culture of E. faecalis (ATCC 29212) for 28 days. Five other teeth that were neither contaminated nor instrumented were used as controls. The 45 specimens were divided into three experimental groups (n = 15) based on the root canal preparation technique used: manual (K-type, Dentsply Maillefer, Ballaigues, Switzerland); rotary (MTwo, VDW GmbH, Munich, Germany); and reciprocating (Reciproc R50, VDW GmbH, Munich, Germany) instruments. During chemomechanical preparation, 21 mL of 2.5% NaOCl was used as the irrigating solution. Microbiological sampling was performed before (S1) and immediately after (S2) the chemomechanical preparation using sterilized paper points. Specimens were then cleaved, and 0.02 g of dentine chips was collected from the root thirds to verify the presence of microorganisms in dentinal tubules. All three preparation techniques reduced the number of microorganisms in the root canal lumen and dentine chips from the root thirds, but no significant differences were observed between the three groups (p > 0.05). Reciprocating instrumentation with Reciproc R50 was effective in reducing the number of microorganisms within the root canal system. Although this technique involves the use of only one file to perform the root canal therapy, it is as effective as conventional rotary instrumentation in reducing the E. faecalis biofilm from the root canal system. However, further clinical investigations are warranted in order to ratify these results.

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“…These include but are not limited to the absence of an apical lesion, use of dental dams during treatment and core placement, use of surgical operating microscopes, periodontal condition, structural integrity/restorability of the tooth, biofilms, and effective post-endodontic restoration. 4,14,15,16,17,18,19,20,21,22 The endodontic literature is replete with research focused on these local factors, yet few articles have been published that focus on the effect of provider training on outcomes. Alley et al 23 found that endodontic treatment provided by endodontic specialists was more than 10% more successful than treatment provided by general dentists.…”

mentioning

confidence: 99%

Outcomes of Primary Endodontic Therapy Provided by Endodontic Specialists Compared with Other Providers

Burry

Stover

Eichmiller

et al. 2016

Journal of Endodontics

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Introduction: The objective of this study was to compare the outcomes of initial nonsurgical root canal therapy for different tooth types provided by both endodontists and other providers. Methods: By using an insurance company database, 487,476 initial nonsurgical root canal therapy procedures were followed from the time of treatment to the presence of an untoward event indicated by Current Dental Terminology codes for retreatment, apical surgery, or extraction. Population demographics were computed for provider type and tooth location. KaplanMeier survival estimates were calculated for 1, 5, and 10 years. Hazard ratios for provider type and tooth location were calculated by using the Cox proportional hazards model. Results:The survival of all teeth collectively was 98% at 1 year, 92% at 5 years, and 86% at 10 years. Significant differences in survival on the basis of provider type were noted for molars at 5 years and for all tooth types at 10 years. The greatest difference discovered was 5% higher survival rate at 10 years for molars treated by endodontists. A hazard ratio of 1.394 was found when comparing other providers' success with that of endodontists within this 10-year molar group. Conclusions: These findings show that survival rates of endodontically treated teeth are high at 10 years after treatment regardless of provider type. Molars treated by endodontists after 10 years have significantly higher survival rates than molars treated by non-endodontists.

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Biofilms and Apical Periodontitis: Study of Prevalence and Association with Clinical and Histopathologic Findings

Cited by 613 publications

References 36 publications

TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic bacterial infection

TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic bacterial infection

Ex vivo evaluation of three instrumentation techniques on E. faecalis biofilm within oval shaped root canals

Outcomes of Primary Endodontic Therapy Provided by Endodontic Specialists Compared with Other Providers

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