2024
DOI: 10.1146/annurev-micro-112123-100908
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Biogenesis and Functionality of Sortase-Assembled Pili in Gram-Positive Bacteria

Chungyu Chang,
Nicholas A. Ramirez,
Aadil H. Bhat
et al.

Abstract: A unique class of multimeric proteins made of covalently linked subunits known as pili, or fimbriae, are assembled and displayed on the gram-positive bacterial cell surface by a conserved transpeptidase enzyme named pilus-specific sortase. Sortase-assembled pili are produced by a wide range of gram-positive commensal and pathogenic bacteria inhabiting diverse niches such as the human oral cavity, gut, urogenital tract, and skin. These surface appendages serve many functions, such as molecular adhesins, immunom… Show more

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