Biogenic selenium nanoparticles alleviate intestinal epithelial barrier injury by regulating mitochondria–lysosome crosstalk

Dou, Xina; Qiao, Lei; Song, Xiaofan; Chang, Jiajing; Pi, Shanyao; Zhang, Xinyi; Zeng, Xiaonan; Zhu, Lixu; Xu, Chunlan

doi:10.1039/d2fo03992c

Cited by 6 publications

(1 citation statement)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, upregulation of miR-182 in I/R mice leading to a significant reduction in autophagosomes has also found morphological evidence observed by TEM[ 44 ]. Studies have found that selenium nanoparticles can effectively alleviate intestinal epithelial barrier damage by inhibiting autophagy mediated by the TBC1D15/Rab7 signaling pathway[ 45 ]. In contrast to the above studies, activation of the AMPK/ SIRT1-autophagy pathway alleviated intestinal I/R injury[ 46 , 47 ].…”

Section: Autophagy and Gi Diseasesmentioning

confidence: 99%

Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases

Chang,

Li,

Liu

et al. 2024

World J Gastroenterol

View full text Add to dashboard Cite

Autophagy is a cellular catabolic process characterized by the formation of double-membrane autophagosomes. Transmission electron microscopy is the most rigorous method to clearly visualize autophagic engulfment and degradation. A large number of studies have shown that autophagy is closely related to the digestion, secretion, and regeneration of gastrointestinal (GI) cells. However, the role of autophagy in GI diseases remains controversial. This article focuses on the morphological and biochemical characteristics of autophagy in GI diseases, in order to provide new ideas for their diagnosis and treatment.

show abstract

Section: Autophagy and Gi Diseasesmentioning

confidence: 99%

Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases

Chang,

Li,

Liu

et al. 2024

World J Gastroenterol

View full text Add to dashboard Cite

show abstract

Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

Zhang,

Yang,

Guo

et al. 2024

J of Applied Toxicology

View full text Add to dashboard Cite

Mitophagy is a selective cellular process critical for the removal of damaged mitochondria. It is essential in regulating mitochondrial number, ensuring mitochondrial functionality, and maintaining cellular equilibrium, ultimately influencing cell destiny. Numerous pathologies, such as neurodegenerative diseases, cardiovascular disorders, cancers, and various other conditions, are associated with mitochondrial dysfunctions. Thus, a detailed exploration of the regulatory mechanisms of mitophagy is pivotal for enhancing our understanding and for the discovery of novel preventive and therapeutic options for these diseases. Nanomaterials have become integral in biomedicine and various other sectors, offering advanced solutions for medical uses including biological imaging, drug delivery, and disease diagnostics and therapy. Mitophagy is vital in managing the cellular effects elicited by nanomaterials. This review provides a comprehensive analysis of the molecular mechanisms underpinning mitophagy, underscoring its significant influence on the biological responses of cells to nanomaterials. Nanoparticles can initiate mitophagy via various pathways, among which the PINK1‐Parkin pathway is critical for cellular defense against nanomaterial‐induced damage by promoting mitophagy. The role of mitophagy in biological effects was induced by nanomaterials, which are associated with alterations in Ca2+ levels, the production of reactive oxygen species, endoplasmic reticulum stress, and lysosomal damage.

show abstract

Selenium Nanoparticles as Neuroprotective Agents: Insights into Molecular Mechanisms for Parkinson’s Disease Treatment

Umapathy,

Pan,

Issac

et al. 2024

Mol Neurobiol

View full text Add to dashboard Cite

Biogenic selenium nanoparticles alleviate intestinal epithelial barrier injury by regulating mitochondria–lysosome crosstalk

Abstract: SeNPs can regulate mitochondrial and lysosomal crosstalk through the TBC1D15/Fis1/Rab7-mediated signaling pathway and maintain cell homeostasis, and further effectively alleviate intestinal epithelial barrier dysfunction in IPEC-J2 cells exposed to LPS.

Cited by 6 publications

References 48 publications

Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases

Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases

Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

Selenium Nanoparticles as Neuroprotective Agents: Insights into Molecular Mechanisms for Parkinson’s Disease Treatment

Contact Info

Product

Resources

About