Biogenic silver nanoparticles: In vitro and in vivo antitumor activity in bladder cancer

Ferreira, Luiz Alberto Bandeira; Garcia-Fóssa, Fernanda; Radaic, Allan; Fávaro, Wagner José; Jesus, Marcelo Bispo de

doi:10.1016/j.ejpb.2020.04.012

Cited by 30 publications

(25 citation statements)

References 44 publications

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“…Their results demonstrated that, in BC cells, AgNP caused DNA double-strand breaks and lead to apoptosis, which reduces migration and cell proliferation. So, these results confirmed that AgNPs could be an effective tool for the treatment of BC [ 144 ].…”

Section: Applications Of Nanomaterials In Treatment Of Bcsupporting

confidence: 62%

“…Today, AgNP is used to treat a variety of cancer cells, mainly due to its antineoplastic properties, which enable it to simulate cancer cell death in the same way traditional chemotherapy does. The functions of Ag NPs anti-tumor activity probably is correlated with the releasing of metallic silver (Ag 0 ) and silver cations (Ag + ), which can both cause oxidative stress, mitochondrial and DNA damage, phospholipid bilayer membrane destruction, and genotoxicity, outcoming in cell death by necrosis or apoptosis [ 144 ].…”

Section: Applications Of Nanomaterials In Treatment Of Bcmentioning

confidence: 99%

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Nanotechnology in Bladder Cancer: Diagnosis and Treatment

Barani

Hosseinikhah

Rahdar

et al. 2021

Cancers

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Bladder cancer (BC) is the second most common cancer of the urinary tract in men and the fourth most common cancer in women, and its incidence rises with age. There are many conventional methods for diagnosis and treatment of BC. There are some current biomarkers and clinical tests for the diagnosis and treatment of BC. For example, radiotherapy combined with chemotherapy and surgical, but residual tumor cells mostly cause tumor recurrence. In addition, chemotherapy after transurethral resection causes high side effects, and lack of selectivity, and low sensitivity in sensing. Therefore, it is essential to improve new procedures for the diagnosis and treatment of BC. Nanotechnology has recently sparked an interest in a variety of areas, including medicine, chemistry, physics, and biology. Nanoparticles (NP) have been used in tumor therapies as appropriate tools for enhancing drug delivery efficacy and enabling therapeutic performance. It is noteworthy, nanomaterial could be reduced the limitation of conventional cancer diagnosis and treatments. Since, the major disadvantages of therapeutic drugs are their insolubility in an aqueous solvent, for instance, paclitaxel (PTX) is one of the important therapeutic agents utilized to treating BC, due to its ability to prevent cancer cell growth. However, its major problem is the poor solubility, which has confirmed to be a challenge when improving stable formulations for BC treatment. In order to reduce this challenge, anti-cancer drugs can be loaded into NPs that can improve water solubility. In our review, we state several nanosystem, which can effective and useful for the diagnosis, treatment of BC. We investigate the function of metal NPs, polymeric NPs, liposomes, and exosomes accompanied therapeutic agents for BC Therapy, and then focused on the potential of nanotechnology to improve conventional approaches in sensing.

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Section: Applications Of Nanomaterials In Treatment Of Bcsupporting

confidence: 62%

Section: Applications Of Nanomaterials In Treatment Of Bcmentioning

confidence: 99%

Nanotechnology in Bladder Cancer: Diagnosis and Treatment

Barani

Hosseinikhah

Rahdar

et al. 2021

Cancers

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“…4,5 AgNPs are known to inhibit cancer cell proliferation in a variety of cell types. Especially, these nanoparticles have been found to be inhibitory to the viability of carcinoma cells of the bladder, 6 breast, 7 lung, 8 and larynx. 9 Interestingly, silver-based nanoparticles have been shown to be particularly effective against breast neoplasms 10,11 and hepatic cancer.…”

Section: Introductionmentioning

confidence: 99%

Proteomic and metabolomic profiling combined with in vitro studies reveal the antiproliferative mechanism of silver nanoparticles in MDA-MB-231 breast carcinoma cells

2022

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“…Cell cycle arrest was induced by the spherical AgNPs. Ferreira et al [305] conducted in vitro and in vivo studies with biogenic AgNPs produced by Fusarium sp. In vitro treatment with IC50 decreased clonogenic survival, whereas treatment with IC25 had a negligible effect on clonogenic survival.…”

Section: Agnps For Anticancer Therapymentioning

confidence: 99%

Synthesis, Characterization and Biomedical Application of Silver Nanoparticles

et al. 2022

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Silver nanoparticles (AgNPs) have been employed in various fields of biotechnology due to their proven properties as an antibacterial, antiviral and antifungal agent. AgNPs are generally synthesized through chemical, physical and biological approaches involving a myriad of methods. As each approach confers unique advantages and challenges, a trends analysis of literature for the AgNPs synthesis using different types of synthesis were also reviewed through a bibliometric approach. A sum of 10,278 publications were analyzed on the annual numbers of publication relating to AgNPs and biological, chemical or physical synthesis from 2010 to 2020 using Microsoft Excel applied to the Scopus publication database. Furthermore, another bibliometric clustering and mapping software were used to study the occurrences of author keywords on the biomedical applications of biosynthesized AgNPs and a total collection of 224 documents were found, sourced from articles, reviews, book chapters, conference papers and reviews. AgNPs provides an excellent, dependable, and effective solution for seven major concerns: as antibacterial, antiviral, anticancer, bone healing, bone cement, dental applications and wound healing. In recent years, AgNPs have been employed in biomedical sector due to their antibacterial, antiviral and anticancer properties. This review discussed on the types of synthesis, how AgNPs are characterized and their applications in biomedical field.

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Biogenic silver nanoparticles: In vitro and in vivo antitumor activity in bladder cancer

Cited by 30 publications

References 44 publications

Nanotechnology in Bladder Cancer: Diagnosis and Treatment

Nanotechnology in Bladder Cancer: Diagnosis and Treatment

Proteomic and metabolomic profiling combined with in vitro studies reveal the antiproliferative mechanism of silver nanoparticles in MDA-MB-231 breast carcinoma cells

Synthesis, Characterization and Biomedical Application of Silver Nanoparticles

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