Biogenic Silver Nanoparticles: Synthesis and Application as Antibacterial and Antifungal Agents

Rozhin, Artem; Batasheva, Svetlana; Kruychkova, Marina; Cherednichenko, Yuliya; Rozhina, Elvira; Fakhrullin, Rawil

doi:10.3390/mi12121480

Cited by 72 publications

(49 citation statements)

References 125 publications

(154 reference statements)

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“…This is probably related to the rapid release of antibiotics with early peak values in the blood and a rapid decline of blood levels. There are many in vitro studies showing the bactericidal effect of silver [29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Use of a Silver-Impregnated Vascular Graft: Single-Center Experience

et al. 2022

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Introduction: Vascular graft infection is a life threatening situation with significant morbidity and mortality. Bacterial graft infection can lead to false aneurysms, bleeding and sepsis. There are a lot of risky situations where grafts can become infected. It is therefore highly desirable to have a vascular graft that is resistant to infection. In this retrospective clinical study, a silver-impregnated vascular graft was evaluated in various indications. Methods: Our study included a total of 71 patients who received a silver-impregnated vascular graft during the period from 2013 to 2018. Patients had an aortoiliac localization of vascular graft in 61 cases (86%), and a peripheral localization on the lower limbs in 10 cases (14%). Indications for the use of these special vascular grafts were trophic lesions or gangrene in the lower limbs in 24 cases (34%), suspicious mycotic abdominal aortic aneurysm (mAAA) in 4 cases (5.5%), salmonela aortitis or aneurysms in 4 cases (5.5%), infection of the previous vascular graft in 11 cases (15.5%), other infections in 12 cases (17%), AAA rupture in 10 cases (14%) and other reasons (pre-transplant condition, multiple trauma, graft-enteric fistula) in 6 cases (8.5%). Thirty-day mortality, morbidity, the need for reintervention and amputation, primary and secondary graft patency, and finally the presence of a proven vascular graft infection were evaluated. Results: The 30-day mortality was 19.7%, and morbidity was 42.2%. The primary patency of the vascular graft was 91.5%. Reoperation was necessary in 10 cases (14%) and amputation was necessary in 10 cases (14%). The median length of hospital stay was 13 days and the mean follow-up period was 48 ± 9 months. During the follow-up period, six patients (8.5%) died from reasons unrelated to surgery or without any relation to the vascular graft. Secondary patency after one year was 88%. Infection of the silver graft was observed in three patients (4.2%). Conclusions: Based on our results, the silver graft is a very suitable alternative for solving infectious, or potentially infectious, situations in vascular surgery. In particular, in urgent or acute cases, a silver graft is often the only option.

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Section: Discussionmentioning

confidence: 99%

Use of a Silver-Impregnated Vascular Graft: Single-Center Experience

et al. 2022

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“…The silver nanoparticles were biocompatible and non-toxic to mammalian cells, and their antifungal activity was dependent on the applied concentration. It is noteworthy that Ag NPs exhibited stronger antifungal activity than antifungal drugs [ 23 ].…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research

Szewczyk

Roszczenko

Czarnomysy

et al. 2022

IJMS

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Several authorities have implied that nanotechnology has a significant future in the development of advanced cancer therapies. Nanotechnology makes it possible to simultaneously administer drug combinations and engage the immune system to fight cancer. Nanoparticles can locate metastases in different organs and deliver medications to them. Using them allows for the effective reduction of tumors with minimal toxicity to healthy tissue. Transition-metal nanoparticles, through Fenton-type or Haber–Weiss-type reactions, generate reactive oxygen species. Through oxidative stress, the particles induce cell death via different pathways. The main limitation of the particles is their toxicity. Certain factors can control toxicity, such as route of administration, size, aggregation state, surface functionalization, or oxidation state. In this review, we attempt to discuss the effects and toxicity of transition-metal nanoparticles.

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“…Plants have biomolecules that are sources of antimicrobial and antifungal compounds that can serve as both reducing and stabilizing agents during the production of silver and gold nanoparticles [ 1 , 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Eugenia uniflora L. Silver and Gold Nanoparticle Synthesis, Characterization, and Evaluation of the Photoreduction Process in Antimicrobial Activities

2022

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Eugenia uniflora linnaeus, known as Brazilian cherry, is widely distributed in Brazil, Argentina, Uruguay, and Paraguay. E. uniflora L. extracts contain phenolic compounds, such as flavonoids, tannins, triterpenes, and sesquiterpenes. The antimicrobial action of essential oils has been attributed to their compositions of bioactive compounds, such as sesquiterpenes. In this paper, the fruit extract of E. uniflora was used to synthesize silver and gold nanoparticles. The nanoparticles were characterized by UV–Vis, transmission electron microscopy, elemental analysis, FTIR, and Zeta potential measurement. The silver and gold nanoparticles prepared with fruit extracts presented sizes of ~32 nm and 11 nm (diameter), respectively, and Zeta potentials of −22 mV and −14 mV. The antimicrobial tests were performed with Gram-negative and Gram-positive bacteria and Candida albicans. The growth inhibition of EuAgNPs prepared with and without photoreduction showed the important functional groups in the antimicrobial activity.

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Biogenic Silver Nanoparticles: Synthesis and Application as Antibacterial and Antifungal Agents

Cited by 72 publications

References 125 publications

Use of a Silver-Impregnated Vascular Graft: Single-Center Experience

Use of a Silver-Impregnated Vascular Graft: Single-Center Experience

An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research

Eugenia uniflora L. Silver and Gold Nanoparticle Synthesis, Characterization, and Evaluation of the Photoreduction Process in Antimicrobial Activities

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